Characterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis.


Journal

Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359

Informations de publication

Date de publication:
2024
Historique:
received: 16 04 2024
accepted: 12 09 2024
medline: 15 10 2024
pubmed: 15 10 2024
entrez: 15 10 2024
Statut: epublish

Résumé

Hepatic tuberculosis (HTB) is rare extrapulmonary tuberculosis that is clinically similar to liver malignancy, making it difficult for correct diagnoses. Pathology is the gold standard for tuberculosis diagnosis. However, there are few reports on the pathological features of HTB. A total of 32 HTB cases were considered and the differences in pathological features and drug resistance were analyzed and compared with those for pulmonary tuberculosis (PTB). Enhanced CT scans showed ring-shaped delayed enhancement during the arterial, venous, and delayed phases. Most HTB cases were single lesions, with the highest incidence in the right lobe, and the average lesion volume was smaller than that of PTB. The frequency of granuloma in pathological changes, the overall share of the lesion area in the HTB group, and the number of foxp3

Identifiants

pubmed: 39403208
doi: 10.3389/fcimb.2024.1418225
pmc: PMC11472707
doi:

Substances chimiques

Forkhead Transcription Factors 0
FOXP3 protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1418225

Informations de copyright

Copyright © 2024 Niu, Wu, Pan, Ge, Chen and Liu.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Qiang Niu (Q)

Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Runrui Wu (R)

Department of Pathology, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China.

Ke Pan (K)

Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Xinlan Ge (X)

Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

Wen Chen (W)

Department of Pathology, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China.

Rong Liu (R)

Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.

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Classifications MeSH