Assessing the stability of daptomycin in icodextrin-based peritoneal dialysis solution.
Chromatography
daptomycin
icodextrin-based PD
quantitative analysis
stability
Journal
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
ISSN: 1718-4304
Titre abrégé: Perit Dial Int
Pays: United States
ID NLM: 8904033
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
medline:
15
10
2024
pubmed:
15
10
2024
entrez:
15
10
2024
Statut:
aheadofprint
Résumé
The stability of antimicrobials in peritonitis during peritoneal dialysis (PD) solutions is a critical factor influencing treatment success. This study investigated the stability of daptomycin (DAP) when combined with icodextrin-based PD solution, by measuring DAP concentrations and observing any structural changes. A dose of DAP (350 mg) was dissolved in 7 mL of saline in a clean bench. The solution was then injected into the large compartment (1,260 mL) of NICOPELIQ DAP maintained 90% of the initial concentration in NICOPELIC The findings from this stability study are expected to enhance the effectiveness of outpatient management and preparation for treating peritonitis using DAP.
Sections du résumé
BACKGROUND
BACKGROUND
The stability of antimicrobials in peritonitis during peritoneal dialysis (PD) solutions is a critical factor influencing treatment success. This study investigated the stability of daptomycin (DAP) when combined with icodextrin-based PD solution, by measuring DAP concentrations and observing any structural changes.
METHODS
METHODS
A dose of DAP (350 mg) was dissolved in 7 mL of saline in a clean bench. The solution was then injected into the large compartment (1,260 mL) of NICOPELIQ
RESULTS
RESULTS
DAP maintained 90% of the initial concentration in NICOPELIC
CONCLUSIONS
CONCLUSIONS
The findings from this stability study are expected to enhance the effectiveness of outpatient management and preparation for treating peritonitis using DAP.
Identifiants
pubmed: 39403764
doi: 10.1177/08968608241283526
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8968608241283526Déclaration de conflit d'intérêts
Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.