Cerebral palsy characteristics in term-born children with and without detectable perinatal risk factors: A cross-sectional study.

Journal

Developmental medicine and child neurology

ISSN: 1469-8749

Titre abrégé: Dev Med Child Neurol

Pays: England

ID NLM: 0006761

Informations de publication

Date de publication:
15 Oct 2024

Historique:

revised: 30 08 2024

received: 26 06 2024

accepted: 13 09 2024

medline: 15 10 2024

pubmed: 15 10 2024

entrez: 15 10 2024

Statut: aheadofprint

Résumé

To compare, in term-born children with cerebral palsy (CP), the characteristics of those who exhibit detectable risk factors for CP at birth with those who do not. This was a cross-sectional study of term-born children using the Canadian Cerebral Palsy Registry comparing those with and without perinatal risk factors and/or neonatal symptoms for pregnancy, birth and neonatal characteristics, magnetic resonance imaging (MRI) findings, CP subtype, and impairment severity. Risk factors were quantified with a CP risk calculator. Multivariable and multinomial regressions were expressed as odds ratios (OR) and relative risk ratios. Of 1333 term-born children, 781 (58.6%) had complete variables for the CP risk calculator, of whom 195 (25%) had 'undetectable' newborn infant CP risk, and they did not have greater postneonatal brain injury. Focal injury on MRI was more common (OR 2.0, 95% confidence interval [CI] 1.3-3.1) than in the 'detectable' group. The 'undetectable' group had more unilateral CP (OR 1.8, 95% CI 1.3-2.6), less severe motor impairment (OR 0.76, 95% CI 0.67-0.86), and were more verbal (OR 2.3, 95% CI 1.5-3.6). In the Canadian CP Registry, one-quarter of term-born children lacked neonatal encephalopathy, seizures, or perinatal risk factors. They were more likely to have unilateral CP, focal MRI findings, and communicate with words than children with risk factors or neonatal symptoms.

Identifiants

DOI: 10.1111/dmcn.16111 PMID: 39404141

pubmed: 39404141

doi: 10.1111/dmcn.16111

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Alberta Children's Hospital Research Institute

Investigateurs

John Andersen (J)

David Buckley (D)

Darcy Fehlings (D)

Lee Burkholder (L)

Adam Kirton (A)

Louise Koclas (L)

Nicole Pigeon (N)

Ram Mashal (R)

Jordan Sheriko (J)

Ellen Wood (E)

Michael Shevell (M)

Informations de copyright

Références

Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, et al. A report: the definition and classification of cerebral palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.

Shevell M. Cerebral palsy to cerebral palsy spectrum disorder: Time for a name change? Neurology. 2019 Jan 28;92(5):233–235.

Novak I, Hines M, Goldsmith S, Barclay R. Clinical Prognostic Messages From a Systematic Review on Cerebral Palsy. Pediatrics. 2012 Nov 1;130(5):e1285–312.

McIntyre S, Goldsmith S, Webb A, Ehlinger V, Hollung SJ, McConnell K, et al. Global prevalence of cerebral palsy: A systematic analysis. Dev Med Child Neurol. 2022;64(12):1494–506.

Hollung SJ, Vik T, Lydersen S, Bakken IJ, Andersen GL. Decreasing prevalence and severity of cerebral palsy in Norway among children born 1999 to 2010 concomitant with improvements in perinatal health. Eur J Paediatr Neuro. 2018;22(5):814–21.

Smithers‐Sheedy H, Waight E, Goldsmith S, Reid S, Gibson C, Watson L, et al. Declining trends in birth prevalence and severity of singletons with cerebral palsy of prenatal or perinatal origin in Australia: A population‐based observational study. Dev Medicine Child Neurology. 2022;

Waight E. Post‐neonatally acquired cerebral palsy aetiology: The need for classification and collaboration. Dev Med Child Neurol. 2023;66(2):146–7.

Pudig L, Delobel‐Ayoub M, Horridge K, Gergeli AT, Sellier E, Ehlinger V, et al. Classification of events contributing to postneonatal cerebral palsy: Development, reliability, and recommendations for use. Dev Med Child Neurol. 2024;66(2):250–7.

Germany L, Ehlinger V, Klapouszczak D, Delobel M, Hollódy K, Sellier E, et al. Trends in prevalence and characteristics of post‐neonatal cerebral palsy cases: A European registry‐based study. Res Dev Disabil. 2013;34(5):1669–77.

Cans C, McManus V, Crowley M, Guillem P, Platt M, Johnson A, et al. Cerebral palsy of post‐neonatal origin: characteristics and risk factors. Paediatr Périnat Epidemiology. 2004;18(3):214–20.

Novak I, Morgan C, Adde L, Blackman J, Boyd RN, Brunstrom‐Hernandez J, et al. Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment. JAMA pediatrics. 2017 Sep 1;171(9):897–907.

Hendson L, Church PT, Banihani R. Follow‐up care of the extremely preterm infant after discharge from the neonatal intensive care unit. Paediatr Child Heal. 2022;27(6):359–64.

Morgan C, Fetters L, Adde L, Badawi N, Bancale A, Boyd RN, et al. Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy. JAMA Pediatr. 2021;175(8):846–58.

Monica T, Catherine M, Iona N. New Screening Tool for Term‐Born Infants Enables Update to the Clinical Practice Guideline for Early Diagnosis of Cerebral Palsy. Jama Pediatr. 2023;177(2):115–7.

McIntyre S, Badawi N, Brown C, Blair E. Population Case‐Control Study of Cerebral Palsy: Neonatal Predictors for Low‐Risk Term Singletons. Pediatrics. 2011;127(3):e667–73.

Rouabhi A, Husein N, Dewey D, Letourneau N, Daboval T, Oskoui M, et al. Development of a Bedside Tool to Predict the Diagnosis of Cerebral Palsy in Term‐Born Neonates. Jama Pediatr. 2023;177(2).

Garfinkle J, Wintermark P, Shevell MI, Oskoui M. Children born at 32 to 35 weeks with birth asphyxia and later cerebral palsy are different from those born after 35 weeks. J Perinatol. 2017;37(8):963–8.

Vitagliano M, Dunbar M, Holzinger SD, Letourneau N, Dewey D, Oskoui M, et al. Perinatal arterial ischemic stroke and periventricular venous infarction in infants with unilateral cerebral palsy. Dev Medicine Child Neurology. 2021;

Elm E von, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007;370(9596):1453–7.

Springer A, Holzinger SD, Andersen J, Buckley D, Fehlings D, Kirton A, et al. Profile of children with cerebral palsy spectrum disorder and a normal MRI study. Neurology. 2019;93(1):e88–96.

Badawi N, Felix JF, Kurinczuk JJ, Dixon G, Watson L, Keogh JM, et al. Cerebral palsy following term newborn encephalopathy: a population‐based study. Dev Med Child Neurol. 2005;47(5):293–8.

Morgan C, Fahey M, Roy B, Novak I. Diagnosing cerebral palsy in full‐term infants. J Paediatr Child H. 2018;54(10):1159–64.

Li Y, Wisnowski JL, Chalak L, Mathur AM, McKinstry RC, Licona G, et al. Mild hypoxic‐ischemic encephalopathy (HIE): timing and pattern of MRI brain injury. Pediatr Res. 2022;92(6):1731–6.

Wisnowski JL, Monsell SE, Bluml S, Goodman AM, Li Y, Comstock BA, et al. Brain Injury Outcomes after Adjuvant Erythropoietin Neuroprotection for Moderate or Severe Neonatal Hypoxic‐Ischemic Encephalopathy: A Report from the HEAL Trial. Dev Neurosci. 2023;1–12.

Parmentier CEJ, Steggerda SJ, Weeke LC, Rijken M, Vries LSD, Groenendaal F. Outcome of non‐cooled asphyxiated infants with under‐recognised or delayed‐onset encephalopathy. Archives Dis Child ‐ Fetal Neonatal Ed. 2021;fetalneonatal‐2020‐321331.

Fortin O, Husein N, Oskoui M, Shevell MI, Kirton A, Registry CCP, et al. Risk Factors and Outcomes for Cerebral Palsy With Hypoxic‐Ischemic Brain Injury Patterns Without Documented Neonatal Encephalopathy. Neurology. 2024;102(6):e208111.

Goldsmith S, McIntyre S, Scott H, Himmelmann K, Smithers‐Sheedy H, Andersen GL, et al. Congenital anomalies in children with postneonatally acquired cerebral palsy: an international data linkage study. Dev Med Child Neurol. 2021;63(4):421–8.

McMichael G, Bainbridge MN, Haan E, Corbett M, Gardner A, Thompson S, et al. Whole‐exome sequencing points to considerable genetic heterogeneity of cerebral palsy. Mol Psychiatry. 2015;20(2):176–82.

Oskoui M, Gazzellone MJ, Thiruvahindrapuram B, Zarrei M, Andersen J, Wei J, et al. Clinically relevant copy number variations detected in cerebral palsy. Nat Commun. 2015;6(1):7949.

Schaefer GB. Genetics Considerations in Cerebral Palsy. Semin Pediatr Neurol. 2008;15(1):21–6.

Srivastava S, Lewis SA, Cohen JS, Zhang B, Aravamuthan BR, Chopra M, et al. Molecular Diagnostic Yield of Exome Sequencing and Chromosomal Microarray in Cerebral Palsy. Jama Neurol. 2022;79(12).

Gonzalez‐Mantilla PJ, Hu Y, Myers SM, Finucane BM, Ledbetter DH, Martin CL, et al. Diagnostic Yield of Exome Sequencing in Cerebral Palsy and Implications for Genetic Testing Guidelines. JAMA Pediatr. 2023;177(5):472–8.

May HJ, Fasheun JA, Bain JM, Baugh EH, Bier LE, Revah‐Politi A, et al. Genetic testing in individuals with cerebral palsy. Dev Medicine Child Neurology. 2021;63(12):1448–55.

Fehlings DL, Zarrei M, Engchuan W, Sondheimer N, Thiruvahindrapuram B, MacDonald JR, et al. Comprehensive whole‐genome sequence analyses provide insights into the genomic architecture of cerebral palsy. Nat Genet. 2024;1–10.

Segel R, Ben‐Pazi H, Zeligson S, Fatal‐Valevski A, Aran A, Gross‐Tsur V, et al. Copy number variations in cryptogenic cerebral palsy. Neurology. 2015;84(16):1660–8.

Dunbar MJ, Mineyko A, Hill M, Hodge J, Floer A, Kirton A. Population Based Birth Prevalence of Disease‐Specific Perinatal Stroke. Pediatrics. 2020 Nov;146(5):e2020013201.

Dunbar MJ, Woodward K, Leijser LM, Kirton A. Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta‐analysis. Developmental medicine and child neurology [Internet]. 2020 Oct 22;162(3):173–12. Available from: https://onlinelibrary‐wiley‐com.ezproxy.library.ubc.ca/doi/pdfdirect/10.1111/dmcn.14713

Eisman S, Husein N, Fehlings D, Andersen J, Oskoui M, Shevell M, et al. Early Biomarkers in the Prediction of Later Functional Impairment in Term Children with Cerebral Palsy. Pediatr Neurol. 2023;140:59–64.

Yang M, Eide S, Tam EWY, Chau V, Chen SRW, Miller SP, et al. Worsening of cerebral palsy following neonatal encephalopathy: A meta‐analysis. Adv Neurol. 2023;2(4):1719.

Fehlings D, Majnemer A, Ogourtsova T. Early Detection and Intervention Toolkit for children with CP (EDIT‐CP) [Internet]. [cited 2024 Jan 30]. Available from: https://www.childhooddisability.ca/early‐detection‐of‐cp/

Hay K, Nelin M, Carey H, Chorna O, Mas MMCM, Maitre N, et al. Hammersmith Infant Neurological Examination Asymmetry Score Detects Hemiplegic Cerebral Palsy From Typical Development. Pediatric neurology. 2018 Jul 25;

Kapil N, Majmudar‐Sheth B, Johnson T. Hammersmith Infant Neurological Examination Subscores are Predictive of Cerebral Palsy. Pediatr Neurol. 2023;

Hornby B, Paleg GS, Williams SA, Hidalgo‐Robles Á, Livingstone RW, Wright PEM, et al. Identifying Opportunities for Early Detection of Cerebral Palsy. Children. 2024;11(5):515.

Boychuck Z, Andersen J, Bussières A, Fehlings D, Kirton A, Li P, et al. International expert recommendations of clinical features to prompt referral for diagnostic assessment of cerebral palsy. Developmental medicine and child neurology. 2020 Jan;62(1):89–96.

Smilga AS, Garfinkle J, Ng P, Andersen J, Buckley D, Fehlings D, et al. Neonatal Infection in Children With Cerebral Palsy: A Registry‐Based Cohort Study. Pediatr Neurol. 2018;80:77–83.