Normocalcemic primary hyperparathyroidism is not associated with cardiometabolic alterations.

Blood pressure Calcium Cardiometabolic Glucose Normocalcemic primary hyperparathyroidism Parathormone

Journal

Endocrine
ISSN: 1559-0100
Titre abrégé: Endocrine
Pays: United States
ID NLM: 9434444

Informations de publication

Date de publication:
15 Oct 2024
Historique:
received: 14 08 2024
accepted: 27 09 2024
medline: 15 10 2024
pubmed: 15 10 2024
entrez: 15 10 2024
Statut: aheadofprint

Résumé

Cardiometabolic disorders are non-classical complications of hypercalcemic primary hyperparathyroidism (HC-PHPT), but whether this risk connotes normocalcemic PHPT (NC-PHPT) remains to be elucidated. We investigated cardiometabolic alterations in both forms of PHPT, looking for their association with indices of disease activity. Patients with HC-PHPT (n = 17), NC-PHPT (n = 17), and controls (n = 34) matched for age, sex, and BMI were assessed for glucose, lipid, blood pressure alterations, and history of cardiovascular events to perform a case-control study at an ambulatory referral center for Bone Metabolism Diseases. NC-PHPT, in comparison to controls, showed similar glucose (mean ± SD, 88 ± 11 vs 95 ± 22 mg/dl), total cholesterol (199 ± 25 vs 207 ± 36 mg/dl), and systolic blood pressure levels (SBP, 132 ± 23 vs 132 ± 19 mmHg), together with a comparable frequency of glucose alterations (6% vs 9%), lipid disorders (41% vs 50%) and hypertension (53% vs 59%, p = NS for all comparisons). Conversely, all these abnormalities were more prevalent in HC-PHPT vs controls (p < 0.05). When compared to NC-PHPT, HC-PHPT showed higher glucose (113 ± 31 mg/dl), total cholesterol (238 ± 43 mg/dl), and SBP levels (147 ± 15 mmHg) as well as an increased frequency of glucose (41%) and lipid alterations (77%) and a higher number of cardiovascular events (18% vs 0%, p < 0.05 for all comparisons). Among indices of PHPT activity, calcium levels displayed a significant correlation with glucose (R = 0.46) and SBP values (R = 0.60, p < 0.05). NC-PHPT is not associated with cardiovascular alterations. The predominant pathogenetic role of hypercalcemia in the development of cardiometabolic disorders could account for the absence of such alterations in NC-PHPT.

Identifiants

pubmed: 39404961
doi: 10.1007/s12020-024-04063-0
pii: 10.1007/s12020-024-04063-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Marco Barale (M)

Division of Oncological Endocrinology; Department of Medical Sciences, University of Turin, Turin, Italy. marco.barale@unito.it.

Federica Maiorino (F)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Alessia Pusterla (A)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Federica Fraire (F)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Lorenzo Sauro (L)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Michela Presti (M)

Division of Oncological Endocrinology; Department of Medical Sciences, University of Turin, Turin, Italy.

Noemi Sagone (N)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Ezio Ghigo (E)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Emanuela Arvat (E)

Division of Oncological Endocrinology; Department of Medical Sciences, University of Turin, Turin, Italy.

Massimo Procopio (M)

Division of Endocrinology, Diabetes and Metabolism; Department of Medical Sciences, University of Turin, Turin, Italy.

Classifications MeSH