Light-driven synchronization of optogenetic clocks.

Optogenetics / methods Escherichia coli / genetics Light Biological Clocks / physiology Circadian Clocks / genetics Models, Theoretical
E. coli computational biology nonlinear dynamics optogenetics physics of living systems synthetic biology systems biology

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
15 Oct 2024
Historique:
medline: 15 10 2024
pubmed: 15 10 2024
entrez: 15 10 2024
Statut: epublish

Résumé

Synthetic genetic oscillators can serve as internal clocks within engineered cells to program periodic expression. However, cell-to-cell variability introduces a dispersion in the characteristics of these clocks that drives the population to complete desynchronization. Here, we introduce the optorepressilator, an optically controllable genetic clock that combines the repressilator, a three-node synthetic network in

Identifiants

DOI: 10.7554/eLife.97754 PMID: 39405096
pubmed: 39405096
doi: 10.7554/eLife.97754
pii: 97754
doi:
pii:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Research Council
ID : 834615
Pays : International
Organisme : Ministero dell'Università e della Ricerca
ID : R20R4X8ZEL

Informations de copyright

© 2024, Cannarsa et al.

Déclaration de conflit d'intérêts

MC, FL, NP, GF, RD No competing interests declared

Auteurs

Maria Cristina Cannarsa (MC)

Department of Physics, Sapienza University of Rome, Roma, Italy.
Department of Biology and Biotechnology Charles Darwin, Sapienza University of Rome, Rome, Italy.
ORCID: 0009-0009-4126-4022

Filippo Liguori (F)

Department of Physics, Sapienza University of Rome, Roma, Italy.
Center for Life Nano & Neuro Science, Fondazione Istituto Italiano di Tecnologia (IIT), Roma, Italy.
ORCID: 0000-0003-2859-6953

Nicola Pellicciotta (N)

Department of Physics, Sapienza University of Rome, Roma, Italy.
NANOTEC-CNR, Soft and Living Matter Laboratory, Institute of Nanotechnology, Rome, Italy.
ORCID: 0000-0002-7105-9566

Giacomo Frangipane (G)

Department of Physics, Sapienza University of Rome, Roma, Italy.
NANOTEC-CNR, Soft and Living Matter Laboratory, Institute of Nanotechnology, Rome, Italy.
ORCID: 0000-0002-1533-4754

Roberto Di Leonardo (R)

Department of Physics, Sapienza University of Rome, Roma, Italy.
NANOTEC-CNR, Soft and Living Matter Laboratory, Institute of Nanotechnology, Rome, Italy.
ORCID: 0000-0002-5020-0663

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Optogénétique › Light-driven synchronization of optogenetic clocks.
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › Light-driven synchronization of optogenetic clocks.
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Light-driven synchronization of optogenetic clocks.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Light-driven synchronization of optogenetic clocks.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Horloges biologiques › Horloges circadiennes › Light-driven synchronization of optogenetic clocks.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Light-driven synchronization of optogenetic clocks.