Akkermansia muciniphila: biology, microbial ecology, host interactions and therapeutic potential.


Journal

Nature reviews. Microbiology
ISSN: 1740-1534
Titre abrégé: Nat Rev Microbiol
Pays: England
ID NLM: 101190261

Informations de publication

Date de publication:
15 Oct 2024
Historique:
accepted: 02 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 15 10 2024
Statut: aheadofprint

Résumé

Akkermansia muciniphila is a gut bacterium that colonizes the gut mucosa, has a role in maintaining gut health and shows promise for potential therapeutic applications. The discovery of A. muciniphila as an important member of our gut microbiome, occupying an extraordinary niche in the human gut, has led to new hypotheses on gut health, beneficial microorganisms and host-microbiota interactions. This microorganism has established a unique position in human microbiome research, similar to its role in the gut ecosystem. Its unique traits in using mucin sugars and mechanisms of action that can modify host health have made A. muciniphila a subject of enormous attention from multiple research fields. A. muciniphila is becoming a model organism studied for its ability to modulate human health and gut microbiome structure, leading to commercial products, a genetic model and possible probiotic formulations. This Review provides an overview of A. muciniphila and Akkermansia genus phylogeny, ecophysiology and diversity. Furthermore, the Review discusses perspectives on ecology, strategies for harnessing beneficial effects of A. muciniphila for human mucosal metabolic and gut health, and its potential as a biomarker for diagnostics and prognostics.

Identifiants

pubmed: 39406893
doi: 10.1038/s41579-024-01106-1
pii: 10.1038/s41579-024-01106-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Athanasia Ioannou (A)

Laboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands.

Maryse D Berkhout (MD)

Laboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands.

Sharon Y Geerlings (SY)

Laboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands.

Clara Belzer (C)

Laboratory of Microbiology, Wageningen University and Research, Wageningen, The Netherlands. clara.belzer@wur.nl.

Classifications MeSH