Immunometabolic Rewiring: A Tale of Macronutrients and Macrophages.
Immunometabolism
Macronutrient intake
Resident tissue macrophages (RTMs)
Journal
Results and problems in cell differentiation
ISSN: 0080-1844
Titre abrégé: Results Probl Cell Differ
Pays: Germany
ID NLM: 0173555
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
15
10
2024
Statut:
ppublish
Résumé
Myeloid cells, including monocytes, macrophages, dendritic cells, and polymorphonuclear cells are key components of homeostasis maintenance and immune response. Among the myeloid lineage, macrophages stand out as highly versatile cells that safeguard tissue functions but also sense and respond to potentially harmful microenvironmental cues. Numerous studies have demonstrated that the nutritional status and macronutrient availability affect macrophage identity and function. However, the exact mechanistic links between macronutrient intake and cellular metabolic shifts are only beginning to be understood. In this chapter, we explore how dietary "macros"-carbohydrates, fats, and amino acids-impact the immunomodulatory activity of macrophages in healthy and inflamed tissues.
Identifiants
pubmed: 39406902
doi: 10.1007/978-3-031-65944-7_3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-118Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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