Appearance time of blood in the brain as a possible indicator of oxygen extraction fraction: a feasibility study.
15O-labelled tracer
Appearance time of blood
Cerebral blood flow
Oxygen extraction fraction
Positron emission tomography
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
16 Oct 2024
16 Oct 2024
Historique:
received:
15
03
2024
accepted:
04
10
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
15
10
2024
Statut:
epublish
Résumé
Imaging examination of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen is crucial for understanding the normal functioning and pathophysiology of the brain. A recently developed method estimates the appearance time of cerebral blood (ATB) pixel-wise from the imaging examination of CBF alone. In this study, we aimed to test the potential of ATB as an indicator of OEF. We retrospectively reviewed patients (n = 62) with suspected cerebrovascular disorders including steno-occlusive disease who underwent positron emission tomography (PET) with Our results indicate the potential of ATB as an indicator of OEF.
Sections du résumé
BACKGROUND
BACKGROUND
Imaging examination of cerebral blood flow (CBF), oxygen extraction fraction (OEF), and metabolic rate of oxygen is crucial for understanding the normal functioning and pathophysiology of the brain. A recently developed method estimates the appearance time of cerebral blood (ATB) pixel-wise from the imaging examination of CBF alone. In this study, we aimed to test the potential of ATB as an indicator of OEF.
RESULTS
RESULTS
We retrospectively reviewed patients (n = 62) with suspected cerebrovascular disorders including steno-occlusive disease who underwent positron emission tomography (PET) with
CONCLUSION
CONCLUSIONS
Our results indicate the potential of ATB as an indicator of OEF.
Identifiants
pubmed: 39406936
doi: 10.1186/s13550-024-01160-z
pii: 10.1186/s13550-024-01160-z
doi:
Types de publication
Journal Article
Langues
eng
Pagination
97Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K17201
Informations de copyright
© 2024. The Author(s).
Références
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