Synthesis, Anti-Cancer Activity, Cell Cycle Arrest, Apoptosis Induction, and Docking Study of Fused Benzo[


Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
04 Oct 2024
Historique:
received: 30 08 2024
revised: 16 09 2024
accepted: 26 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Breast cancer is the predominant form of cancer among women and ranks as the second most prevalent cancer globally, affecting both developed and less developed countries. Presently, accessible cancer treatment methods either employ recently created, secure, and efficient chemotherapeutic medications or directly target innovative pathways that cause apoptosis. One of the indirect strategies for treating this fatal illness has mostly depended on its essential role in cell cycle arrest and apoptosis induction, as well as the antagonistic interaction between the Bcl-2 and Mcl-1 proteins, in order to avert major health repercussions. We reported that newly synthesized fused chromenopyrimidines (

Identifiants

pubmed: 39407625
pii: molecules29194697
doi: 10.3390/molecules29194697
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Pyrimidines 0
Proto-Oncogene Proteins c-bcl-2 0
Myeloid Cell Leukemia Sequence 1 Protein 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Taif University, Saudi Arabia
ID : project number ( TU- DSPP- 2024- 54)

Auteurs

Zainab M Khoder (ZM)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.
Department of Chemistry, The State University of New York at Buffalo, New York, NY 14260, USA.

Mosaad S Mohamed (MS)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.

Samir M Awad (SM)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.
Pharmacy Department, Al-zahrawi University College, Carbala 56001, Iraq.

Amal F Gharib (AF)

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.

Omnia Aly (O)

Medical Biochemistry Department, National Research Centre, Doki, P.O. Box 12622 Cairo, Egypt.

Marwa Abd El-Fattah Khodair (MAE)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.

Samar S Fatahala (SS)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.

Rania H Abd El-Hameed (RHA)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Helwan, Cairo 11795, Egypt.

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Classifications MeSH