Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency: Findings from the SarcoPhAge Cohort.

Humans Vitamin D Deficiency / blood Male Vitamin D / blood Female Biomarkers / blood Aged Cohort Studies Parathyroid Hormone / blood Tandem Mass Spectrometry Aged, 80 and over Belgium Chromatography, Liquid / methods
functional vitamin D deficiency mortality prediction parathyroid hormone (PTH) vitamin D metabolite ratio (VMR)

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
24 Sep 2024
Historique:
received: 30 07 2024
revised: 12 09 2024
accepted: 17 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

The vitamin D metabolite ratio (VMR) has recently been identified as a potentially better indicator of vitamin D deficiency than 25-hydroxyvitamin D (25(OH)D) alone. This study aims to validate these findings by demonstrating that VMR is more strongly correlated with parathyroid hormone (PTH) levels than 25(OH)D and 24,25-dihydroxyvitamin D (24,25(OH) The SarcoPhAge cohort is a Belgian cohort of community-dwelling older adults. Levels of 25(OH)D and 24,25(OH) A total of 35 individuals (17.2%) had 25(OH)D < 20 ng/mL, 40 individuals (19.6%) had 24,25(OH) This study confirms that VMR is an efficient biomarker for assessing functional vitamin D deficiency.

Sections du résumé

BACKGROUND BACKGROUND
The vitamin D metabolite ratio (VMR) has recently been identified as a potentially better indicator of vitamin D deficiency than 25-hydroxyvitamin D (25(OH)D) alone. This study aims to validate these findings by demonstrating that VMR is more strongly correlated with parathyroid hormone (PTH) levels than 25(OH)D and 24,25-dihydroxyvitamin D (24,25(OH)
METHODS METHODS
The SarcoPhAge cohort is a Belgian cohort of community-dwelling older adults. Levels of 25(OH)D and 24,25(OH)
RESULTS RESULTS
A total of 35 individuals (17.2%) had 25(OH)D < 20 ng/mL, 40 individuals (19.6%) had 24,25(OH)
CONCLUSIONS CONCLUSIONS
This study confirms that VMR is an efficient biomarker for assessing functional vitamin D deficiency.

Identifiants

DOI: 10.3390/nu16193224 PMID: 39408192
pubmed: 39408192
pii: nu16193224
doi: 10.3390/nu16193224
pii:
doi:

Substances chimiques

Vitamin D 1406-16-2
Biomarkers 0
25-hydroxyvitamin D A288AR3C9H
Parathyroid Hormone 0
24,25-dihydroxyvitamin D 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : King Saud University
ID : Distinguished Scientists Fellowship Programme of the King Saud University

Auteurs

Aurélie Ladang (A)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.
ORCID: 0000-0002-5316-3108

Anne-Sophie Gendebien (AS)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.

Stéphanie Kovacs (S)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.

Céline Demonceau (C)

Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, 4000 Liège, Belgium.
ORCID: 0000-0001-7089-6605

Charlotte Beaudart (C)

Clinical Pharmacology and Toxicology Research Unit (URPC), NARILIS, Department of Biomedical Sciences, University of Namur, 5000 Namur, Belgium.

Stéphanie Peeters (S)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.

Majed S Alokail (MS)

Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Nasser M Al-Daghri (NM)

Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
ORCID: 0000-0001-5472-1725

Caroline Le Goff (C)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.
ORCID: 0000-0001-7816-3705

Jean-Yves Reginster (JY)

Protein Research Chair, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
ORCID: 0000-0001-6290-752X

Olivier Bruyere (O)

Research Unit in Public Health, Epidemiology and Health Economics, University of Liège, 4000 Liège, Belgium.
Department of Physical Activity and Rehabilitation, University of Liège, 4000 Liège, Belgium.
ORCID: 0000-0003-4269-9393

Etienne Cavalier (E)

Department of Clinical Chemistry, CIRM, CHU de Liège, University of Liège, 4000 Liège, Belgium.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Maladies de carence › Avitaminoses › Carence en vitamine D › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Régions géographiques › Europe › Belgique › Investigation of the Vitamin D Metabolite...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Investigation of the Vitamin D Metabolite...