Exploring Lectin Bioactivity and Total Phenolic Compounds in Kiwifruit (
Actinidia deliciosa var. Hayward
bioactivities
kiwifruit
lectins
phenolic compounds
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
28 Sep 2024
28 Sep 2024
Historique:
received:
12
08
2024
revised:
19
09
2024
accepted:
24
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
The consumption of kiwifruit ( The objective of this work was to evaluate and identify the phenolic compounds in this variety of kiwifruit, as well as to investigate the lectin activity and the potential dietary benefits of this combination. This study quantified and identified total phenolic compounds and flavonoids in a kiwifruit extract using HPLC-DAD-MS/MS, and assessed their antioxidant activity through the DPPH method. Novel lectin activity was also investigated, with polypeptide characterization and glycoprotein profiling performed. The affinity of lectins for glycans was evaluated using a hemagglutination inhibition assay. Results indicated that kiwifruit lectins bind to glycoreceptors on tumor cell membranes, with a specific affinity for sialic acid, an important glycan in tumor-associated glycomic aberrations. These findings suggest that the bioactive components of kiwifruit may offer multiple health benefits through a synergistic effect.
Sections du résumé
BACKGROUND
BACKGROUND
The consumption of kiwifruit (
OBJECTIVES
OBJECTIVE
The objective of this work was to evaluate and identify the phenolic compounds in this variety of kiwifruit, as well as to investigate the lectin activity and the potential dietary benefits of this combination.
METHODS
METHODS
This study quantified and identified total phenolic compounds and flavonoids in a kiwifruit extract using HPLC-DAD-MS/MS, and assessed their antioxidant activity through the DPPH method.
RESULTS
RESULTS
Novel lectin activity was also investigated, with polypeptide characterization and glycoprotein profiling performed. The affinity of lectins for glycans was evaluated using a hemagglutination inhibition assay. Results indicated that kiwifruit lectins bind to glycoreceptors on tumor cell membranes, with a specific affinity for sialic acid, an important glycan in tumor-associated glycomic aberrations.
CONCLUSIONS
CONCLUSIONS
These findings suggest that the bioactive components of kiwifruit may offer multiple health benefits through a synergistic effect.
Identifiants
pubmed: 39408259
pii: nu16193292
doi: 10.3390/nu16193292
pii:
doi:
Substances chimiques
Phenols
0
Antioxidants
0
Plant Extracts
0
Lectins
0
Flavonoids
0
Plant Lectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM