Genetic and Anthropometric Interplay: How Waist-to-Hip Ratio Modulates LDL-c Levels in Mexican Population.
Humans
Female
Male
Polymorphism, Single Nucleotide
Waist-Hip Ratio
Mexico
Adult
Obesity
/ genetics
Middle Aged
Cholesterol, LDL
/ blood
Genetic Predisposition to Disease
Adiponectin
/ blood
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/ genetics
Receptors, Leptin
/ genetics
Risk Factors
Anthropometry
Genotype
ATP Binding Cassette Transporter 1
ABCA1
ADIPOQ
FTO
GRB14
LEPR
SNP
genetic risk score
obesity
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
08 Oct 2024
08 Oct 2024
Historique:
received:
06
09
2024
revised:
26
09
2024
accepted:
04
10
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Genetic factors contribute to the physiopathology of obesity and its comorbidities. This study aimed to investigate the association of the SNPs The study included 396 Mexican mestizo individuals with obesity and 142 individuals with normal weight. Biochemical markers were evaluated from peripheral blood samples, and SNP genotyping was performed using PCR with TaqMan probes. A genetic risk score (GRS) was computed using an additive model. No significant associations were found between the SNPs A significant interaction between genetics and WHR influences LDL-c in Mexicans, which may contribute to the prevention and clinical management of dyslipidemia and cardiovascular disease.
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
Genetic factors contribute to the physiopathology of obesity and its comorbidities. This study aimed to investigate the association of the SNPs
METHODS
METHODS
The study included 396 Mexican mestizo individuals with obesity and 142 individuals with normal weight. Biochemical markers were evaluated from peripheral blood samples, and SNP genotyping was performed using PCR with TaqMan probes. A genetic risk score (GRS) was computed using an additive model.
RESULTS
RESULTS
No significant associations were found between the SNPs
CONCLUSIONS
CONCLUSIONS
A significant interaction between genetics and WHR influences LDL-c in Mexicans, which may contribute to the prevention and clinical management of dyslipidemia and cardiovascular disease.
Identifiants
pubmed: 39408369
pii: nu16193402
doi: 10.3390/nu16193402
pii:
doi:
Substances chimiques
Cholesterol, LDL
0
Adiponectin
0
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
ABCA1 protein, human
0
Receptors, Leptin
0
ADIPOQ protein, human
0
LEPR protein, human
0
ATP Binding Cassette Transporter 1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ibero American University
ID : 17a.-Convocatoria-DINVP