Chromogranin B Protects Human Umbilical Endothelial Cells against Oxidative Stress.
Humans
Oxidative Stress
/ drug effects
Human Umbilical Vein Endothelial Cells
/ metabolism
Membrane Potential, Mitochondrial
/ drug effects
Reactive Oxygen Species
/ metabolism
Cell Survival
/ drug effects
Glutathione
/ metabolism
Nitric Oxide
/ metabolism
Calcium
/ metabolism
Hydrogen Peroxide
/ pharmacology
Cells, Cultured
cardiovascular
granines
mitochondria
nitric oxide
oxidative stress
protection
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
25 Sep 2024
25 Sep 2024
Historique:
received:
13
06
2024
revised:
19
09
2024
accepted:
22
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Chromogranin B (CgB) is involved in the control of the cardiovascular system through the regulation of catecholamine release. Whether CgB can exert direct actions on the endothelium has not yet been clarified. Here, we aimed to investigate the effects of CgB on cell viability, mitochondrial membrane potential, reactive oxygen species (ROS), glutathione (GSH), nitric oxide (NO) release, and the cytosolic calcium concentration ([Ca
Identifiants
pubmed: 39408626
pii: ijms251910296
doi: 10.3390/ijms251910296
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Glutathione
GAN16C9B8O
Nitric Oxide
31C4KY9ESH
Calcium
SY7Q814VUP
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM