Transcriptome Profiling Associated with

Humans Colorectal Neoplasms / genetics CARD Signaling Adaptor Proteins / genetics NF-kappa B / metabolism Tumor Microenvironment / genetics Gene Expression Profiling Gene Expression Regulation, Neoplastic Signal Transduction Guanylate Cyclase / genetics HT29 Cells HCT116 Cells Transcriptome Cell Line, Tumor
CARD11 GSEA NF-κB pathway colorectal cancer tumor immune microenvironment

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
26 Sep 2024
Historique:
received: 01 09 2024
revised: 18 09 2024
accepted: 22 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

The immune system plays a critical role in inflammation by initiating responses to infections or tissue damage. The nuclear factor-κB (NF-κB) pathway plays a key role in inflammation and innate immunity, as well as other cellular activities. Dysregulation of this well-choreographed pathway has been implicated in various diseases, including cancer. CARD11 is a key molecule in the BCL10-MALT1 complex, which is involved in transducing the signal downstream of the NF-κB pathway. This study aims to elucidate how

Identifiants

DOI: 10.3390/ijms251910367 PMID: 39408697
pubmed: 39408697
pii: ijms251910367
doi: 10.3390/ijms251910367
pii:
doi:

Substances chimiques

CARD Signaling Adaptor Proteins 0
NF-kappa B 0
CARD11 protein, human EC 4.6.1.2
Guanylate Cyclase EC 4.6.1.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : ASPIRE Precision Medicine Research Institute grant
ID : VRI-20-10

Auteurs

Faisal Alhosani (F)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Forensic Laboratory Department, Sharjah Police Headquarters, Sharjah P.O. Box 1965, United Arab Emirates.
ORCID: 0000-0002-3553-7217

Burcu Yener Ilce (BY)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
ORCID: 0009-0009-2068-1089

Reem Sami Alhamidi (RS)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
ORCID: 0009-0006-2893-2872

Poorna Manasa Bhamidimarri (PM)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.

Alaa Mohamed Hamad (AM)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
ORCID: 0009-0006-3196-8956

Noura Alkhayyal (N)

Oncology Unit, University Hospital Sharjah, Sharjah P.O. Box 72772, United Arab Emirates.

Axel Künstner (A)

Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
ORCID: 0000-0003-0692-2105

Cyrus Khandanpour (C)

Department of Hematology and Oncology, University Cancer Center Schleswig-Holstein, University Hospital Schleswig-Holstein, University of Lübeck, 23562 Lübeck, Germany.
ORCID: 0000-0003-4655-6269

Hauke Busch (H)

Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
ORCID: 0000-0003-4763-4521

Basel Al-Ramadi (B)

Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Zayed Center for Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
ASPIRE Precision Medicine Research Institute Abu Dhabi, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
ORCID: 0000-0002-1657-1938

Kadria Sayed (K)

Department of Pathology and Laboratory Medicine, American Hospital Dubai, Dubai P.O. Box 3050, United Arab Emirates.

Ali AlFazari (A)

Mediclinic Welcare Hospital, Dubai P.O. Box 31500, United Arab Emirates.

Riyad Bendardaf (R)

Oncology Unit, University Hospital Sharjah, Sharjah P.O. Box 72772, United Arab Emirates.

Rifat Hamoudi (R)

Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Center of Excellence for Precision Medicine, Research Institute of Medical and Health Sciences, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
BIMAI-Lab, Biomedically Informed Artificial Intelligence Laboratory, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
ASPIRE Precision Medicine Research Institute Abu Dhabi, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.
ORCID: 0000-0002-1402-0868

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Transcriptome Profiling Associated with
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Transcriptome Profiling Associated with
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Protéines adaptatrices de signalisation CARD › Transcriptome Profiling Associated with
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteur de transcription NF-kappa B › Transcriptome Profiling Associated with
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Transcriptome Profiling Associated with
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Transcriptome Profiling Associated with
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Transcriptome Profiling Associated with
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Transcriptome Profiling Associated with
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Guanylate cyclase › Transcriptome Profiling Associated with
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HT29 › Transcriptome Profiling Associated with
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellules HCT116 › Transcriptome Profiling Associated with
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Transcriptome Profiling Associated with
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Transcriptome Profiling Associated with