Genomic and Transcriptomic Profile of HNF1A-Mutated Liver Adenomas Highlights Molecular Signature and Potential Therapeutic Implications.

Humans Hepatocyte Nuclear Factor 1-alpha / genetics Male Liver Neoplasms / genetics Transcriptome Adolescent Adenoma, Liver Cell / genetics Mutation Gene Expression Profiling Gene Expression Regulation, Neoplastic Transcription Factors / genetics Genomics / methods DNA-Binding Proteins
HNF1A genetics hepatic adenomas liver molecular signature

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
29 Sep 2024
Historique:
received: 29 08 2024
revised: 15 09 2024
accepted: 25 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Hepatocellular adenomas (HAs) are tumors that can develop under different conditions, including in patients harboring a germline mutation in

Identifiants

DOI: 10.3390/ijms251910483 PMID: 39408812
pubmed: 39408812
pii: ijms251910483
doi: 10.3390/ijms251910483
pii:
doi:

Substances chimiques

Hepatocyte Nuclear Factor 1-alpha 0
HNF1A protein, human 0
Transcription Factors 0
ARID1A protein, human 0
DNA-Binding Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Italian Ministry of Education-University
ID : D15D18000410001

Auteurs

Angelo Corso Faini (AC)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0003-2193-4577

Francesca Arruga (F)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Michele Pinon (M)

Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.

Valeria Bracciamà (V)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Francesco Edoardo Vallone (FE)

Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Fiorenza Mioli (F)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Monica Sorbini (M)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0009-0008-3308-7647

Martina Migliorero (M)

Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Alessandro Gambella (A)

Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
Division of Liver and Transplant Pathology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
ORCID: 0000-0001-7826-002X

Damiano Carota (D)

Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Isaac Giraudo (I)

Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.

Paola Cassoni (P)

Pathology Unit, Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0003-1977-7410

Silvia Catalano (S)

General Surgery 2U, Liver Transplantation Center, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
ORCID: 0000-0001-8370-1846

Renato Romagnoli (R)

General Surgery 2U, Liver Transplantation Center, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
ORCID: 0000-0001-8340-8885

Antonio Amoroso (A)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0002-9437-9407

Pier Luigi Calvo (PL)

Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
ORCID: 0000-0001-9264-3465

Tiziana Vaisitti (T)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0002-3375-6985

Silvia Deaglio (S)

Immunogenetics and Transplant Biology Service, Azienda Ospedaliera-Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
Department of Medical Sciences, University of Turin, 10126 Turin, Italy.
ORCID: 0000-0003-0632-5036

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs nucléaires hépatocytaires › Facteur nucléaire hépatocytaire HNF-1 › Facteur nucléaire hépatocytaire HNF-1 alpha › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Adénome hépatocellulaire › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomic and Transcriptomic Profile of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Genomic and Transcriptomic Profile of...