YKL40/Integrin β4 Axis Induced by the Interaction between Cancer Cells and Tumor-Associated Macrophages Is Involved in the Progression of High-Grade Serous Ovarian Carcinoma.
Humans
Female
Ovarian Neoplasms
/ metabolism
Chitinase-3-Like Protein 1
/ metabolism
Cystadenocarcinoma, Serous
/ metabolism
Tumor-Associated Macrophages
/ metabolism
Cell Proliferation
Disease Progression
Integrin beta4
/ metabolism
Cell Line, Tumor
Cell Movement
Coculture Techniques
Tumor Microenvironment
Middle Aged
Carcinoma, Ovarian Epithelial
/ metabolism
Prognosis
Neoplasm Grading
Signal Transduction
YKL40
epithelial ovarian cancer
high-grade serous ovarian carcinoma
tumor microenvironment
tumor-associated macrophages
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
received:
05
09
2024
revised:
24
09
2024
accepted:
28
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Macrophages in the tumor microenvironment, termed tumor-associated macrophages (TAMs), promote the progression of various cancer types. However, many mechanisms related to tumor-stromal interactions in epithelial ovarian cancer (EOC) progression remain unclear. High-grade serous ovarian carcinoma (HGSOC) is the most malignant EOC subtype. Herein, immunohistochemistry was performed on 65 HGSOC tissue samples, revealing that patients with a higher infiltration of CD68
Identifiants
pubmed: 39408927
pii: ijms251910598
doi: 10.3390/ijms251910598
pii:
doi:
Substances chimiques
Chitinase-3-Like Protein 1
0
CHI3L1 protein, human
0
Integrin beta4
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 20K09643
Organisme : Japan Society for the Promotion of Science
ID : 22K06978