Total Iridoid Glycosides from

Animals Oxidative Stress / drug effects Iridoid Glycosides / pharmacology Receptors, Cytoplasmic and Nuclear / metabolism Cholestasis / metabolism Rats Swertia / chemistry Molecular Docking Simulation Male 1-Naphthylisothiocyanate Rats, Sprague-Dawley
FXR Swertia mussotii Franch. cholestasis iridoid glycosides oxidative stress

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Oct 2024
Historique:
received: 30 08 2024
revised: 30 09 2024
accepted: 30 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Cholestasis refers to a physiological and pathological process caused by bile acid (BA) overaccumulation inside the circulatory system and liver, leading to systemic and hepatocellular damage. Activating the farnesol X receptor (FXR) to restore BA homeostasis is a promising strategy for treating cholestasis. The objective of this research is to reveal solid evidence for the fact that the total iridoid glycosides from

Identifiants

DOI: 10.3390/ijms251910607 PMID: 39408937
pubmed: 39408937
pii: ijms251910607
doi: 10.3390/ijms251910607
pii:
doi:

Substances chimiques

farnesoid X-activated receptor 0C5V0MRU6P
Iridoid Glycosides 0
Receptors, Cytoplasmic and Nuclear 0
1-Naphthylisothiocyanate 551-06-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : the Key project of Chinese Academy of Sciences under Grant
ID : ZDRW-ZS-2020-2
Organisme : Qinghai Provincial Science and Technology Major Project
ID : 2023-SF-A5

Auteurs

Qi Dong (Q)

Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
ORCID: 0000-0002-6192-1597

Zhenhua Wang (Z)

College of Life Sciences, Yantai University, Yantai 264005, China.
ORCID: 0000-0002-7347-8561

Na Hu (N)

Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.

Fangfang Tie (F)

Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.

Zenggen Liu (Z)

Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.

Ying Sun (Y)

College of Life Sciences, Yantai University, Yantai 264005, China.

Yue Wang (Y)

Medical College, Qinghai University, Xining 810016, China.

Nixia Tan (N)

Medical College, Qinghai University, Xining 810016, China.

Honglun Wang (H)

Qinghai Provincial Key Laboratory of Tibetan Medicine Research and CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Xining 810008, China.
ORCID: 0000-0002-9882-9604

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Total Iridoid Glycosides from
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Total Iridoid Glycosides from
questionsmedicales.fr › Glucides › Hétérosides › Glycosides d'iridoïdes › Total Iridoid Glycosides from
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Total Iridoid Glycosides from
questionsmedicales.fr › Maladies de l'appareil digestif › Maladie des voies biliaires › Maladies des canaux biliaires › Cholestase › Total Iridoid Glycosides from
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Total Iridoid Glycosides from
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Gentianales › Gentianaceae › Swertia › Total Iridoid Glycosides from
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Total Iridoid Glycosides from
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › 1-Naphtyl-isothiocyanate › Total Iridoid Glycosides from
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Total Iridoid Glycosides from