Toxicological Evaluation of Kaempferol and Linearolactone as Treatments for Amoebic Liver Abscess Development in

Animals Liver Abscess, Amebic / drug therapy Kaempferols / pharmacology Male Mesocricetus Liver / drug effects Entamoeba histolytica / drug effects Cricetinae Disease Models, Animal Magnetic Resonance Imaging
Entamoeba histolytica Mesocricetus auratus amoebic liver abscess kaempferol linearolactone toxicity

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Oct 2024
Historique:
received: 06 07 2024
revised: 23 09 2024
accepted: 29 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Several studies with kaempferol (KP) and linearolactone (LL) have demonstrated their antiparasitic activity. However, the toxicity of these treatments is unknown. Therefore, this study aimed to evaluate the possible toxicological effects of intraperitoneal (i.p.) administration of KP or LL on the amoebic liver abscess model (ALA) in

Identifiants

DOI: 10.3390/ijms251910633 PMID: 39408962
pubmed: 39408962
pii: ijms251910633
doi: 10.3390/ijms251910633
pii:
doi:

Substances chimiques

Kaempferols 0
kaempferol 731P2LE49E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Consejo Nacional de Humanidades, Ciencias y Tecnologías
ID : CB-2013-01-221136
Organisme : Consejo Nacional de Humanidades, Ciencias y Tecnologías
ID : 103584
Organisme : Consejo Nacional de Humanidades, Ciencias y Tecnologías
ID : 371147

Auteurs

Luis Varela-Rodríguez (L)

Facultad de Ciencias Químicas (FCQ), Universidad Autónoma de Chihuahua (UACH), Chihuahua 31125, CP, Mexico.
ORCID: 0000-0001-8808-8403

Fernando Calzada (F)

Unidad de Investigación Médica en Farmacología, Hospital de Especialidades UMAE-CMNSXXI-IMSS, Ciudad de México 06725, CP, Mexico.
ORCID: 0000-0003-1851-5988

José Antonio Velázquez-Domínguez (JA)

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.
ORCID: 0000-0003-4504-8166

Verónica Ivonne Hernández-Ramírez (VI)

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.
ORCID: 0000-0002-1743-939X

Hugo Varela-Rodríguez (H)

Facultad de Ciencias Químicas (FCQ), Universidad Autónoma de Chihuahua (UACH), Chihuahua 31125, CP, Mexico.
Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua (UACH), Chihuahua 31109, CP, Mexico.
ORCID: 0000-0001-5258-9222

Elihú Bautista (E)

Unidad de Ciencias Ambientales, IPICYT, San Luis Potosí 78216, CP, Mexico.

Mayra Herrera-Martínez (M)

Instituto de Farmacobiología, Universidad de la Cañada (UNCA), Teotitlán de Flores Magón, Oax 68540, CP, Mexico.
ORCID: 0000-0003-1734-9500

Diana Laura Pichardo-Hernández (DL)

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.

Rodrigo Daniel Castellanos-Mijangos (RD)

Unidad de Imagenología Diagnóstica, Centro Médico ISSEMyM-Arturo Montiel Rojas, Metepec 52170, CP, Mexico.

Bibiana Chávez-Munguía (B)

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.

Patricia Talamás-Rohana (P)

Departamento de Infectómica y Patogénesis Molecular, CINVESTAV-IPN, Ciudad de México 07360, CP, Mexico.
ORCID: 0000-0002-5085-814X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Parasitoses hépatiques › Abcès amibien du foie › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Kaempférols › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Mesocricetus › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Système digestif › Foie › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Eucaryotes › Amoebozoa › Lobosea › Amoebida › Tubulina › Entamoeba › Entamoeba histolytica › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Toxicological Evaluation of Kaempferol and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Toxicological Evaluation of Kaempferol and...