Effects of Zinc Phthalocyanine Photodynamic Therapy on Vital Structures and Processes in Hela Cells.
Humans
Photochemotherapy
/ methods
HeLa Cells
Isoindoles
Indoles
/ pharmacology
Zinc Compounds
/ pharmacology
Organometallic Compounds
/ pharmacology
Membrane Potential, Mitochondrial
/ drug effects
Reactive Oxygen Species
/ metabolism
Photosensitizing Agents
/ pharmacology
Oxidative Stress
/ drug effects
DNA Damage
/ drug effects
DNA
liposome
mitochondria
oxidative stress
photodynamic therapy
proteins
reactive oxygen species
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
13
08
2024
revised:
24
09
2024
accepted:
01
10
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
This work presents results on the efficiency of newly designed zinc phthalocyanine-mediated photodynamic therapy of both tumoral and nontumoral cell models using the MTT assay. Further detailed examinations of mechanistic and cell biological effects were focused on the HELA cervical cancer cell model. Here, ROS production, changes in the mitochondrial membrane potential, the determination of genotoxicity, and protein changes determined by capillary chromatography and tandem mass spectrometry with ESI were analyzed. The results showed that, in vitro, 5 Jcm
Identifiants
pubmed: 39408981
pii: ijms251910650
doi: 10.3390/ijms251910650
pii:
doi:
Substances chimiques
Isoindoles
0
Indoles
0
Zinc Compounds
0
Organometallic Compounds
0
Zn(II)-phthalocyanine
14320-04-8
Reactive Oxygen Species
0
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : The Ministry of Health Czech Republic
ID : NU21J-03-00062