Trehalose Attenuates In Vitro Neurotoxicity of 6-Hydroxydopamine by Reducing Oxidative Stress and Activation of MAPK/AMPK Signaling Pathways.
Oxidopamine
/ toxicity
Oxidative Stress
/ drug effects
Trehalose
/ pharmacology
Humans
Cell Line, Tumor
AMP-Activated Protein Kinases
/ metabolism
Neuroprotective Agents
/ pharmacology
Apoptosis
/ drug effects
Signal Transduction
/ drug effects
MAP Kinase Signaling System
/ drug effects
Autophagy
/ drug effects
6-hydroxydopamine
AMP-activated protein kinase
JNK
MPP+
Parkinson’s disease
mitochondrial damage
oxidative stress
p38 MAPK
trehalose
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Oct 2024
03 Oct 2024
Historique:
received:
30
08
2024
revised:
24
09
2024
accepted:
29
09
2024
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
The effects of trehalose, an autophagy-inducing disaccharide with neuroprotective properties, on the neurotoxicity of parkinsonian mimetics 6-hydroxydopamine (6-OHDA) and 1-methyl-4-phenylpiridinium (MPP
Identifiants
pubmed: 39408988
pii: ijms251910659
doi: 10.3390/ijms251910659
pii:
doi:
Substances chimiques
Oxidopamine
8HW4YBZ748
Trehalose
B8WCK70T7I
AMP-Activated Protein Kinases
EC 2.7.11.31
Neuroprotective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science, Technological Development and Innovation, Republic of Serbia
ID : 451-03-47/2023-01/200110
Organisme : Ministry of Science, Technological Development and Innovation, Republic of Serbia
ID : 451-03-66/2024-03/200110
Organisme : Ministry of Science, Technological Development and Innovation, Republic of Serbia
ID : 451-03-66/2024-03/200007