The Expression of Vitamin D Receptor on Peripheral Blood Mononuclear Cells in Patients with Psoriasis.

Humans Psoriasis / blood Receptors, Calcitriol / metabolism Male Female Leukocytes, Mononuclear / metabolism Adult Middle Aged Etanercept / therapeutic use Vitamin D / analogs & derivatives Monocytes / metabolism Lipopolysaccharide Receptors / metabolism Case-Control Studies
CD14+ monocytes CD3+ lymphocytes Psoriasis tumor necrosis factor inhibitor vitamin D vitamin D receptor

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
03 Oct 2024
Historique:
received: 29 08 2024
revised: 20 09 2024
accepted: 27 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Vitamin D plays an important role in psoriasis, but its involvement in pathogenesis remains unclear. This study aimed to evaluate vitamin D receptor (VDR) expression on peripheral blood mononuclear cells (PBMCs) in patients with psoriasis and healthy controls and to study the effects of the Etanercept treatment on VDR expression on PBMCs in patients with psoriasis. Twenty patients with moderate to severe psoriasis received treatment with Etanercept for 24 weeks. The age- and sex-matched controls did not receive any intervention. VDR expression on CD3

Identifiants

DOI: 10.3390/ijms251910677 PMID: 39409006
pubmed: 39409006
pii: ijms251910677
doi: 10.3390/ijms251910677
pii:
doi:

Substances chimiques

Receptors, Calcitriol 0
Etanercept OP401G7OJC
Vitamin D 1406-16-2
VDR protein, human 0
Lipopolysaccharide Receptors 0
25-hydroxyvitamin D A288AR3C9H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Azin Jasmin Zanghaneh (AJ)

Department of Dermatology and Venereology, Västmanlands Sjukhus Västerås, 721 89 Västerås, Sweden.

Andrea Elmelid (A)

Department of Dermatology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Center for Clinical Research, Uppsala University, 791 82 Falun, Sweden.
ORCID: 0000-0002-6349-2757

Martin Gillstedt (M)

Department of Dermatology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Department of Dermatology and Venereology, Sahlgrenska University Hospital, Region Västra Götaland, 413 45 Gothenburg, Sweden.
ORCID: 0000-0001-5033-5421

Omar Ahmic (O)

Accident and Emergency Department, Northern Älvsborg County Hospital, 461 73 Trollhättan, Sweden.

Bengt Andersson (B)

Department of Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital, Region Västra Götaland, 413 45 Gothenburg, Sweden.

Amra Osmancevic (A)

Department of Dermatology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden.
Department of Dermatology and Venereology, Sahlgrenska University Hospital, Region Västra Götaland, 413 45 Gothenburg, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Dermatoses papulosquameuses › Psoriasis › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur calcitriol › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Étanercept › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Monocytes › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Antigènes CD14 › The Expression of Vitamin D Receptor on...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › The Expression of Vitamin D Receptor on...