Structural Insights and Catalytic Mechanism of 3-Hydroxybutyryl-CoA Dehydrogenase from

Faecalibacterium prausnitzii / metabolism Crystallography, X-Ray 3-Hydroxyacyl CoA Dehydrogenases / metabolism NAD / metabolism Models, Molecular Acyl Coenzyme A / metabolism Bacterial Proteins / chemistry Catalytic Domain Protein Conformation
3-hydroxybutyryl-CoA dehydrogenase acetoacetyl-CoA atopic dermatitis open–closed conformation serial femtosecond crystallography

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Oct 2024
Historique:
received: 12 09 2024
revised: 01 10 2024
accepted: 01 10 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Atopic dermatitis (AD) is characterized by a T-helper cell type 2 (Th2) inflammatory response leading to skin damage with erythema and edema. Comparative fecal sample analysis has uncovered a strong correlation between AD and

Identifiants

DOI: 10.3390/ijms251910711 PMID: 39409040
pubmed: 39409040
pii: ijms251910711
doi: 10.3390/ijms251910711
pii:
doi:

Substances chimiques

3-hydroxybutyryl-CoA dehydrogenase EC 1.1.1.157
3-Hydroxyacyl CoA Dehydrogenases EC 1.1.1.-
NAD 0U46U6E8UK
acetoacetyl CoA 1420-36-6
Acyl Coenzyme A 0
Bacterial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Research Foundation of Korea
ID : 2020R1A2C2005670
Organisme : National Research Foundation of Korea
ID : 2022R1I1A1A01068223

Auteurs

Jaewon Yang (J)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Hyung Jin Jeon (HJ)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Seonha Park (S)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
ORCID: 0009-0002-1786-0448

Junga Park (J)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Seonhye Jang (S)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Byeongmin Shin (B)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Kyuhyeon Bang (K)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Hye-Jin Kim Hawkes (HK)

Center for Creative Convergence Education, Hanyang University, Seoul 04763, Republic of Korea.

Sungha Park (S)

Department of Bioengineering, Incheon JEI University, Incheon 21987, Republic of Korea.

Sulhee Kim (S)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Korea BioDefense Research Institute, Korea University, Seoul 02841, Republic of Korea.
ORCID: 0000-0002-8303-1376

Kwang Yeon Hwang (KY)

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.
Korea BioDefense Research Institute, Korea University, Seoul 02841, Republic of Korea.
ORCID: 0000-0002-2076-5030

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Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries anaérobies à Gram négatif › Bâtonnets à Gram négatif anaérobies droits, incurvés et spiralés › Faecalibacterium › Faecalibacterium prausnitzii › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › 3-Hydroxyacyl-CoA dehydrogenases › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Coenzyme A › Acyl coenzyme A › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Structural Insights and Catalytic Mechanism of...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structural Insights and Catalytic Mechanism of...