Synthesis and Preliminary Studies for In Vitro Biological Activity of Two New Water-Soluble Bis(thio)carbohydrazones and Their Copper(II) and Zinc(II) Complexes.

Zinc / chemistry Copper / chemistry Humans Hydrazones / chemistry Coordination Complexes / pharmacology Solubility Water / chemistry Cell Line, Tumor Antineoplastic Agents / pharmacology Ligands Cell Survival / drug effects Crystallography, X-Ray
copper(II) complexes cytotoxic activity metal complexes metallodrugs thiocarbohydrazones

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
09 Oct 2024
Historique:
received: 11 09 2024
revised: 03 10 2024
accepted: 05 10 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Research in the field of metallodrugs is continually increasing. However, it is often limited by the poor solubility in water of the metal complexes. To try to overcome this problem, the two new ligands bis-(sodium 3-methoxy-5-sulfonate-salicylaldehyde)thiocarbohydrazone (

Identifiants

DOI: 10.3390/ijms251910831 PMID: 39409159
pubmed: 39409159
pii: ijms251910831
doi: 10.3390/ijms251910831
pii:
doi:

Substances chimiques

Zinc J41CSQ7QDS
Copper 789U1901C5
Hydrazones 0
Coordination Complexes 0
Water 059QF0KO0R
Antineoplastic Agents 0
Ligands 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : University of Parma
ID : Bando di Ateneo 2023 per la ricerca

Auteurs

Alessio Zavaroni (A)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0000-0002-9761-7247

Elena Riva (E)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0009-0000-7621-3422

Valentina Borghesani (V)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0000-0003-3109-8306

Greta Donati (G)

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy.
ORCID: 0000-0002-0311-1721

Federica Santoro (F)

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy.
ORCID: 0009-0008-0269-2000

Vincenzo Maria D'Amore (VM)

Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Napoli, Italy.
ORCID: 0000-0002-6460-3447

Matteo Tegoni (M)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0000-0002-9621-0410

Giorgio Pelosi (G)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
Centre for Molecular and Translational Oncology, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
ORCID: 0000-0002-7946-0602

Annamaria Buschini (A)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
Centre for Molecular and Translational Oncology, University of Parma, Parco Area delle Scienze 11/A, 43124 Parma, Italy.
ORCID: 0000-0002-9877-2767

Dominga Rogolino (D)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0000-0003-2295-5783

Mauro Carcelli (M)

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 17/A, 43124 Parma, Italy.
ORCID: 0000-0001-5888-4556

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Zinc › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Composés chimiques organiques › Hydrazines › Hydrazones › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Phénomènes chimiques › Solubilité › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Eau › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Synthesis and Preliminary Studies for In Vitro...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Synthesis and Preliminary Studies for In Vitro...