Waxy- or Putty-Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity.

CB1 receptor bioassay MDMB‐INACA new psychoactive substances (NPS) novel drug preparations synthetic cannabinoid receptor agonists (SCRAs)

Journal

Drug testing and analysis
ISSN: 1942-7611
Titre abrégé: Drug Test Anal
Pays: England
ID NLM: 101483449

Informations de publication

Date de publication:
15 Oct 2024
Historique:
revised: 23 09 2024
received: 12 07 2024
accepted: 24 09 2024
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: aheadofprint

Résumé

After the Scottish Prison Service (SPS) introduced mail photocopying procedures in December 2021, a shift in smuggling methods was observed for synthetic cannabinoid receptor agonists (SCRAs) and other new psychoactive substances (NPS) from drug-infused papers back to traditional sample matrices (e.g., tablets and powders), although new matrices also emerged. This study reports on waxy- or putty-like materials as a novel drug preparation for SCRAs and other drugs seized from UK prisons. In 2023, 22 of these new preparations were seized from Scottish prisons, with eight found in sealed vape pods. The materials were positive for SCRAs, phytocannabinoids, novel benzodiazepines, and/or gabapentinoids. Additionally, 11 preparations were seized from an English prison, all containing the SCRAs MDMB-4en-PINACA and MDMB-INACA. MDMB-INACA was pharmacologically characterized using in vitro CB

Identifiants

pubmed: 39410765
doi: 10.1002/dta.3817
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Scottish Prison Service
Organisme : Leverhulme Trust
ID : RC-2015-011
Organisme : Bijzonder Onderzoeksfonds (BOF) of Ghent University
ID : BOF21/DOC/248
Organisme : Research Foundation Flanders
ID : 1S54521N
Organisme : Engineering and Physical Sciences Research Council
ID : EP/V026917/1
Organisme : Engineering and Physical Sciences Research Council
ID : EP/L016354/1
Organisme : Strategic Research Area in Forensic Sciences at Linköping University

Informations de copyright

© 2024 The Author(s). Drug Testing and Analysis published by John Wiley & Sons Ltd.

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Auteurs

Axelle Timmerman (A)

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Marie H Deventer (MH)

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Rachael Andrews (R)

Department of Life Sciences, University of Bath, Bath, UK.

Robert Reid (R)

Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, UK.

Victoria Marland (V)

Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, UK.

Darren Edwards (D)

Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK.

Christopher R Pudney (CR)

Department of Life Sciences, University of Bath, Bath, UK.
Centre for Bioengineering and Biomedical Technologies, University of Bath, Bath, UK.

Niamh Nic Daéid (N)

Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, UK.

Christophe P Stove (CP)

Laboratory of Toxicology, Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Caitlyn Norman (C)

Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Dundee, UK.
Department of Biomedical and Clinical Science, Division of Clinical Chemistry and Pharmacology, Linköping University, Linköping, Sweden.

Classifications MeSH