Exploring the 1-(4-Nitrophenyl)-3-arylprop-2-en-1-one Scaffold for the Selective Inhibition of Monoamine Oxidase B.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
received:
29
05
2024
revised:
04
09
2024
accepted:
10
09
2024
pmc-release:
10
10
2025
medline:
16
10
2024
pubmed:
16
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
A small library of 1-(4-nitrophenyl)-3-arylprop-2-en-1-one derivatives was synthesized to identify new human monoamine oxidase B selective inhibitors. Their inhibitory activity toward MAO-A and MAO-B isoforms was evaluated to determine their potency and selectivity. All newly synthesized compounds were nanomolar inhibitors of the B isoform with IC
Identifiants
pubmed: 39411531
doi: 10.1021/acsmedchemlett.4c00246
pmc: PMC11472546
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1685-1691Informations de copyright
© 2024 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.