Semaphorin 3D promotes pancreatic ductal adenocarcinoma progression and metastasis through macrophage reprogramming.

Animals Carcinoma, Pancreatic Ductal / pathology Semaphorins / metabolism Mice Macrophages / metabolism Pancreatic Neoplasms / pathology Humans Disease Progression Neoplasm Metastasis Proto-Oncogene Proteins p21(ras) / genetics Cell Line, Tumor Cellular Reprogramming Disease Models, Animal

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
18 Oct 2024
Historique:
medline: 16 10 2024
pubmed: 16 10 2024
entrez: 16 10 2024
Statut: ppublish

Résumé

Axon guidance molecules are frequently altered in pancreatic ductal adenocarcinoma (PDA) and influence PDA progression. However, the molecular mechanism remained unclear. Using genetically engineered mouse models to examine semaphorin 3D (SEMA3D), we identified a dual role for tumor- and nerve-derived SEMA3D in the malignant transformation of pancreatic epithelial cells and invasive PDA development. Pancreatic-specific knockout of the SEMA3D gene from the KRAS

Identifiants

DOI: 10.1126/sciadv.adp0684 PMID: 39413197
pubmed: 39413197
doi: 10.1126/sciadv.adp0684
doi:

Substances chimiques

Semaphorins 0
Sema 3D protein, mouse 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp0684

Auteurs

Noelle R J Thielman (NRJ)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0002-2260-8055

Vanessa Funes (V)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0009-0002-1033-5552

Sanjana Davuluri (S)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Molecular Microbiology and Immunology, Johns Hopkins University School of Public Health, Baltimore, MD 21287, USA.
ORCID: 0009-0003-4955-3255

Hector E Ibanez (HE)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0002-8170-4127

Wei-Chih Sun (WC)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0001-8117-0359

Juan Fu (J)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Keyu Li (K)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
ORCID: 0000-0002-4547-4918

Stephen Muth (S)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Xingyi Pan (X)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Kenji Fujiwara (K)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Surgery, Kimura Hospital and Department of Surgery; Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0001-5900-9382
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0003-2069-310X

MacKenzie Henderson (M)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Selina Shiqing Teh (SS)

Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0002-5281-1978

Qingfeng Zhu (Q)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0001-7871-3359

Elizabeth Thompson (E)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0003-4633-843X

Elizabeth M Jaffee (EM)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Skip Viragh Center for Pancreatic Cancer, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Cancer Convergence Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
ORCID: 0000-0003-3841-6549

Alex Kolodkin (A)

Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Fengxi Meng (F)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Shanghai Eye and ENT Hospital, Fudan University, Shanghai 200031, China.

Lei Zheng (L)

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pancreatic Cancer Precision Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Skip Viragh Center for Pancreatic Cancer, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
ORCID: 0000-0003-4163-2541

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Sémaphorines › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Semaphorin 3D promotes pancreatic ductal...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Semaphorin 3D promotes pancreatic ductal...