Fetal body composition reference charts and sexual dimorphism using magnetic resonance imaging.
Body composition
Fat-water magnetic resonance imaging
Fetal magnetic resonance imaging
Magnetic resonance imaging
Preterm infants
Preterm infants nutrition
Sexual dimorphism
Journal
The American journal of clinical nutrition
ISSN: 1938-3207
Titre abrégé: Am J Clin Nutr
Pays: United States
ID NLM: 0376027
Informations de publication
Date de publication:
14 Oct 2024
14 Oct 2024
Historique:
received:
26
03
2024
revised:
12
08
2024
accepted:
07
10
2024
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
16
10
2024
Statut:
aheadofprint
Résumé
The American Academy of Pediatrics advises that the nutrition of preterm infants should target a body composition similar to that of a fetus in utero. Still, reference charts for intrauterine body composition are missing. Moreover, data on sexual differences in intrauterine body composition during pregnancy are limited. The objective of this study was to create reference charts for intrauterine body composition from 30 to 36+6 weeks post-conception and to evaluate the differences between sexes. In this single-center retrospective study, data of 197 normal developing fetuses in late gestation was acquired at 3T magnetic resonance imaging (MRI) scans, including True Fast Imaging with Steady State Free Precession and T Throughout late gestation, BM, FSF, FM, FM%, and FFM increased, while the FFM% decreased. Reference charts and gestational age and sex-specific percentiles are provided. Males exhibited significantly higher BM (7.2%; 95% confidence interval [95% CI], 1.9-12.4%), FFM (8.5%; 95% CI, 3.7- 13.4%), and FFM% (1.2%; 95% CI, 0.6-1.7%) and lower FSF (-3.6%; 95% CI, -5.6-[-1.8]%) and FM% (-1.2%; 95% CI, -1.7-[-0.6]%), (P<0.001) compared with females, with no significant difference in FM between sexes (P=0.126). MRI-derived intrauterine body composition growth charts are valuable for tracking growth in preterm infants. This study demonstrated that sexual differences in body composition are already present in the intrauterine phase.
Sections du résumé
BACKGROUND
BACKGROUND
The American Academy of Pediatrics advises that the nutrition of preterm infants should target a body composition similar to that of a fetus in utero. Still, reference charts for intrauterine body composition are missing. Moreover, data on sexual differences in intrauterine body composition during pregnancy are limited.
OBJECTIVE
OBJECTIVE
The objective of this study was to create reference charts for intrauterine body composition from 30 to 36+6 weeks post-conception and to evaluate the differences between sexes.
METHODS
METHODS
In this single-center retrospective study, data of 197 normal developing fetuses in late gestation was acquired at 3T magnetic resonance imaging (MRI) scans, including True Fast Imaging with Steady State Free Precession and T
RESULTS
RESULTS
Throughout late gestation, BM, FSF, FM, FM%, and FFM increased, while the FFM% decreased. Reference charts and gestational age and sex-specific percentiles are provided. Males exhibited significantly higher BM (7.2%; 95% confidence interval [95% CI], 1.9-12.4%), FFM (8.5%; 95% CI, 3.7- 13.4%), and FFM% (1.2%; 95% CI, 0.6-1.7%) and lower FSF (-3.6%; 95% CI, -5.6-[-1.8]%) and FM% (-1.2%; 95% CI, -1.7-[-0.6]%), (P<0.001) compared with females, with no significant difference in FM between sexes (P=0.126).
CONCLUSIONS
CONCLUSIONS
MRI-derived intrauterine body composition growth charts are valuable for tracking growth in preterm infants. This study demonstrated that sexual differences in body composition are already present in the intrauterine phase.
Identifiants
pubmed: 39414081
pii: S0002-9165(24)00811-6
doi: 10.1016/j.ajcnut.2024.10.004
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Aviad RCabinowich reports financial support was provided by Thrasher Research Fund. Dafna Ben Bashat reports financial support was provided by Israel Innovation Authority. Aviad Rabinowich reports financial support was provided by Tel Aviv University. Dafna Ben Bashat has patent #PCT/IL2022/050204 issued to Israel Patent Office. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.