Glucose Homeostasis and Derangement in Birds.
Avian
Diabetes mellitus
GLUT4
Glucagon
Insulin
Pancreas
Somatostatin
Journal
The veterinary clinics of North America. Exotic animal practice
ISSN: 1558-4232
Titre abrégé: Vet Clin North Am Exot Anim Pract
Pays: United States
ID NLM: 9815628
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
16
10
2024
Statut:
aheadofprint
Résumé
Birds (class Aves) have 1.5 to 2 times higher blood glucose concentrations than mammals of comparable sizes. The reasons for this have been studied and are believed to be multifactorial. There is low expression of insulin receptors, decreased sensitivity of the pancreatic β-cells to glucose, an absent or dysfunctional glucose transporter type 4 pathway, and increased blood glucagon concentrations. Glucagon and somatostatin appear to play a greater role than insulin in glucose homeostasis in birds. Severe hyperglycemia in birds can be attributed to diabetes mellitus, necessitating therapy to prevent short-term and long-term deleterious effects.
Identifiants
pubmed: 39414473
pii: S1094-9194(24)00045-8
doi: 10.1016/j.cvex.2024.07.009
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Disclosure The author has nothing to disclose.