Human PapillomaVirus Vaccine Uptake: Attitudes and Practices Among Moroccan Physicians.
Awareness
Cervical cancer
Factors
HPV vaccine
Physicians’ recommendation
Journal
Journal of cancer education : the official journal of the American Association for Cancer Education
ISSN: 1543-0154
Titre abrégé: J Cancer Educ
Pays: England
ID NLM: 8610343
Informations de publication
Date de publication:
17 Oct 2024
17 Oct 2024
Historique:
accepted:
03
09
2024
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
16
10
2024
Statut:
aheadofprint
Résumé
In Morocco, cervical cancer is a serious public health problem with an estimated number of 2165 new cases and 1199 deaths in 2020. The human papillomavirus (HPV) vaccine has been available in Morocco since 2008. Few data are available on physicians' practices and attitudes toward HPV vaccine. Hence, this study aims to evaluate physicians' awareness and practice towards HPV vaccine and to highlight the main factors affecting physicians' recommendation of this vaccine in Morocco. We have carried out a structured interviewer-administered questionnaire with 500 physicians in different Moroccan regions between March 2019 and March 2020. This study showed an insufficient level of awareness of the two most common types of HPV associated with cervical cancer (36.6%). The rate of HPV vaccine recommendation did not exceed 16.6%. However, more than 63% of participants who were aware of HPV vaccine were willing to recommend it for their future eligible patients. Age (p value < 0.01), sector of activity (p value < 0.01), awareness of the two most common types of HPV associated with genital warts (p value = 0.02), of the vaccine schedules (p value = 0.03), and of the commercial name of this vaccine (p value < 0.01), were significant factors influencing physicians' recommendation of HPV vaccine. Our results showed that, older age (above 51 years old) was associated with negative attitude towards the recommendation of this vaccine (OR: 0.17, 0.06-0.46 CI 95%). Practice in public sector was positively associated with recommendation of HPV vaccine (OR: 7.54, 3.38-16.80 CI 95%). Who were aware of the two most common types of HPV associated with genital warts were more likely to recommend HPV vaccine (OR: 3.36, 1.31-8.65 CI 95%). In the same line, participants, who were also more likely to recommend the vaccine, were those who were aware of HPV vaccine schedules (OR: 6.07, 3.51-10.50 IC 95%); participants who were aware of the commercial name of the HPV vaccine were more likely to recommend the vaccine (OR: 10.04, 5.02-20.09 IC 95%). Indeed, raising physicians' awareness is urgently needed to improve HPV vaccine coverage within Moroccan population.
Identifiants
pubmed: 39414743
doi: 10.1007/s13187-024-02505-x
pii: 10.1007/s13187-024-02505-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Centre for Scientific and Technical Research
ID : 18UHP2019
Informations de copyright
© 2024. The Author(s) under exclusive licence to American Association for Cancer Education.
Références
Global Cancer Observatory. http://gco.iarc.fr/ . Accessed 12 Oct 2019
Registre_des_Cancers_de_la_Region_du_Grand_Casablanca_2013–2017.pdf
Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 189:12–9 (pmid:10451482)
doi: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
pubmed: 10451482
Smith JS, Lindsay L, Hoots B et al (2007) Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical lesions: a meta-analysis update. Int J Cancer 121:621–632. https://doi.org/10.1002/ijc.22527
doi: 10.1002/ijc.22527
pubmed: 17405118
Zhou X, Sun L, Yao X, et al. (2020) Progress in vaccination of prophylactic human papillomavirus vaccine. Front Immunol 11:. https://doi.org/10.3389/fimmu.2020.01434
Lu B, Kumar A, Castellsagué X, Giuliano AR (2011) Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysis. BMC Infect Dis 11:13. https://doi.org/10.1186/1471-2334-11-13
doi: 10.1186/1471-2334-11-13
pubmed: 21226933
pmcid: 3034689
HPV Vaccine Administration | Human papillomavirus vaccination | CDC. https://www.cdc.gov/vaccines/vpd/hpv/hcp/administration.html . Accessed 13 Aug 2020
Gallagher KE, LaMontagne DS, Watson-Jones D (2018) Status of HPV vaccine introduction and barriers to country uptake. Vaccine 36:4761–4767. https://doi.org/10.1016/j.vaccine.2018.02.003
doi: 10.1016/j.vaccine.2018.02.003
pubmed: 29580641
Technical guidance on the Introduction of HPV vaccines in European Union countries – an update. https://www.ecdc.europa.eu/en/publications-data/technical-guidance-introduction-hpv-vaccines-european-union-countries-update . Accessed 13 Aug 2020
Bray F, Ferlay J, Soerjomataram I, et al. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 68:394–424. https://doi.org/10.3322/caac.21492
Programme de détection précoce. https://www.contrelecancer.ma/fr/detection_precoce_action . Accessed 31 Jan 2022
Zraidi M, Ibriz M (2023) Human papillomavirus vaccination in view of the National Cancer Control Plan 2020–2029 in Morocco. The Pan African Medical Journal 45:. https://doi.org/10.11604/pamj.2023.45.115.40004
Finney Rutten LJ, St Sauver JL, Beebe TJ et al (2017) Clinician knowledge, clinician barriers, and perceived parental barriers regarding human papillomavirus vaccination: association with initiation and completion rates. Vaccine 35:164–169. https://doi.org/10.1016/j.vaccine.2016.11.012
doi: 10.1016/j.vaccine.2016.11.012
Hopkins TG, Wood NJ, West RM, Darling JC (2009) UK health professionals’ attitudes and knowledge regarding human papillomavirus (HPV) vaccination: a West Yorkshire Study. J Paediatr Child Health 45:652–655. https://doi.org/10.1111/j.1440-1754.2009.01589.x
doi: 10.1111/j.1440-1754.2009.01589.x
pubmed: 19903250
Riedesel JM, Rosenthal SL, Zimet GD et al (2005) Attitudes about human papillomavirus vaccine among family physicians. J Pediatr Adolesc Gynecol 18:391–398. https://doi.org/10.1016/j.jpag.2005.09.004
doi: 10.1016/j.jpag.2005.09.004
pubmed: 16338604
Berraho M, Fakir SE, Abda N et al (2013) Connaissances et pratiques des médecins vis-à-vis du cancer du col de l’utérus et de l’infection HPV à Fès. Sante Publique 25:351–357
doi: 10.3917/spub.253.0351
pubmed: 24007911
Collange F, Fressard L, Pulcini C et al (2016) General practitioners’ attitudes and behaviors toward HPV vaccination: a French national survey. Vaccine 34:762–768. https://doi.org/10.1016/j.vaccine.2015.12.054
doi: 10.1016/j.vaccine.2015.12.054
pubmed: 26752063
Rosen BL, Shepard A, Kahn JA (2018) US health care clinicians’ knowledge, attitudes, and practices regarding human papillomavirus vaccination: a qualitative systematic review. Acad Pediatr 18:S53–S65. https://doi.org/10.1016/j.acap.2017.10.007
doi: 10.1016/j.acap.2017.10.007
pubmed: 29502639
pmcid: 7305794
Lutringer-Magnin D, Kalecinski J, Barone G et al (2011) Human papillomavirus (HPV) vaccination: perception and practice among French general practitioners in the year since licensing. Vaccine 29:5322–5328. https://doi.org/10.1016/j.vaccine.2011.05.006
doi: 10.1016/j.vaccine.2011.05.006
pubmed: 21616114
Almughais ES, Alfarhan A, Salam M (2018) Awareness of primary health care physicians about human papilloma virus infection and its vaccination: a cross-sectional survey from multiple clinics in Saudi Arabia. Infect Drug Resist 11:2257–2267. https://doi.org/10.2147/IDR.S179642
doi: 10.2147/IDR.S179642
pubmed: 30532560
pmcid: 6245379
Kahn JA, Cooper HP, Vadaparampil ST et al (2009) Human papillomavirus vaccine recommendations and agreement with mandated human papillomavirus vaccination for 11-to-12-year-old girls: a statewide survey of Texas physicians. Cancer Epidemiol Biomarkers Prev 18:2325–2332. https://doi.org/10.1158/1055-9965.EPI-09-0184
doi: 10.1158/1055-9965.EPI-09-0184
pubmed: 19661092
W C, M A, H C, et al. (2019) Awareness regarding cervical cancer, pap smear screening, HPV: cross-sectional study in Lebanese population. BJSTR 22:16908–16912. https://doi.org/10.26717/BJSTR.2019.22.003799
Hoque ME (2016) Factors influencing the recommendation of the human papillomavirus vaccine by South African doctors working in a tertiary hospital. Afr Health Sci 16:567–575. https://doi.org/10.4314/ahs.v16i2.26
doi: 10.4314/ahs.v16i2.26
pubmed: 27605973
pmcid: 4994554
Almazrou S, Saddik B, Jradi H (2020) Knowledge, attitudes, and practices of Saudi physicians regarding cervical cancer and the human papilloma virus vaccine. J Infect Public Health 13:584–590. https://doi.org/10.1016/j.jiph.2019.09.002
doi: 10.1016/j.jiph.2019.09.002
pubmed: 31570271
Mouallif M, Bowyer HL, Festali S et al (2014) Cervical cancer and HPV: awareness and vaccine acceptability among parents in Morocco. Vaccine 32:409–416. https://doi.org/10.1016/j.vaccine.2013.10.069
doi: 10.1016/j.vaccine.2013.10.069
pubmed: 24188754
Bruno DM, Wilson TE, Gany F, Aragones A (2014) Identifying human papillomavirus vaccination practices among primary care providers of minority, low-income and immigrant patient populations. Vaccine 32:4149–4154. https://doi.org/10.1016/j.vaccine.2014.05.058
doi: 10.1016/j.vaccine.2014.05.058
pubmed: 24886959
pmcid: 4107630
Daley MF, Crane LA, Markowitz LE et al (2010) Human papillomavirus vaccination practices: a survey of US physicians 18 months after licensure. Pediatrics 126:425–433. https://doi.org/10.1542/peds.2009-3500
doi: 10.1542/peds.2009-3500
pubmed: 20679306
Bernstein HH, Bocchini JA, COMMITTEE ON INFECTIOUS DISEASES (2017) Practical approaches to optimize adolescent immunization. Pediatrics 139:. https://doi.org/10.1542/peds.2016-4187
Kempe A, O’Leary ST, Markowitz LE, et al. (2019) HPV vaccine delivery practices by primary care physicians. Pediatrics 144: https://doi.org/10.1542/peds.2019-1475
Jensen ME, Hartenbach E, McElroy JA et al (2009) Measuring the attitudes of healthcare providers in Dane County toward adolescent immunization with HPV vaccine. WMJ 108:203–205
pubmed: 19753828
pmcid: 2937262
Young JL, Bernheim RG, Korte JE et al (2011) Human papillomavirus vaccination recommendation may be linked to reimbursement: a survey of Virginia family practitioners and gynecologists. J Pediatr Adolesc Gynecol 24:380–385. https://doi.org/10.1016/j.jpag.2011.06.016
doi: 10.1016/j.jpag.2011.06.016
pubmed: 21906978
Mergler MJ, Omer SB, Pan WKY et al (2013) Are recent medical graduates more skeptical of vaccines? Vaccines (Basel) 1:154–166. https://doi.org/10.3390/vaccines1020154
doi: 10.3390/vaccines1020154
pubmed: 26343964
Vadaparampil ST, Malo TL, Kahn JA et al (2014) Physicians’ human papillomavirus vaccine recommendations, 2009 and 2011. Am J Prev Med 46:80–84. https://doi.org/10.1016/j.amepre.2013.07.009
doi: 10.1016/j.amepre.2013.07.009
pubmed: 24355675
pmcid: 3895928
Anfinan NM (2019) Physician’s knowledge and opinions on human papillomavirus vaccination: a cross-sectional study. Saudi Arabia BMC Health Serv Res 19:963. https://doi.org/10.1186/s12913-019-4756-z
doi: 10.1186/s12913-019-4756-z
pubmed: 31830983
Abi Jaoude J, Khair D, Dagher H et al (2018) Factors associated with human papilloma virus (HPV) vaccine recommendation by physicians in Lebanon, a cross-sectional study. Vaccine 36:7562–7567. https://doi.org/10.1016/j.vaccine.2018.10.065
doi: 10.1016/j.vaccine.2018.10.065
pubmed: 30420044
Setia MS (2016) Methodology series module 3: cross-sectional studies. Indian J Dermatol 61:261–264. https://doi.org/10.4103/0019-5154.182410
doi: 10.4103/0019-5154.182410
pubmed: 27293245
pmcid: 4885177