A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 Oct 2024
17 Oct 2024
Historique:
received:
13
11
2023
accepted:
09
10
2024
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
16
10
2024
Statut:
epublish
Résumé
Fungal pathogens must exhibit strong nutritional plasticity, effectively sensing and utilizing diverse nutrients to support virulence. How the signals generated by nutritional sensing are efficiently translated to the morphogenetic machinery for optimal growth and support of virulence remains incompletely understood. Here, we show that the conserved morphogenesis-related kinase, CotA, imparts isoform-specific control over Aspergillus fumigatus invasive growth in host-mimicking environments and during infection. CotA-mediated invasive growth is responsive to exogenous carbon source quality, with only preferred carbon sources supporting hyphal morphogenesis in a mutant lacking one of two identified protein isoforms. Strikingly, we find that the CotA protein does not regulate, nor is cotA gene expression regulated by, the carbon catabolite repression system. Instead, we show that CotA partially mediates invasive growth in specific carbon sources and virulence through the conserved downstream effector and translational repressor, SsdA. Therefore, A. fumigatus CotA accomplishes its conserved morphogenetic functions to drive pathogenic growth by translating host-relevant carbon source quality signals into morphogenetic outputs for efficient tissue invasive growth.
Identifiants
pubmed: 39414804
doi: 10.1038/s41467-024-53358-3
pii: 10.1038/s41467-024-53358-3
doi:
Substances chimiques
Carbon
7440-44-0
Fungal Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8945Subventions
Organisme : NIAID NIH HHS
ID : R01 AI143197
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI158442
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI178048
Pays : United States
Informations de copyright
© 2024. The Author(s).
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