Evolution of Pfdhps and Pfdhfr mutations before and after adopting seasonal malaria chemoprevention in Nanoro, Burkina Faso.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 10 2024
Historique:
received: 04 06 2024
accepted: 04 10 2024
medline: 17 10 2024
pubmed: 17 10 2024
entrez: 16 10 2024
Statut: epublish

Résumé

Seasonal Malaria Chemoprevention consisting of monthly administration of amodiaquine/sulfadoxine-pyrimethamine to children aged 3-59 months during the transmission season could promote SP-resistance. Mutations in dihydrofolate reductase (Pfdhfr) and dihydropteroate synthase (Pfdhps) genes were assessed before and after SMC adoption in Burkina Faso. A total of 769 dried blood spots were selected from studies conducted in Nanoro, Burkina Faso, between 2010 and 2020. Of those, 299 were pre-SMC (2010-2012) and 470 were post-SMC-samples. Pfdhps and Pfdhfr genes were PCR-amplified and sequenced. A systematic review/meta-analysis of published studies conducted in Burkina Faso (2009-2023) was additionally performed. In Nanoro, the prevalence of Pfdhfr triple mutations (CIRNI) rose from 43.6% pre-SMC to 89.4% post-SMC (p < 0.0001). There was no mutation in Pfdhfr 164 and Pfdhps 540; Pfdhps A437G mutation increased from 63.9% (2010-2012) to 84.7% (2020) (p < 0.0001). The VAGKGS haplotype was 2.8% (2020). Pfdhfr/Pfdhps quintuple mutant IRN-436A437G rose from 18.6% (2010-2012) to 58.3% (2020) (p < 0.0001). Meta-analysis results from Burkina Faso showed an increase in mutations at Pfdhfr N51I, C59R, S108N, and Pfdhps A437G after SMC adoption. Post-SMC, the pyrimethamine-resistance marker prevalence increased, while the sulfadoxine-resistance marker prevalence remained stable. Detection of emerging PfdhpsVAGKGS haplotypes in 2020 underscores the importance of continuous SP-resistance monitoring.

Identifiants

pubmed: 39414909
doi: 10.1038/s41598-024-75369-2
pii: 10.1038/s41598-024-75369-2
doi:

Substances chimiques

Tetrahydrofolate Dehydrogenase EC 1.5.1.3
Dihydropteroate Synthase EC 2.5.1.15
Pyrimethamine Z3614QOX8W
Antimalarials 0
Sulfadoxine 88463U4SM5
fanasil, pyrimethamine drug combination 37338-39-9
Amodiaquine 220236ED28
Protozoan Proteins 0
Drug Combinations 0
DHFR protein, Plasmodium falciparum EC 1.5.1.3

Types de publication

Journal Article Systematic Review Meta-Analysis

Langues

eng

Sous-ensembles de citation

IM

Pagination

24224

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Francis Emmanuel Towanou Bohissou (FET)

Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany.
Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.
Centre de Recherche Entomologique de Cotonou (CREC), Cotonou, Benin.

Paul Sondo (P)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

Juliana Inoue (J)

Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany.

Toussaint Rouamba (T)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

Berenger Kaboré (B)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

Guétawendé Job Wilfried Nassa (GJW)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

A Elisée Sié Kambou (AES)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

Tiampan Edwig Traoré (TE)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso.

Victor Asua (V)

Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany.
Infectious Diseases Research Collaboration, Kampala, Uganda.

Steffen Borrmann (S)

Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany.
Centre de Recherches Médicales de Lambaréné, (CERMEL), Lambaréné, Gabon.

Halidou Tinto (H)

Institut de Recherche en Sciences de la Santé (IRSS)/Clinical Research Unit of Nanoro (CRUN), Nanoro, Burkina Faso. halidoutinto@gmail.com.

Jana Held (J)

Institute of Tropical Medicine, University Hospital Tübingen, Tübingen, Germany. jana.held@uni-tuebingen.de.
German Center for Infection Research (DZIF), Partner Site Tübingen, Tübingen, Germany. jana.held@uni-tuebingen.de.
Centre de Recherches Médicales de Lambaréné, (CERMEL), Lambaréné, Gabon. jana.held@uni-tuebingen.de.

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