Human biomonitoring of essential and toxic trace elements (heavy metals and metalloids) in urine of children, teenagers, and young adults from a Central European Cohort in the Czech Republic.

Heavy metals Human biomonitoring Human exposure Trace elements Urine

Journal

Journal of exposure science & environmental epidemiology
ISSN: 1559-064X
Titre abrégé: J Expo Sci Environ Epidemiol
Pays: United States
ID NLM: 101262796

Informations de publication

Date de publication:
16 Oct 2024
Historique:
received: 24 04 2024
accepted: 27 09 2024
revised: 27 09 2024
medline: 17 10 2024
pubmed: 17 10 2024
entrez: 16 10 2024
Statut: aheadofprint

Résumé

Exposure to toxic trace elements, which include metals and metalloids, can induce adverse health effects, including life-threatening diseases. Conversely, essential trace elements are vital for bodily functions, yet their excessive (or inadequate) intake may pose health risks. Therefore, identifying levels and determinants of exposure to trace elements is crucial for safeguarding human health. The present study analyzed urinary concentrations of 14 trace elements (arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, selenium, thallium, and zinc) and their exposure determinants in 711 individuals, spanning from children to young adults from a Central European population from the Czech Republic. Multivariate linear regression and non-parametric Kruskal-Wallis ANOVA were used to investigate exposure determinants. Estimates of 95th percentile concentrations and confidence intervals were carried out to establish reference values (RV Young adults showed elevated toxic element concentrations, whereas children exhibited higher concentrations of essential elements. Mercury concentrations were associated with both dental amalgam filling count and seafood intake; arsenic concentrations were associated with seafood, rice, and mushroom consumption. Mushroom consumption also influenced lead concentrations. Sex differences were found for cadmium, zinc, nickel, and cobalt. Between 17.9% and 25% of the participants exceeded recommended GV for arsenic, while 2.4% to 2.8% exceeded GV for cadmium. Only one participant exceeded the GV for mercury, and none exceeded GVs for chromium and thallium. Essential trace elements' GVs were surpassed by 38% to 68.5% participants for zinc, 1.3% to 1.8% for molybdenum, and 0.2% to 0.3% for selenium. The present study examines trace element exposure in a Central European population from the Czech Republic, unveiling elevated exposure levels of toxic elements in young adults and essential elements in children. It elucidates key determinants of trace element exposure, including dietary and lifestyle indicators as well as dental amalgam fillings. Additionally, the study establishes novel reference values and a comparison with established health-based human biomonitoring guidance values, which are crucial for public health decision-making. This comprehensive biomonitoring study provides essential data to inform public health policies and interventions.

Sections du résumé

BACKGROUND BACKGROUND
Exposure to toxic trace elements, which include metals and metalloids, can induce adverse health effects, including life-threatening diseases. Conversely, essential trace elements are vital for bodily functions, yet their excessive (or inadequate) intake may pose health risks. Therefore, identifying levels and determinants of exposure to trace elements is crucial for safeguarding human health.
METHODS METHODS
The present study analyzed urinary concentrations of 14 trace elements (arsenic, cadmium, cobalt, chromium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, selenium, thallium, and zinc) and their exposure determinants in 711 individuals, spanning from children to young adults from a Central European population from the Czech Republic. Multivariate linear regression and non-parametric Kruskal-Wallis ANOVA were used to investigate exposure determinants. Estimates of 95th percentile concentrations and confidence intervals were carried out to establish reference values (RV
RESULTS RESULTS
Young adults showed elevated toxic element concentrations, whereas children exhibited higher concentrations of essential elements. Mercury concentrations were associated with both dental amalgam filling count and seafood intake; arsenic concentrations were associated with seafood, rice, and mushroom consumption. Mushroom consumption also influenced lead concentrations. Sex differences were found for cadmium, zinc, nickel, and cobalt. Between 17.9% and 25% of the participants exceeded recommended GV for arsenic, while 2.4% to 2.8% exceeded GV for cadmium. Only one participant exceeded the GV for mercury, and none exceeded GVs for chromium and thallium. Essential trace elements' GVs were surpassed by 38% to 68.5% participants for zinc, 1.3% to 1.8% for molybdenum, and 0.2% to 0.3% for selenium.
IMPACT CONCLUSIONS
The present study examines trace element exposure in a Central European population from the Czech Republic, unveiling elevated exposure levels of toxic elements in young adults and essential elements in children. It elucidates key determinants of trace element exposure, including dietary and lifestyle indicators as well as dental amalgam fillings. Additionally, the study establishes novel reference values and a comparison with established health-based human biomonitoring guidance values, which are crucial for public health decision-making. This comprehensive biomonitoring study provides essential data to inform public health policies and interventions.

Identifiants

DOI: 10.1038/s41370-024-00724-4 PMID: 39414997
pubmed: 39414997
doi: 10.1038/s41370-024-00724-4
pii: 10.1038/s41370-024-00724-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Brij Mohan Sharma (BM)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Institute of Biogeochemistry and Pollutant Dynamics (IBP), ETH Zürich, 8092, Zürich, Switzerland.

Klára Komprdová (K)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic. klara.komprdova@recetox.muni.cz.
ORCID: 0009-0002-5884-3855

Katarína Lörinczová (K)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Jan Kuta (J)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Petra Přibylová (P)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Martin Scheringer (M)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Institute of Biogeochemistry and Pollutant Dynamics (IBP), ETH Zürich, 8092, Zürich, Switzerland.

Ludmila Šebejová (L)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Pavel Piler (P)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Martin Zvonař (M)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.
Faculty of Sports Studies, Masaryk university, Kamenice 753/5, Brno, Czech Republic.

Jana Klánová (J)

RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic.

Classifications MeSH