A prenatal skin atlas reveals immune regulation of human skin morphogenesis.

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
16 Oct 2024

Historique:

received: 04 08 2023

accepted: 28 08 2024

medline: 17 10 2024

pubmed: 17 10 2024

entrez: 16 10 2024

Statut: aheadofprint

Résumé

Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions in morphogenesis is unclear. Here we assembled a comprehensive multi-omics reference atlas of prenatal human skin (7-17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches of the skin. This atlas revealed that crosstalk between non-immune and immune cells underpins the formation of hair follicles, is implicated in scarless wound healing and is crucial for skin angiogenesis. We systematically compared a hair-bearing skin organoid (SkO) model derived from human embryonic stem cells and induced pluripotent stem cells to prenatal and adult skin

Identifiants

DOI: 10.1038/s41586-024-08002-x PMID: 39415002

pubmed: 39415002

doi: 10.1038/s41586-024-08002-x

pii: 10.1038/s41586-024-08002-x

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

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