Arterial stiffness as a novel tool for the early prediction of preeclampsia: a perspective.


Journal

Journal of human hypertension
ISSN: 1476-5527
Titre abrégé: J Hum Hypertens
Pays: England
ID NLM: 8811625

Informations de publication

Date de publication:
16 Oct 2024
Historique:
received: 29 07 2024
accepted: 08 10 2024
revised: 02 10 2024
medline: 17 10 2024
pubmed: 17 10 2024
entrez: 16 10 2024
Statut: aheadofprint

Résumé

Preeclampsia is a leading complication of pregnancy that lacks accurate tools for its early prediction. Improved risk stratification tools early in pregnancy would enable more efficient allocation of limited healthcare resources while ensuring that pregnant women destined to develop preeclampsia receive appropriate care. This brief perspective highlights the current state of first-trimester preeclampsia prediction. We focus on arterial stiffness, an important hemodynamic indicator of vascular health that has shown promising results for improved early prediction of preeclampsia by our and independent research groups. Further, we outline the promise, applicability, and feasibility of integrating arterial stiffness assessments into clinical practice.

Identifiants

pubmed: 39415051
doi: 10.1038/s41371-024-00967-6
pii: 10.1038/s41371-024-00967-6
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Fonds de Recherche du Québec - Santé (Fonds de la recherche en sante du Quebec)
ID : Doctoral Training Award

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Magee LA, Nicolaides KH, von Dadelszen P. Preeclampsia. N Engl J Med. 2022;386:1817–32.
doi: 10.1056/NEJMra2109523 pubmed: 35544388
Phan K, Gomez YH, Gorgui J, El-Messidi A, Gagnon R, Abenhaim HA, et al. Arterial stiffness for the early prediction of pre-eclampsia compared with blood pressure, uterine artery Doppler and angiogenic biomarkers: a prospective cohort study. BJOG: Int J Obstet Gynaecol. 2023;130:932–40.
doi: 10.1111/1471-0528.17430
Phan K, Schiller I, Dendukuri N, Gomez Y-H, Gorgui J, El-Messidi A, et al. A longitudinal analysis of arterial stiffness and wave reflection in preeclampsia: Identification of changepoints. Metabolism. 2021;120:154794.
doi: 10.1016/j.metabol.2021.154794 pubmed: 33971204
Magee LA, Smith GN, Bloch C, Côté A-M, Jain V, Nerenberg K, et al. Guideline No. 426: hypertensive disorders of pregnancy: diagnosis, prediction, prevention, and management. J Obstet Gynaecol Can. 2022;44:547–71.e1.
doi: 10.1016/j.jogc.2022.03.002 pubmed: 35577426
Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222. Obstetrics & Gynecology. 2020;135:e237–e260.
Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, et al. The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: A pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet. 2019;145(Suppl 1):1–33. Erratum in: Int J Gynaecol Obstet. 2019;146:390–391.
MacDonald TM, Walker SP, Hannan NJ, Tong S, Tu’uhevaha J. Clinical tools and biomarkers to predict preeclampsia. EBioMedicine. 2022;75.
Cnossen JS, Vollebregt KC, de Vrieze N, ter Riet G, Mol BW, Franx A, et al. Accuracy of mean arterial pressure and blood pressure measurements in predicting pre-eclampsia: systematic review and meta-analysis. BMJ. 2008;336:1117–20.
doi: 10.1136/bmj.39540.522049.BE pubmed: 18480117 pmcid: 2386627
Tian Y, Yang X. A review of roles of uterine artery doppler in pregnancy complications. Front Med (Lausanne). 2022;9:813343.
doi: 10.3389/fmed.2022.813343 pubmed: 35308523
Matevosyan NR. Predictive accuracy of the first trimester Doppler scan: a meta-study. Wien Med Wochenschr. 2015;165:199–209.
doi: 10.1007/s10354-015-0358-5 pubmed: 26077833
Tan M, Wright D, Syngelaki A, Akolekar R, Cicero S, Janga D, et al. Comparison of diagnostic accuracy of early screening for pre‐eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound Obstet Gynecol. 2018;51:743–50.
doi: 10.1002/uog.19039 pubmed: 29536574
Basaran OE, Guven ESG, Guven S. First trimester fetal thymus volume may predict preeclampsia. Pregnancy Hypertens. 2021;26:116–20.
doi: 10.1016/j.preghy.2021.10.007 pubmed: 34741882
Nuckols VR, Holwerda SW, Luehrs RE, DuBose LE, Stroud AK, Brandt D, et al. Beat-to-beat blood pressure variability in the first trimester is associated with the development of preeclampsia in a prospective cohort: relation with aortic stiffness. Hypertension. 2020;76:1800–7.
doi: 10.1161/HYPERTENSIONAHA.120.15019 pubmed: 32951467
Garg P, Jaryal AK, Kachhawa G, Kriplani A, Deepak KK. Sequential profile of endothelial functions and arterial stiffness in preeclampsia during the course of pregnancy. Pregnancy Hypertens. 2019;18:88–95.
doi: 10.1016/j.preghy.2019.09.013 pubmed: 31585347
Velauthar L, Plana M, Kalidindi M, Zamora J, Thilaganathan B, Illanes S, et al. First‐trimester uterine artery Doppler and adverse pregnancy outcome: a meta‐analysis involving 55974 women. Ultrasound Obstet Gynecol. 2014;43:500–7.
doi: 10.1002/uog.13275 pubmed: 24339044
Kenny LC, Black MA, Poston L, Taylor R, Myers JE, Baker PN, et al. Early pregnancy prediction of preeclampsia in nulliparous women, combining clinical risk and biomarkers: the Screening for Pregnancy Endpoints (SCOPE) international cohort study. Hypertension. 2014;64:644–52.
doi: 10.1161/HYPERTENSIONAHA.114.03578 pubmed: 25122928
O’Gorman N, Wright D, Poon L, Rolnik DL, Syngelaki A, de Alvardo M, et al. Multicenter screening for pre‐eclampsia by maternal factors and biomarkers at 11–13 weeks’ gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol. 2017;49:756–60.
doi: 10.1002/uog.17455 pubmed: 28295782
Sokratous N, Bednorz M, Sarli P, Morillo Montes O, Syngelaki A, Wright A, et al. Screening for pre‐eclampsia by maternal serum glycosylated fibronectin at 11− 13 weeks’ gestation. Ultrasound Obstet Gynecol. 2023;62:504–11.
doi: 10.1002/uog.26303 pubmed: 37401855
Kaufmann P, Mayhew T, Charnock-Jones D. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta. 2004;25:114–26.
doi: 10.1016/j.placenta.2003.10.009 pubmed: 14972444
Burton GJ, Jauniaux E. Placental oxidative stress: from miscarriage to preeclampsia. J Soc Gynecologic Investig. 2004;11:342–52.
doi: 10.1016/j.jsgi.2004.03.003
Chirinos JA, Segers P, Hughes T, Townsend R. Large-artery stiffness in health and disease: JACC state-of-the-art review. J Am Coll Cardiol. 2019;74:1237–63.
doi: 10.1016/j.jacc.2019.07.012 pubmed: 31466622 pmcid: 6719727
Nilsson PM, Boutouyrie P, Laurent S. Vascular aging: a tale of EVA and ADAM in cardiovascular risk assessment and prevention. Hypertension. 2009;54:3–10.
doi: 10.1161/HYPERTENSIONAHA.109.129114 pubmed: 19487587
Murray EC, Delles C, Orzechowski P, Renc P, Sitek A, Wagenaar J, et al. Vascular phenotypes in early hypertension. J Hum Hypertens. 2023;37:898–906.
doi: 10.1038/s41371-022-00794-7 pubmed: 36528682
Mancia G, Kreutz R, Brunström M, Burnier M, Grassi G, Januszewicz A, et al. 2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens. 2023; 41:1874–2071.
Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63:636–46.
doi: 10.1016/j.jacc.2013.09.063 pubmed: 24239664
Salvi P. Pulse waves: How vascular hemodynamics affects blood pressure. 2nd ed. Springer Nature, 2017.
Heusinkveld MH, Delhaas T, Lumens J, Huberts W, Spronck B, Hughes AD, et al. Augmentation index is not a proxy for wave reflection magnitude: mechanistic analysis using a computational model. J Appl Physiol. 2019;127:491–500.
doi: 10.1152/japplphysiol.00769.2018 pubmed: 31161882 pmcid: 6711407
Daskalopoulou SS. Chapter 42 - Arterial stiffness and pulsatile hemodynamics in pregnancy and pregnancy-related vascular complications. In: Chirinos JA, editor. Textbook of Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease: Academic Press; 2022. p. 665-87.
Fraser A, Catov JM. Placental syndromes and long-term risk of hypertension. J Hum Hypertens. 2023;37:671–4.
doi: 10.1038/s41371-023-00802-4 pubmed: 36702879 pmcid: 10403351
Kuate Defo A, Daskalopoulou SS. Alterations in vessel hemodynamics across uncomplicated pregnancy. Am J Hypertens. 2023;36:183–91.
doi: 10.1093/ajh/hpac132 pubmed: 36638267
Garrido-Gomez T, Castillo-Marco N, Cordero T, Simon C. Decidualization resistance in the origin of preeclampsia. Am J Obstet Gynecol. 2022;226:S886–S94.
doi: 10.1016/j.ajog.2020.09.039 pubmed: 33007270
Almaani SJ. Placental growth factor in pre-eclampsia: friend or foe? Kidney Int. 2019;95:730–2.
doi: 10.1016/j.kint.2019.02.002 pubmed: 30904058
Williams D. Pregnancy: a stress test for life. Curr Opin Obstet Gynecol. 2003;15:465–71.
doi: 10.1097/00001703-200312000-00002 pubmed: 14624211
Vyas M, Izzo JL Jr, Lacourciere Y, Arnold JM, Dunlap ME, Amato JL, et al. Augmentation index and central aortic stiffness in middle-aged to elderly individuals. Am J Hypertens. 2007;20:642–7.
doi: 10.1016/j.amjhyper.2007.01.008 pubmed: 17531921

Auteurs

Mekayla Forrest (M)

Vascular Health Unit, Research Institute of McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Maria Matossian (M)

Vascular Health Unit, Research Institute of McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.

Brenda Valdes Sustaita (B)

Vascular Health Unit, Research Institute of McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
Department of Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Helena Papacostas Quintanilla (H)

Vascular Health Unit, Research Institute of McGill University Health Centre (RI-MUHC), Montreal, QC, Canada.
Department of Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada.

Bart Spronck (B)

Department of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.

James Sharman (J)

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Stella S Daskalopoulou (SS)

Vascular Health Unit, Research Institute of McGill University Health Centre (RI-MUHC), Montreal, QC, Canada. stella.daskalopoulou@mcgill.ca.
Division of Experimental Medicine, Department of Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada. stella.daskalopoulou@mcgill.ca.
Department of Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada. stella.daskalopoulou@mcgill.ca.
Division of Internal Medicine, McGill University Health Centre, Montreal, QC, Canada. stella.daskalopoulou@mcgill.ca.

Classifications MeSH