Identification of c[D-Trp-Phe-β-Ala-β-Ala], the First κ-Opioid Receptor-Specific Negative Allosteric Modulator.
Journal
ACS pharmacology & translational science
ISSN: 2575-9108
Titre abrégé: ACS Pharmacol Transl Sci
Pays: United States
ID NLM: 101721411
Informations de publication
Date de publication:
11 Oct 2024
11 Oct 2024
Historique:
received:
19
06
2024
revised:
25
08
2024
accepted:
28
08
2024
pmc-release:
11
09
2025
medline:
17
10
2024
pubmed:
17
10
2024
entrez:
17
10
2024
Statut:
epublish
Résumé
Recently, the fungus secondary metabolite cyclotetrapetide c[Trp-Phe-D-Pro-Phe] (CJ-15,208) and its derivatives deserved some attention for their unusual structure and distinctive in vitro and in vivo activity. These tryptophan-containing noncationic opioid peptides can be truly regarded as versatile picklocks capable of activating all opioid receptors. Intriguingly, minimal modification of the potent κ-opioid receptor (KOR) agonist c[D-Trp-Phe-Gly-β-Ala] (
Identifiants
pubmed: 39416958
doi: 10.1021/acsptsci.4c00372
pmc: PMC11475277
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3192-3204Informations de copyright
© 2024 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.