Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity.

artificial intelligence biotechnology healthy longevity

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
16 Oct 2024
Historique:
received: 03 07 2024
accepted: 23 07 2024
medline: 18 10 2024
pubmed: 18 10 2024
entrez: 17 10 2024
Statut: aheadofprint

Résumé

The recent unprecedented progress in ageing research and drug discovery brings together fundamental research and clinical applications to advance the goal of promoting healthy longevity in the human population. We, from the gathering at the Aging Research and Drug Discovery Meeting in 2023, summarised the latest developments in healthspan biotechnology, with a particular emphasis on artificial intelligence (AI), biomarkers and clocks, geroscience, and clinical trials and interventions for healthy longevity. Moreover, we provide an overview of academic research and the biotech industry focused on targeting ageing as the root of age-related diseases to combat multimorbidity and extend healthspan. We propose that the integration of generative AI, cutting-edge biological technology, and longevity medicine is essential for extending the productive and healthy human lifespan.

Identifiants

DOI: 10.18632/aging.206135 PMID: 39418098
pubmed: 39418098
pii: 206135
doi: 10.18632/aging.206135
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Yu-Xuan Lyu (YX)

Institute of Advanced Biotechnology and School of Medicine, Southern University of Science and Technology, Shenzhen, China.
Max Planck Institute for Biology of Ageing, Cologne, Germany.

Qiang Fu (Q)

Institute of Aging Medicine, College of Pharmacy, Binzhou Medical University, Yantai, China.
Anti-aging Innovation Center, Subei Research Institute at Shanghai Jiaotong University, China.
Shandong Cellogene Pharmaceutics Co. Ltd., Yantai, China.

Dominika Wilczok (D)

Duke Kunshan University, Kunshan, Jiangsu, China.
Duke University, Durham, NC 27708, USA.

Kejun Ying (K)

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02108 USA.

Aaron King (A)

Foresight Institute, San Francisco, CA 91125 USA.

Adam Antebi (A)

Max Planck Institute for Biology of Ageing, Cologne, Germany.
Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Aleksandar Vojta (A)

Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.

Alexandra Stolzing (A)

Centre for Biological Engineering, Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough, UK.

Alexey Moskalev (A)

Institute of Biogerontology, Lobachevsky University, Nizhny Novgorod, Russia.

Anastasia Georgievskaya (A)

HautAI OÜ, Tallinn, Estonia.

Andrea B Maier (AB)

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Andrea Olsen (A)

California Institute of Technology, Pasadena, CA 91125, USA.

Anja Groth (A)

Novo Nordisk Foundation Center for Protein Research (CPR), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Anna Katharina Simon (AK)

Max Delbrück Center for Molecular Medicine, Berlin, Germany.
The Kennedy Institute of Rheumatology, Oxford, UK.

Anne Brunet (A)

Department of Genetics, Stanford University, Stanford, CA 94305, USA.

Aisyah Jamil (A)

Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.

Anton Kulaga (A)

Systems Biology of Aging Group, Institute of Biochemistry of the Romanian Academy, Bucharest, Romania.

Asif Bhatti (A)

America’s Frontier Fund, VA 23320, USA.

Benjamin Yaden (B)

Department of Biology, School of Science, Center for Developmental and Regenerative Biology, Indiana University–Purdue University Indianapolis, Indianapolis, IN 46077, USA.

Bente Klarlund Pedersen (BK)

Centre for Physical Activity Research, Rigshospitalet and University of Copenhagen, Denmark.

Björn Schumacher (B)

Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.

Boris Djordjevic (B)

199 Biotechnologies Ltd., London, United Kingdom.
University College London, London, United Kingdom.

Brian Kennedy (B)

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Chieh Chen (C)

Molecular, Cellular, And Integrative Physiology Interdepartmental Program, University of California Los Angeles, Los Angeles, CA 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Christine Yuan Huang (CY)

Hong Kong Quantum AI Lab, Hong Kong.

Christoph U Correll (CU)

Zucker School of Medicine at Hofstra/Northwell, NY 10001, USA.
Charité – University Medicine, Berlin, Germany.

Coleen T Murphy (CT)

Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ 08540, USA.

Collin Y Ewald (CY)

Laboratory of Extracellular Matrix Regeneration, Institute of Translational Medicine, Department of Health Sciences and Technology, ETH Zürich, Schwerzenbach CH-8603, Switzerland.

Danica Chen (D)

Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Metabolic Biology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.
Endocrinology Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA.

Dario Riccardo Valenzano (DR)

Leibniz Institute on Aging, Fritz Lipmann Institute, Friedrich Schiller University, Jena, Germany.

Dariusz Sołdacki (D)

Longevity Center Europe, Warsaw, Poland.

David Erritzoe (D)

Centre for Psychedelic Research, Dpt Brain Sciences, Imperial College London, UK.

David Meyer (D)

Institute for Genome Stability in Aging and Disease, CECAD Research Center, University and University Hospital of Cologne, Cologne 50931, Germany.

David A Sinclair (DA)

Blavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 02108, USA.

Eduardo Nunes Chini (EN)

Signal Transduction and Molecular Nutrition Laboratory, Kogod Aging Center, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, MN 55902, USA.

Emma C Teeling (EC)

School of Biology and Environmental Science, Belfield, University College Dublin, Dublin 4, Ireland.

Eric Morgen (E)

BioAge Labs, Richmond, CA 94530, USA.

Eric Verdin (E)

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Erik Vernet (E)

Research and Early Development, Maaleov 2760, Denmark.

Estefano Pinilla (E)

VitaDAO, Ottawa, ON K1V 9K6, Canada.

Evandro F Fang (EF)

Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway.

Evelyne Bischof (E)

Department of Medical Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Evi M Mercken (EM)

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen 2200, Denmark.

Fabian Finger (F)

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen N 2200, Denmark.

Folkert Kuipers (F)

European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Frank W Pun (FW)

Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.

Gabor Gyülveszi (G)

Rejuveron Life Sciences AG, 8952 Schlieren, Switzerland.

Gabriele Civiletto (G)

Health, Nutrition and Care, DSM-Firmenich, Kaiseraugst, Switzerland.

Garri Zmudze (G)

LongeVC, Riga, Latvia.

Gil Blander (G)

InsideTracker, Cambridge, MA 02114, USA.

Harold A Pincus (HA)

Department of Psychiatry, Columbia University, New York, NY 10012, USA.

Joshua McClure (J)

Maxwell Biosciences, Austin, TX 73301, USA.

James L Kirkland (JL)

Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

James Peyer (J)

Cambrian Bio, Inc., New York, NY 10012, USA.

Jamie N Justice (JN)

XPRIZE Foundation, Culver City, CA 90230, USA.

Jan Vijg (J)

Department of Genetics Albert Einstein College of Medicine, NY 10461, USA.

Jennifer R Gruhn (JR)

Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jerry McLaughlin (J)

Life Biosciences, Boston, MA 02116, USA.

Joan Mannick (J)

Tornado Therapeutics, Cambrian Bio Inc. PipeCo, New York, NY 10012, USA.

João Passos (J)

Department of Physiology and Biomedical Engineering and Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Joseph A Baur (JA)

Department of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19019, USA.

Joe Betts-LaCroix (J)

Retro Biosciences, Inc., Redwood City, CA 94061, USA.

John M Sedivy (JM)

Center on the Biology of Aging, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02860, USA.

John R Speakman (JR)

Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Jordan Shlain (J)

Private Medical, San Francisco, CA 94107, USA.

Julia von Maltzahn (J)

Faculty of Health Sciences Brandenburg and Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg 01968, Germany.

Katrin I Andreasson (KI)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Kelsey Moody (K)

Ichor Life Sciences, Inc., LaFayette, NY 13084, USA.

Konstantinos Palikaras (K)

Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Kristen Fortney (K)

BioAge Labs, Richmond, CA 94530, USA.

Laura J Niedernhofer (LJ)

Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55414, USA.

Lene Juel Rasmussen (LJ)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

Liesbeth M Veenhoff (LM)

European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Lisa Melton (L)

Nature Biotechnology, Springer Nature, London, UK.

Luigi Ferrucci (L)

Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21201, USA.

Marco Quarta (M)

Rubedo Life Sciences, Sunnyvale, CA 94043, USA.
Turn Biotechnologies, Mountain View, CA 94039, USA.
Phaedon Institute, Oakland, CA 94501, USA.

Maria Koval (M)

Institute of Biochemistry of the Romanian Academy, Romania.

Maria Marinova (M)

Fertility and Research Centre, Discipline of Women’s Health, School of Clinical Medicine, University of New South Wales, Sydney, New South Wales, Australia.

Mark Hamalainen (M)

Longevity Biotech Fellowship, Longevity Acceleration Fund, Vitalism, SF Bay, CA 94101, USA.

Maximilian Unfried (M)

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117608, Singapore.

Michael S Ringel (MS)

Boston Consulting Group, Boston, MA 02210, USA.

Milos Filipovic (M)

Leibniz-Institut Für Analytische Wissenschaften-ISAS-E.V., Dortmund, Germany.

Mourad Topors (M)

Repair Biotechnologies, Inc., Syracuse, NY 13210, USA.

Natalia Mitin (N)

Sapere Bio, Triangle Research Park, NC 27213, USA.

Nawal Roy (N)

Holmusk, New York, NY 10012, USA.

Nika Pintar (N)

AniBiome, Zagreb, Croatia.

Nir Barzilai (N)

Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10452, USA.

Paolo Binetti (P)

VitaDAO, Ottawa, ON K1V 9K6, Canada.

Parminder Singh (P)

Buck Institute for Research on Aging, Novato, CA 94945, USA.

Paul Kohlhaas (P)

Molecule, Neuhausen am Rheinfall, Switzerland.

Paul D Robbins (PD)

Institute on the Biology of Aging and Metabolism and the Department of Biochemistry, Molecular Biology, and Biochemistry, University of Minnesota, Minneapolis, MN 55111, USA.

Paul Rubin (P)

BioAge Labs, Richmond, CA 94530, USA.

Peter O Fedichev (PO)

Gero PTE, Singapore, Singapore.

Petrina Kamya (P)

Insilico Medicine Canada Inc., Montreal, Quebec H3B 4W8, Canada.

Pura Muñoz-Canoves (P)

Altos Labs Inc., San Diego Institute of Science, San Diego, CA 92121, USA.

Rafael de Cabo (R)

Translational Gerontology Branch, Intramural Research Program, National Institute on Aging (NIH), Baltimore, MD 21201, USA.

Richard G A Faragher (RGA)

Huxley Building, School of Applied Sciences, University of Brighton, Brighton, UK.

Rob Konrad (R)

Biolytica, Zug, Switzerland.

Roberto Ripa (R)

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Robin Mansukhani (R)

Deciduous Therapeutics, San Francisco, CA 94107, USA.

Sabrina Büttner (S)

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm 10691, Sweden.

Sara A Wickström (SA)

Department of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, Münster, Germany.

Sebastian Brunemeier (S)

Healthspan Capital, El Cerrito, CA 94530, USA.

Sergey Jakimov (S)

LongeVC, Riga, Latvia.

Shan Luo (S)

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.

Sharon Rosenzweig-Lipson (S)

Life Biosciences, Boston, MA 02116, USA.

Shih-Yin Tsai (SY)

Department of Physiology, Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Stefanie Dimmeler (S)

Institute of Cardiovascular Regeneration, Center of Molecular Medicine, Goethe University Frankfurt, Germany.

Thomas A Rando (TA)

Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.

Tim R Peterson (TR)

Bioio, Inc. 4340 Duncan Ave St. Louis, MO 63110, USA.

Tina Woods (T)

Collider Heath, London, UK.
Healthy Longevity Champion, National Innovation Centre for Ageing, UK.

Tony Wyss-Coray (T)

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA.

Toren Finkel (T)

Aging Institute, University of Pittsburgh School of Medicine Pittsburgh, PA 15106 USA.

Tzipora Strauss (T)

Sheba Longevity Center, Sheba Medical Center, Tel Hashomer, Israel.
Tel Aviv Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Vadim N Gladyshev (VN)

Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02108 USA.

Valter D Longo (VD)

Longevity Institute, Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90001, USA.

Varun B Dwaraka (VB)

TruDiagnostic, Lexington, KY 40503, USA.

Vera Gorbunova (V)

Department of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.

Victoria A Acosta-Rodríguez (VA)

Department of Neuroscience, Peter O’Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.

Vincenzo Sorrentino (V)

Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Vittorio Sebastiano (V)

Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA 94301, USA.

Wenbin Li (W)

Department of Neuro-Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.

Yousin Suh (Y)

Department of Obstetrics and Gynecology, Columbia University, New York City, NY 10032, USA.

Alex Zhavoronkov (A)

Insilico Medicine AI Limited, Level 6, Masdar City, Abu Dhabi, UAE.

Morten Scheibye-Knudsen (M)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

Daniela Bakula (D)

Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark.

Classifications MeSH