Adenosine 2A Receptors Link Astrocytic Alpha-1 Adrenergic Signaling to Wake-Promoting Dopamine Neurons.
Astrocytes
adenosine A(2A) receptor
alpha1-adrenergic receptor
arousal
dopamine neurons
norepinephrine
sleep-wake regulation
ventral periaqueductal gray
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
15 Oct 2024
15 Oct 2024
Historique:
received:
20
03
2024
revised:
19
09
2024
accepted:
30
09
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
17
10
2024
Statut:
aheadofprint
Résumé
Sleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via alpha-1 adrenergic receptor (α In this study, we utilized genetic manipulations with ex vivo calcium imaging in vPAG Activation of α We have identified a crucial role for vPAG astrocytic α
Sections du résumé
BACKGROUND
BACKGROUND
Sleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via alpha-1 adrenergic receptor (α
METHODS
METHODS
In this study, we utilized genetic manipulations with ex vivo calcium imaging in vPAG
RESULTS
RESULTS
Activation of α
CONCLUSIONS
CONCLUSIONS
We have identified a crucial role for vPAG astrocytic α
Identifiants
pubmed: 39419462
pii: S0006-3223(24)01663-9
doi: 10.1016/j.biopsych.2024.09.030
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.