Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease.

Cardiovascular disease Insulin-like growth factors PAPP-A

Journal

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society

ISSN: 1532-2238

Titre abrégé: Growth Horm IGF Res

Pays: Scotland

ID NLM: 9814320

Informations de publication

Date de publication:
09 Oct 2024

Historique:

received: 07 08 2024

revised: 25 09 2024

accepted: 04 10 2024

medline: 18 10 2024

pubmed: 18 10 2024

entrez: 17 10 2024

Statut: aheadofprint

Résumé

There is strong evidence that PAPP-A, a local regulator of insulin-like growth factor signaling through proteolytic cleavage of inhibitory binding proteins, is involved in multiple physiological processes associated with cardiovascular disease. This review will describe the various roles of PAPP-A with a focus on atherosclerosis, neointimal hyperplasia, and acute coronary syndrome in animal models and in humans.

Identifiants

DOI: 10.1016/j.ghir.2024.101625 PMID: 39419664

pubmed: 39419664

pii: S1096-6374(24)00055-8

doi: 10.1016/j.ghir.2024.101625

pii:

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

101625

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of competing interest The author declare no competing interests.