A tissue bandage for pelvic ganglia injury.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 Oct 2024
17 Oct 2024
Historique:
received:
21
10
2023
accepted:
08
10
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
17
10
2024
Statut:
epublish
Résumé
Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals' quality of life. Unfortunately, there are currently no effective treatments available for this type of injury. Here, we designed a fiber-enhanced tissue bandage for injured pelvic ganglia. Tight junctions formed in tissue bandages create a mini tissue structure that enhances resistance in an in vivo environment and delivers growth factors to support the healing of ganglia. Strength fibers are similar to clinical bandages and guarantee ease of handling. Furthermore, tissue bandages can be stored at low temperatures over 5 months without compromising cell viability, meeting the requirements for clinical products. A tissue bandage was applied to a male rat with a bilateral major pelvic ganglia crush injury. Compared to the severe neurogenic bladder symptoms observed in the injury and scaffold groups, tissue bandages significantly improved bladder function. We found that tissue bandage increases resistance to mechanical injury by boosting the expression of cytoskeletal proteins within the major pelvic ganglia. Overall, tissue bandages show promise as a practical therapeutic approach for ganglia repair, offering hope for developing more effective treatments for this thorny condition.
Identifiants
pubmed: 39419980
doi: 10.1038/s41467-024-53302-5
pii: 10.1038/s41467-024-53302-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8972Subventions
Organisme : China National Funds for Distinguished Young Scientists
ID : No. 52325504
Organisme : China National Funds for Distinguished Young Scientists
ID : No. 52325504
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : No. 52235007
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : T2121004
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : No. 52235007
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : T2121004
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : No. 81971363
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : No. 81971363
Informations de copyright
© 2024. The Author(s).
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