Riboflavin for women's health and emerging microbiome strategies.
Journal
NPJ biofilms and microbiomes
ISSN: 2055-5008
Titre abrégé: NPJ Biofilms Microbiomes
Pays: United States
ID NLM: 101666944
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
02
07
2024
accepted:
06
10
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
17
10
2024
Statut:
epublish
Résumé
Riboflavin (vitamin B2) is an essential water-soluble vitamin that serves as a precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). FMN and FAD are coenzymes involved in key enzymatic reactions in energy metabolism, biosynthesis, detoxification and electron scavenging pathways. Riboflavin deficiency is prevalent worldwide and impacts women's health due to riboflavin demands linked to urogenital and reproductive health, hormonal fluctuations during the menstrual cycle, pregnancy, and breastfeeding. Innovative functional foods and nutraceuticals are increasingly developed to meet women's riboflavin needs to supplement dietary sources. An emerging and particularly promising strategy is the administration of riboflavin-producing lactic acid bacteria, combining the health benefits of riboflavin with those of probiotics and in situ riboflavin production. Specific taxa of lactobacilli are of particular interest for women, because of the crucial role of Lactobacillus species in the vagina and the documented health effects of other Lactobacillaceae taxa in the gut and on the skin. In this narrative review, we synthesize the underlying molecular mechanisms and clinical benefits of riboflavin intake for women's health, and evaluate the synergistic potential of riboflavin-producing lactobacilli and other microbiota.
Identifiants
pubmed: 39420006
doi: 10.1038/s41522-024-00579-5
pii: 10.1038/s41522-024-00579-5
doi:
Substances chimiques
Riboflavin
TLM2976OFR
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
107Subventions
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : Lacto-Be
Informations de copyright
© 2024. The Author(s).
Références
Bartley, K. A., Underwood, B. A. & Deckelbaum, R. J. A life cycle micronutrient perspective for women’s health. Am. J. Clin. Nutr. 81, 1188–1193 (2005).
doi: 10.1093/ajcn/81.5.1188
Han, S. J. & Kim, H. W. Nutritional status and women’s Health in university students. Information 20, 1795–1803 (2017).
Torheim, L. E., Ferguson, E. L., Penrose, K. & Arimond, M. Women in resource-poor settings are at risk of inadequate intakes of multiple micronutrients. J. Nutr. 140, 2051–2058 (2010).
doi: 10.3945/jn.110.123463
Swaminathan, S., Thomas, T. & Kurpad, A. V. B-vitamin interventions for women and children in low-income populations. Curr. Opin. Clin. Nutr. Metab. Care 18, 295–306 (2015).
pubmed: 25807352
doi: 10.1097/MCO.0000000000000166
Suwannasom, N., Kao, I., Pruß, A., Georgieva, R. & Bäumler, H. Riboflavin: the health benefits of a forgotten natural vitamin. Int. J. Mol. Sci. 21, 950–972 (2020).
Zempleni, J., Link, G. & Bitsch, I. Intrauterine Vitamin B, Uptake of Preterm and Full-Term Infants Vol. 38 (International Pediatric Research Foundation, Inc, 1995).
Mosegaard, S. et al. Riboflavin deficiency—Implications for general human health and inborn errors of metabolism. Int. J. Mol. Sci. 21, 3847 (2020).
Turck, D. et al. Dietary reference values for riboflavin. EFSA J. 15, 4919–4984 (2017).
Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, O. B. V. and C. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin and choline. In Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline 592 (National Academies Press, 1998).
The United Nations University. Recommended dietary intakes and allowances around the world- an introduction. Food Nutr. Bull. 4, 1–14 (1982).
doi: 10.1177/156482658200400415
Powers, H. J. Riboflavin (vitamin B-2) and health. Am. J. Clin. Nutr. 77, 1352–1360 (2003).
Ter Borg, S. et al. Micronutrient intakes and potential inadequacies of community-dwelling older adults: a systematic review. Br. J. Nutr. 113, 1195–1206 (2015).
pubmed: 25822905
pmcid: 4531469
doi: 10.1017/S0007114515000203
Whitfield, K. C. et al. Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia. J. Nutr. 145, 628–633 (2015).
pubmed: 25733481
doi: 10.3945/jn.114.203604
Rohner, F., Zimmermann, M. B., Wegmueller, R., Tschannen, A. B. & Hurrell, R. F. Mild riboflavin deficiency is highly prevalent in school-age children but does not increase risk for anaemia in Côte d’Ivoire. Br. J. Nutr. 97, 970–976 (2007).
pubmed: 17381972
doi: 10.1017/S0007114507665180
Potdar, R. D. et al. Improving women’s diet quality preconceptionally and during gestation: Effects on birth weight and prevalence of low birth weight—A randomized controlled efficacy trial in India (Mumbai maternal nutrition project). Am. J. Clin. Nutr. 100, 1257–1268 (2014).
pubmed: 25332324
pmcid: 4196482
doi: 10.3945/ajcn.114.084921
Drewnowski, A., Henry, C. J. & Dwyer, J. T. Proposed nutrient standards for plant-based beverages intended as milk alternatives. Front. Nutr. 8, 761442 (2021).
Park, Y. W. The impact of plant-based non-dairy alternative milk on the dairy industry. Food Sci. Anim. Resour. 41, 8–15 (2021).
pubmed: 33506213
pmcid: 7810394
doi: 10.5851/kosfa.2020.e82
Ghimeray, P. S. et al. Riboflavin bioavailability varies with milk type and is altered in self-reported dairy intolerance states (P24-012-19). Curr. Dev. Nutr. 3, nzz044.P24–012-19 (2019).
doi: 10.1093/cdn/nzz044.P24-012-19
McKinley, M. C., McNulty, H., McPartlin, J., Strain, J. J. & Scott, J. M. Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status. Eur. J. Clin. Nutr. 56, 850–856 (2002).
pubmed: 12209373
doi: 10.1038/sj.ejcn.1601402
Capo-chichi, C. D. et al. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am. J. Clin. Nutr. 69, 672–678 (1999).
pubmed: 10197568
doi: 10.1093/ajcn/69.4.672
Langohr, H. D., Petruch, F. & Schroth, G. Vitamin B 1, B 2 and B 6 deficiency in neurological disorders. J. Neurol. 225, 95–108 (1981).
Aljaadi, A. M. et al. Suboptimal biochemical riboflavin status is associated with lower hemoglobin and higher rates of anemia in a sample of Canadian and Malaysian women of reproductive age. J. Nutr. 149, 1952–1959 (2019).
pubmed: 31318024
doi: 10.1093/jn/nxz151
European Food Safety Authority. Scientific Opinion on the substantiation of health claims related to riboflavin (vitamin B2). EFSA J. 8, 1814 (2010).
Elsen, C. et al. Vitamins E, A and B2 as possible risk factors for preeclampsia under consideration of the PROPER study (‘prevention of preeclampsia by high-dose riboflavin supplementation’). Geburtshilfe Frauenheilkd. 72, 846–852 (2012).
pubmed: 25308984
pmcid: 4168367
doi: 10.1055/s-0032-1315365
Duffy, B. et al. Impact of riboflavin status on haemoglobin and risk of anaemia in pregnancy. Proc. Nutr. Soc. 80, (2021).
Marashly, E. T. & Bohlega, S. A. Riboflavin has neuroprotective potential: focus on Parkinson’s disease and migraine. Front. Neurol. https://doi.org/10.3389/fneur.2017.00333 (2017).
Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K. & Arakawa, M. Dietary folate, riboflavin, vitamin B6, and vitamin B12 and depressive symptoms in early adolescence: the Ryukyu child health study. Psychosom. Med. 72, 763–768 (2010).
pubmed: 20716710
doi: 10.1097/PSY.0b013e3181f02f15
Lin, Y. H. et al. Association between postpartum nutritional status and postpartum depression symptoms. Nutrients 11, 1204–1217 (2019).
Hill, M. J. Intestinal flora and endogenous vitamin synthesis. Eur. J. Cancer Prev. 6, s41–s43 (1997).
LeBlanc, J. G. et al. Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr. Opin. Biotechnol. 24, 160–168 (2013).
pubmed: 22940212
doi: 10.1016/j.copbio.2012.08.005
Thakur, K., Tomar, S. K. & De, S. Lactic acid bacteria as a cell factory for riboflavin production. Microbial. Biotechnol. 9, 441–451 (2016).
Chu, R., Li, R., Wang, C. & Ban, R. Production of vitamin B2 (riboflavin) by Bacillus subtilis. J. Chem. Technol. Biotechnol. 97, 1941–1949 (2022).
Liu, B. et al. Escherichia coli O157:H7 senses microbiota-produced riboflavin to increase its virulence in the gut. Proc. Natl Acad. Sci. USA 119, e2212436119 (2022).
Magnúsdóttir, S., Ravcheev, D., De Crécy-Lagard, V. & Thiele, I. Systematic genome assessment of B-vitamin biosynthesis suggests cooperation among gut microbes. Front. Genet. 6, 148 (2015).
Toubal, A. & Lehuen, A. Role of MAIT cells in metabolic diseases. Mol. Immunol. 130, 142–147 (2021).
pubmed: 33358570
doi: 10.1016/j.molimm.2020.12.014
Spacova, I. et al. Spontaneous riboflavin-overproducing Limosilactobacillus reuteri for biofortification of fermented foods. Front. Nutr. 9, (2022).
Fiesack, S. et al. Belgian consensus recommendations to prevent vitamin K deficiency bleeding in the term and preterm infant. Nutrients https://doi.org/10.3390/nu13114109 (2021).
Lienhart, W. D., Gudipati, V. & Macheroux, P. The human flavoproteome. Arch. Biochem. Biophys. 535, 150–162 (2013).
pubmed: 23500531
doi: 10.1016/j.abb.2013.02.015
Ross, N. S. & Hansen, T. P. Riboflavin deficiency is associated with selective preservation of critical flavoenzyme-dependent metabolic pathways. BioFactors 3, 185–190 (1992).
pubmed: 1599612
Fischer, M. & Bacher, A. Biosynthesis of flavocoenzymes. Nat. Prod. Rep. 22, 324–350 (2005).
pubmed: 16010344
doi: 10.1039/b210142b
Lopez-Anaya, A. & Mayersohn, M. Quantification of riboflavin, riboflavin 5′-phosphate and flavin adenine dinucleotide in plasma and urine by high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 423, 105–113 (1987).
doi: 10.1016/0378-4347(87)80332-8
Ashoori, M. & Saedisomeolia, A. Riboflavin (vitamin B2) and oxidative stress: a review. Brit. J. Nutr. 111, 1985–1991 (2014).
Dey, S. & Bishayi, B. Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls Staphylococcus aureus infection by boosting murine macrophage function and regulates inflammation. J. Inflamm. 13, 1–21 (2016).
doi: 10.1186/s12950-016-0145-0
Olfat, N., Ashoori, M. & Saedisomeolia, A. Riboflavin is an antioxidant: a review update. Br. J. Nutr. 128, 1887–1895 (2022).
pubmed: 35115064
doi: 10.1017/S0007114521005031
Qureshi, A. A. et al. Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models. Lipids Health Dis. 10, (2011).
Liu, T., Zhang, L., Joo, D. & Sun, S. C. NF-κB signaling in inflammation. Signal Transduct. Target. Ther. 2, 17023 (2017).
Ahn, H. & Lee, G. S. Riboflavin, vitamin B2, attenuates NLRP3, NLRC4, AIM2, and non-canonical inflammasomes by the inhibition of caspase-1 activity. Sci. Rep. 10, 19091 (2020).
Menezes, R. R., Godin, A. M., Rodrigues, F. F. & Coura, G. M. E. Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund’s adjuvant. Pharmacol. Rep. 69, 1036–1043 (2017).
pubmed: 28958614
doi: 10.1016/j.pharep.2017.04.011
Shih, C. K. et al. Riboflavin protects mice against liposaccharide-induced shock through expression of heat shock protein 25. Food Chem. Toxicol. 48, 1913–1918 (2010).
pubmed: 20430062
doi: 10.1016/j.fct.2010.04.033
Toyosawa, T., Suzuki, M., Kodama, K. & Araki, S. Potentiation by amino acid of the therapeutic effect of highly purified vitamin B2 in mice with lipopolysaccharide-induced shock. Eur. J. Pharm. 493, 177–182 (2004).
doi: 10.1016/j.ejphar.2004.04.019
Pinto, J. T. & Cooper, A. J. L. From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D. Adv. Nutr. 5, 144–163 (2014).
Von Martels, J. Z. H. et al. Riboflavin supplementation in patients with Crohn’s disease [the RISE-UP study]. J. Crohns Colitis 14, 595–607 (2020).
doi: 10.1093/ecco-jcc/jjz208
Bourgonje, A. R. et al. The effect of riboflavin supplementation on the systemic redox status in healthy volunteers: a post-hoc analysis of the RIBOGUT trial. Free Radic. Biol. Med. 190, 169–178 (2022).
pubmed: 35973668
doi: 10.1016/j.freeradbiomed.2022.08.008
Bjørke-Monsen, A. L. et al. Impact of pre-pregnancy BMI on B vitamin and inflammatory status in early pregnancy: an observational cohort study. Nutrients 8, 776 (2016).
DiBaise, M. & Tarleton, S. M. Hair, nails, and skin: differentiating cutaneous manifestations of micronutrient deficiency. Nutr. Clin. Pract. 34, 490–503 (2019).
pubmed: 31144371
doi: 10.1002/ncp.10321
Struble, M. B. Nutrition Guide for Physicians (2010).
Henderson, L. M., Koski, R. E. & D’angelis, F. The role of riboflavin and vitamin B6 in tryptophan metabolism. J. Biol. Chem. 215, 369–376 (1954).
Philips, N., Chalensouk-Khaosaat, J. & Gonzalez, S. Simulation of the elastin and fibrillin in non-irradiated or UVA radiated fibroblasts, and direct inhibition of elastase or matrix metalloptoteinases activity by nicotinamide or its derivatives. J. Cosmet. Sci. 69, 47–56 (2018).
pubmed: 29658877
Murakami, K., Miyake, Y., Sasaki, S., Tanaka, K. & Arakawa, M. Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus child health study. Psychosom. Med. 72, 763–768 (2010).
pubmed: 20716710
doi: 10.1097/PSY.0b013e3181f02f15
Chocano-Bedoya, P. O. et al. Dietary B vitamin intake and incident premenstrual syndrome. Am. J. Clin. Nutr. 93, 1080–1086 (2011).
pubmed: 21346091
pmcid: 3076657
doi: 10.3945/ajcn.110.009530
Rouhani, P. et al. Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study. Sci. Rep. 13, (2023).
Borges-Vieira, J. G. & Cardoso, C. K. S. Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials. Nutr. Neurosci. 26, 187–207 (2022).
pubmed: 35156551
doi: 10.1080/1028415X.2022.2031494
Cerri, S., Mus, L. & Blandini, F. Parkinson’s disease in women and men: what’s the difference? J. Parkinson’s Dis. 9, 501–515 (2019).
Solla, P. et al. Gender differences in motor and non-motor symptoms among Sardinian patients with Parkinson’s disease. J. Neurol. Sci. 323, 33–39 (2012).
pubmed: 22935408
doi: 10.1016/j.jns.2012.07.026
Coimbra, C. G. & Junqueira, V. B. C. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson’s disease patients. Braz. J. Med. Biol. Res. 36, 1409–1417 (2003).
Chen, Y. S. et al. Effect of vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis. Nutr. Neurosci. 25, 1801–1812 (2021).
pubmed: 33779525
doi: 10.1080/1028415X.2021.1904542
Vetvik, K. G. & MacGregor, E. A. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 16, 76 (2017).
pubmed: 27836433
doi: 10.1016/S1474-4422(16)30293-9
Kim, K. et al. Dietary intakes of vitamin B2 (riboflavin), vitamin B6, and vitamin B12 and ovarian cycle function among premenopausal women. J. Acad. Nutr. Diet. 120, 885–892 (2020).
pubmed: 31879178
doi: 10.1016/j.jand.2019.10.013
van Casteren, D. S., Verhagen, I. E., Onderwater, G. L. J., MaassenVanDenBrink, A. & Terwindt, G. M. Sex differences in prevalence of migraine trigger factors: a cross-sectional study. Cephalalgia 41, 643–648 (2021).
pubmed: 33203218
doi: 10.1177/0333102420974362
Venkatesan, T. et al. Guidelines on management of cyclic vomiting syndrome in adults by the American Neurogastroenterology and Motility Society and the Cyclic Vomiting Syndrome Association. Neurogastroenterol. Motil. https://doi.org/10.1111/nmo.13604 (2019).
Zhang, M. et al. Biomimetic remodeling of microglial riboflavin metabolism ameliorates cognitive impairment by modulating neuroinflammation. Adv. Sci. 10, e2300180 (2023).
Silva-Araújo, E. R. D. et al. Effects of riboflavin in the treatment of brain damage caused by oxygen deprivation: an integrative systematic review. Nutr. Neurosci. 27, 989–1007 (2024).
Stipanuk, M. H. & Caudill M. A. In Biochemical, Physiological, and Molecular Aspects of Human Nutrition (Elsevier Health Sciences, 2006).
Moretti, R. & Caruso, P. The controversial role of homocysteine in neurology: From labs to clinical practice. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20010231 (2019).
Martami, F. & Holton, K. F. Targeting glutamate neurotoxicity through dietary manipulation: potential treatment for migraine. Nutrients https://doi.org/10.3390/nu15183952 (2023).
Ogunleye, A. J. & Odutuga, A. A. The effect of riboflavin deficiency on cerebrum and cerebellum of developing rat brain. J. Nutr. Sci. Vitaminol. 35, 193–197 (1989).
Naghashpour, M. et al. Brain-derived neurotrophic and immunologic factors: beneficial effects of riboflavin on motor disability in murine model of multiple sclerosis. Iran. J. Basic Med. Sci. 19, 439–448 (2016).
pubmed: 27279989
pmcid: 4887718
Stahler, E. The effect of lactoflavin, vitamin B2, on biology of the vagina. Z. Vitam. Forsch. 10, 26–31 (1940).
Lebeer, S. et al. A citizen-science-enabled catalogue of the vaginal microbiome and associated factors. Nat. Microbiol. 8, 2183–2195 (2023).
pubmed: 37884815
pmcid: 10627828
doi: 10.1038/s41564-023-01500-0
Petrova, M. I., Lievens, E., Malik, S., Imholz, N. & Lebeer, S. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front. Physiol. https://doi.org/10.3389/fphys.2015.00081 (2015).
Sun, M. G., Huang, Y., Xu, Y. H. & Cao, Y. X. Efficacy of vitamin B complex as an adjuvant therapy for the treatment of complicated vulvovaginal candidiasis: an in vivo and in vitro study. Biomed. Pharmacother. 88, 770–777 (2017).
Allonsius, C. N. et al. Interplay between Lactobacillus rhamnosus GG and Candida and the involvement of exopolysaccharides. Micro. Biotechnol. 10, 1753–1763 (2017).
doi: 10.1111/1751-7915.12799
Allonsius, C. N. et al. Inhibition of Candida albicans morphogenesis by chitinase from Lactobacillus rhamnosus GG. Sci. Rep. 9, 2900–2912 (2019).
Spacova, I. et al. Multifactorial inhibition of Candida albicans by combinations of lactobacilli and probiotic Saccharomyces cerevisiae CNCM I-3856. Sci. Rep. 14, 9365–9376 (2024).
Oerlemans, E. F. M. et al. Impact of a lactobacilli-containing gel on vulvovaginal candidosis and the vaginal microbiome. Sci. Rep. 10, 7976–7986 (2020).
Foraker, A. B., Khantwal, C. M. & Swaan, P. W. Current perspectives on the cellular uptake and trafficking of riboflavin. Adv. Drug Deliv. Rev. 55, 1467–1483 (2003).
pubmed: 14597141
doi: 10.1016/j.addr.2003.07.005
Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A. & Willett, W. C. Use of multivitamins, intake of B vitamins and risk of ovulatory infertility. Fertil. Steril. 89, 668–676 (2008).
Maman, E., Adashi, E. Y., Baum, M. & Hourvitz, A. Prediction of ovulation: new insight into an old challenge. Sci. Rep. 13, 20003–20013 (2023).
Miller, W. L. Minireview: Regulation of steroidogenesis by electron transfer. Endocrinology 146, 2544–2550 (2005).
Hecht, S. et al. Common 677C→T mutation of the 5,10-methylenetetrahydrofolate reductase gene affects follicular estradiol synthesis. Fertil. Steril. 91, 56–61 (2009).
pubmed: 18249399
doi: 10.1016/j.fertnstert.2007.11.011
Thaler, C. J., Budiman, H., Ruebsamen, H., Nagel, D. & Lohse, P. Effects of the common 677C>T mutation of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene on ovarian responsiveness to recombinant follicle-stimulating hormone. Am. J. Reprod. Immunol. 55, 251–258 (2006).
pubmed: 16533336
doi: 10.1111/j.1600-0897.2005.00357.x
Rosen, M. P. et al. Methylenetetrahydrofolate reductase (MTHFR) is associated with ovarian follicular activity. Fertil. Steril. 88, 632–638 (2007).
pubmed: 17572411
doi: 10.1016/j.fertnstert.2006.11.165
Stühlinger, M. C. et al. Homocysteine impairs the nitric oxide synthase pathway role of asymmetric dimethylarginine. Basic Sci. Rep. 104, 2569–2575 (2001).
Bajic, Z. et al. Homocysteine, vitamins B6 and folic acid in experimental models of myocardial infarction and heart failure—How strong is that link? Biomolecule https://doi.org/10.3390/biom12040536 (2022).
Altmäe, S., Laanpere, M., Campoy, C. & Salumets, A. In Handbook of Diet and Nutrition in the Menstrual Cycle, Periconception and Fertility 431–448 (Brill | Wageningen Academic, 2014).
Gaskins, A. J. et al. Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am. J. Clin. Nutr. 102, 943–950 (2015).
pubmed: 26354529
pmcid: 4588741
doi: 10.3945/ajcn.115.112185
Zhang, L. et al. Status of maternal serum B vitamins and pregnancy outcomes: new insights from in vitro fertilization and embryo transfer (IVF-ET) treatment. Front. Nutr. 9, 962212 (2022).
Kim, Y. Y. et al. Modulatory effects of single and complex vitamins on the in vitro growth of murine ovarian follicles. Tissue Eng. Regen. Med. 16, 275–283 (2019).
Innis, W. S., McCormick, D. B. & Merrill, A. H. Variations in riboflavin binding by human plasma: identification of immunoglobulins as the major proteins responsible. Biochem Med. 34, 151–165 (1985).
pubmed: 4084240
doi: 10.1016/0006-2944(85)90106-1
Combs, G. F. & McClung, J. P. The Vitamins 315–329 (2017).
van Herwaarden, A. E. et al. Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk. Mol. Cell Biol. 27, 1247–1253 (2007).
pubmed: 17145775
doi: 10.1128/MCB.01621-06
Hampel, D. et al. Thiamin and riboflavin in human milk: effects of lipid-based nutrient supplementation and stage of lactation on vitamer secretion and contributions to total vitamin content. PLoS ONE 11, e0149479 (2016).
Subramanian, S. et al. Immunocontraceptive efficacy of synthetic peptides corresponding to major antigenic determinants of chicken riboflavin carrier protein in the female rats. Am. J. Reprod. Immunol. 44, 184–191 (2000).
pubmed: 11028906
doi: 10.1111/j.8755-8920.2000.4403184.x
Rao, J., Seshagiri, P. B., Shetty, G., Ramesh, G. & Adiga, P. R. Active immunization against riboflavin carrier protein results in peri-implantation embryonic loss leading to pregnancy termination in rats: use of alternate adjuvants. Indian J. Exp. Biol. 38, 863–872 (2000).
pubmed: 12561942
Kohil, A. et al. Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review. Front Nutr. 9, 927972 (2022).
Kuang, W. et al. SLC22A14 is a mitochondrial riboflavin transporter required for sperm oxidative phosphorylation and male fertility. Cell Rep. 35, 109025 (2021).
pubmed: 33882315
pmcid: 8065176
doi: 10.1016/j.celrep.2021.109025
Briggs, M. & Briggs, M. Oral contraceptives and vitamin nutrition. Lancet 303, 1234–1235 (1974).
doi: 10.1016/S0140-6736(74)91054-X
Newman, L. J., Lopez, R., Cole, H. S., Boria, M. C. & Cooperman, J. M. Riboflavin deficiency in women taking oral contraceptive agents. Am. J. Clin. Nutr. 31, 247–249 (1978).
pubmed: 623047
doi: 10.1093/ajcn/31.2.247
Basciani, S. & Porcaro, G. Counteracting side effects of combined oral contraceptives through the administration of specific micronutrients. Eur Rev Med Pharmacol Sci. 26, 4846–4862 (2022).
Palmery, M., Saraceno, A., Vaiarelli, A. & Carlomagno, G. Oral contraceptives and changes in nutritional requirements. Eur. Rev. Med Pharm. Sci. 17, 1804–1813 (2013).
Ahmed, F. & Bamji, M. S. Biochemical basis for the “riboflavin defect” associated with the use of oral contraceptives, a study in female rats. Contraception 14, 297–307 (1976).
pubmed: 10133
doi: 10.1016/0010-7824(76)90097-4
Adams, J. B., Kirby, J. K., Sorensen, J. C., Pollard, E. L. & Audhya, T. Evidence based recommendations for an optimal prenatal supplement for women in the US: vitamins and related nutrients. Matern. Health Neonatol. Perinatol. 8, 4–41 (2022).
Torreggiani, C. et al. Premature farrowing and stillbirths in two organic sow farms due to riboflavin deficiency. Porcine Health Manag. 9, 12–20 (2023).
Wynn, P. C., Morgan, A. J. & Sheehy, P. A. In Encyclopedia of Dairy Sciences: Second Edition 795–800 (2011).
O’Toole, F., Sheane, R., Reynaud, N., McAuliffe, F. M. & Walsh, J. M. Screening and treatment of iron deficiency anemia in pregnancy: A review and appraisal of current international guidelines. Int. J. Gynecol. Obstetr. https://doi.org/10.1002/ijgo.15270 (2023).
Powers, H. J. et al. Correcting a marginal riboflavin deficiency improves hematologic status in young women in the United Kingdom (RIBOFEM). Am. J. Clin. Nutr. 93, 1274–1284 (2011).
pubmed: 21525198
doi: 10.3945/ajcn.110.008409
Aljaadi, A. M., Devlin, A. M. & Green, T. J. Riboflavin intake and status and relationship to anemia. Nutr. Rev. 81, 114–132 (2023).
doi: 10.1093/nutrit/nuac043
Ulvik, R. J. Reduction of exogenous flavins and mobilization of iron from ferritin by isolated mitochondria. J. Bioenerg. Biomembr. 15, 151–160 (1983).
Crossley, R. A. et al. Riboflavin biosynthesis is associated with assimilatory ferric reduction and iron acquisition by Campylobacter jejuni. Appl. Environ. Microbiol. 73, 7819–7825 (2007).
pubmed: 17965203
pmcid: 2168145
doi: 10.1128/AEM.01919-07
Orrico, F. et al. Oxidative stress in healthy and pathological red blood cells. Biomolecules https://doi.org/10.3390/biom13081262 (2023).
Foy, H., Kondi, A. & Verjee, Z. H. Relation of riboflavin deficiency to corticosteroid metabolism and red cell hypoplasia in baboons. J. Nutr. 102, 571–582 (1972).
pubmed: 4622279
doi: 10.1093/jn/102.4.571
Suprapto, B., Widardo & Suhanantyo. Effect of low-dosage vitamin A and riboflavin on iron-folate supplementation in anaemic pregnant women. Asia Pac. J. Clin. Nutr. 11, 263–267 (2002).
pubmed: 12495257
doi: 10.1046/j.1440-6047.2002.00310.x
Magee, L. A., Nicolaides, K. H., & von Dadelszen, P. Preeclampsia. N. Engl. J. Med. 389, 1817–1832 (2022).
doi: 10.1056/NEJMra2109523
Molina, L. et al. PROPER: a pilot study of the Role of Riboflavin Supplementation for the Prevention of Preeclampsia. Int. J. Biol. Biomed. Eng. 6, 43–50 (2012).
Mcnulty, H., Strain, J. J., Hughes, C. F., Pentieva, K. & Ward, M. Evidence of a role for one-carbon metabolism in blood pressure: can B vitamin intervention address the genetic risk of hypertension owing to a common folate polymorphism? Curr. Dev. Nutr. 4, nzz102 (2019).
Masenga, G. G., Shayo, B. C. & Rasch, V. Prevalence and risk factors for pelvic organ prolapse in Kilimanjaro, Tanzania: a population based study in Tanzanian rural community. PLoS ONE 13, 1–13 (2018).
doi: 10.1371/journal.pone.0195910
Elneil, S. Complex pelvic floor failure and associated problems. Best. Pr. Res. Clin. Gastroenterol. 23, 555–573 (2009).
doi: 10.1016/j.bpg.2009.04.011
Schultz, K. J. et al. UVA-photoactivated riboflavin treatment of vaginal cells derived from pelvic organ prolapse cases. Gynecol. Obstet. Invest. 77, 100–103 (2014).
pubmed: 24503625
doi: 10.1159/000357617
McMillan, K. S., Siddighi, S., Hardesty, J. S., Yune, J. J. & Chan, P. J. UVA-photoactivated riboflavin effect on isolated vaginal tissues derived from pelvic organ prolapse cases. Int Urol. Nephrol. 47, 75–79 (2015).
pubmed: 25218617
doi: 10.1007/s11255-014-0836-5
Gogola, A. et al. Spatial patterns and age-related changes of the collagen crimp in the human cornea and sclera. Invest Ophthalmol. Vis. Sci. 59, 2987–2998 (2018).
pubmed: 30025116
pmcid: 5995484
doi: 10.1167/iovs.17-23474
Yyorimoto, Y. Age-related changes in the elastic properties and thickness of human facial skin. Brit. J. Dermatol. 131, 641–648 (1994).
Schuh, C. M. A. P. et al. Nanomechanical and molecular characterization of aging in dentinal collagen. J. Dent. Res. 101, 840–847 (2022).
pubmed: 35130787
doi: 10.1177/00220345211072484
Kang, Y., Kim, J. H., Kim, S. Y., Koh, W. G. & Lee, H. J. Blue light-activated riboflavin phosphate promotes collagen crosslinking to modify the properties of connective tissues. Materials 14, 5788–5799 (2021).
Uemura, R. et al. UVA-activated riboflavin promotes collagen crosslinking to prevent root caries. Sci. Rep. 9, 1252–1263 (2019).
Wu, D. et al. Corneal cross-linking: the evolution of treatment for corneal diseases. Front. Pharmacol. https://doi.org/10.3389/fphar.2021.686630 (2021).
Ibusuki, S. et al. Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. Tissue Eng. 13, 1995–2001 (2007).
pubmed: 17518705
doi: 10.1089/ten.2006.0153
Brock, K. E. et al. Nutrients in diet and plasma and risk of in situ cervical cancer. J. Natl Cancer Inst. 80, 580–585 (1988).
Hernandez, B. Y. et al. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control 14, 859–B870 (2003).
pubmed: 14682443
doi: 10.1023/B:CACO.0000003841.54413.98
Liu, T. et al. A case control study of nutritional factors and cervical dysplasia. Cancer Epidemiol., Biomark. Prev. 2, 525–530 (1993).
Aili, A. et al. Association of the plasma and tissue riboflavin levels with C20orf54 expression in cervical lesions and its relationship to HPV16 infection. PLoS ONE 8, e79937 (2013).
Prusty, B. K. & Das, B. C. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Int. J. Cancer 113, 951–960 (2005).
pubmed: 15514944
doi: 10.1002/ijc.20668
Rösl, F. et al. Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription. J. Virol. 71, 362–370 (1997).
pubmed: 8985358
pmcid: 191059
doi: 10.1128/jvi.71.1.362-370.1997
Zeng, J. et al. Association between one-carbon metabolism-related vitamins and risk of breast cancer: a systematic review and meta-analysis of prospective studies. Clin. Breast Cancer 20, e469–e480 (2020).
pubmed: 32241696
doi: 10.1016/j.clbc.2020.02.012
Van de Roovaart, H., Stevens, M. & Goodridge, A. Safety and efficacy of vitamin B in cancer treatments: a systematic review. J. Oncol. Pharm. Pract. 30, 451–463 (2024).
pubmed: 37231628
doi: 10.1177/10781552231178686
Berginc, K. Pharmacokinetic Interactions between Drugs and Dietary Supplements: Carbohydrate, Protein, Vitamin and Mineral Supplements. Dietary Supplements: Safety, Efficacy and Quality (Woodhead Publishing Limited, 2015).
Ravel, J. et al. Vaginal microbiome of reproductive-age women. Proc. Natl Acad. Sci. USA 108, 4680–4687 (2011).
pubmed: 20534435
doi: 10.1073/pnas.1002611107
Drell, T. et al. Characterization of the vaginal micro- and mycobiome in asymptomatic reproductive-age Estonian women. PLoS ONE 8, (2013).
Lennard, K. et al. Microbial composition predicts genital tract inflammation and persistent bacterial vaginosis in South African adolescent females. Infect. Immun. 86, e00410–17 (2018).
Mehta, S. D. et al. Host genetic factors associated with vaginal microbiome composition in Kenyan women. mSystems 5, e00502-20 (2020).
Symul, L. et al. Sub-communities of the vaginal microbiota in pregnant and non-pregnant women. Proc. R. Soc. B: Biol. Sci. 290, 20231461 (2023).
Gudnadottir, U. et al. The vaginal microbiome and the risk of preterm birth: a systematic review and network meta-analysis. Sci. Rep. 12, 7926–7934 (2022).
van de Wijgert, J. & Verwijs, M. C. Lactobacilli-containing vaginal probiotics to cure or prevent bacterial or fungal vaginal dysbiosis: a systematic review and recommendations for future trial designs. BJOG 127, 287–299 (2020).
pubmed: 31299136
doi: 10.1111/1471-0528.15870
Norenhag, J. et al. The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG 127, 171–180 (2020).
pubmed: 31237400
doi: 10.1111/1471-0528.15854
Turnbaugh, P., Ley, R. & Mahowald, M. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027–1031 (2006).
Wang, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (2012).
pubmed: 23023125
doi: 10.1038/nature11450
Karlsson, F. H. et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99–103 (2013).
pubmed: 23719380
doi: 10.1038/nature12198
Yoshii, K., Hosomi, K., Sawane, K. & Kunisawa, J. Metabolism of dietary and microbial vitamin B family in the regulation of host immunity. Front Nutr. 6, 1–12 (2019).
doi: 10.3389/fnut.2019.00048
Haase, I., Mörtl, S., Köhler, P., Bacher, A. & Fischer, M. Biosynthesis of riboflavin in Archaea 6,7-dimethyl-8-ribityllumazine synthase of Methanococcus jannaschii. Eur. J. Biochem. 270, 1025–1032 (2003).
pubmed: 12603336
doi: 10.1046/j.1432-1033.2003.03478.x
Kalingan, A. E. The kinetics of riboflavin secretion by Eremothecium ashbyii nrrl 1363. Bioprocess Eng. 18, 445–449 (1998).
doi: 10.1007/s004490050469
Averianova, L. A., Balabanova, L. A., Son, O. M., Podvolotskaya, A. B. & Tekutyeva, L. A. Production of vitamin B2 (Riboflavin) by microorganisms: an overview. Front. Bioeng. Biotechnol. 8, 570828 (2020).
pubmed: 33304888
doi: 10.3389/fbioe.2020.570828
Bacher, A., Eberhardt, S., Fischer, M., Kis, K. & Richter, G. Biosynthesis of vitamin B2 (riboflavin). Annu. Rev. Nutr. 20, 153–167 (2000).
pubmed: 10940330
doi: 10.1146/annurev.nutr.20.1.153
Stahmann, K. P., Revuelta, J. L. & Seulberger, H. Three biotechnical processes using Ashbya gossypii, Candida famata, or Bacillus subtilis compete with chemical riboflavin production. Appl. Microbiol. Biotechnol. 53, 509–516 (2000).
pubmed: 10855708
doi: 10.1007/s002530051649
Rychen, G. et al. Safety of vitamin B2 (80%) as riboflavin produced by Bacillus subtilis KCCM-10445 for all animal species. EFSA J. 16, e05223 (2018).
Burdock, G. A. & Carabin, I. G. Generally recognized as safe (GRAS): history and description. Toxicol. Lett. 150, 3–18 (2004).
pubmed: 15068820
doi: 10.1016/j.toxlet.2003.07.004
Leuschner, R. G. K. et al. Qualified presumption of safety (QPS): a generic risk assessment approach for biological agents notified to the European Food Safety Authority (EFSA). Trend. Food Sci. Technol. 21, 425–435 (2010).
Hill, C. et al. Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506–514 (2014).
pubmed: 24912386
doi: 10.1038/nrgastro.2014.66
Averianova, L. A., Balabanova, L. A., Son, O. M., Podvolotskaya, A. B. & Tekutyeva, L. A. Production of vitamin B2 (riboflavin) by microorganisms: an overview. Front. Bioeng. Biotechnol. https://doi.org/10.3389/fbioe.2020.570828 (2020).
Guo, Q., Goldenberg, J. Z., Humphrey, C., El Dib, R. & Johnston, B. C. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst. Rev. https://doi.org/10.1002/14651858.cd004827.pub5 (2019).
Parma, M., Stella Vanni, V., Bertini, M. & Candiani, M. Probiotics in the prevention of recurrences of bacterial vaginosis. Alter. Ther. Health Med. 20, 52–57 (2014).
Zhao, Y., Dong, B. R. & Hao, Q. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst. Rev. https://doi.org/10.1002/14651858.CD006895.pub4 (2022).
Johnston, B. C. et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann. Intern. Med. 157, 878–888 (2012).
pubmed: 23362517
doi: 10.7326/0003-4819-157-12-201212180-00563
Abad, C. L. & Safdar, N. The role of Lactobacillus probiotics in the treatment or prevention of urogenital infections—a systematic review. J. Chemother. 21, 243–252 (2009).
pubmed: 19567343
doi: 10.1179/joc.2009.21.3.243
Sharif, S., Meader, N., Oddie, S. J., Rojas-Reyes, M. X. & McGuire, W. Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants. Cochrane Database Syst. Rev. https://doi.org/10.1002/14651858.CD005496.pub5 (2020).
He, Y. et al. Evaluation of the inhibitory effects of lactobacillus gasseri and lactobacillus crispatus on the adhesion of seven common lower genital tract infection-causing pathogens to vaginal epithelial cells. Front. Med. 7, 284 (2020).
Menendez, A. et al. Bacterial stimulation of the TLR-MyD88 pathway modulates the homeostatic expression of ileal paneth cell α-defensins. J. Innate Immun. 5, 39–49 (2013).
pubmed: 22986642
doi: 10.1159/000341630
Hao, H. et al. Effect of extracellular vesicles derived from Lactobacillus plantarum Q7 on gut microbiota and ulcerative colitis in mice. Front. Immunol. 12, 777147 (2021).
Happel, A. U. et al. Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis. PLoS Pathog. 16, e1008559 (2020).
Lebeer, S., Vanderleyden, J. & De Keersmaecker, S. C. J. Genes and molecules of lactobacilli supporting probiotic action. Microbiol. Mol. Biol. Rev. 72, 728–764 (2008).
pubmed: 19052326
pmcid: 2593565
doi: 10.1128/MMBR.00017-08
Hernández-Alcántara, A. M. et al. The Ability of Riboflavin-Overproducing Lactiplantibacillus plantarum Strains to Survive Under Gastrointestinal Conditions. Front. Microbiol. 11, 591945 (2020).
Mohedano, M. L. et al. Real-time detection of riboflavin production by Lactobacillus plantarum strains and tracking of their gastrointestinal survival and functionality in vitro and in vivo using mCherry labeling. Front. Microbiol. 10, 1748 (2019).
Yépez, A. et al. In situ riboflavin fortification of different kefir-like cereal-based beverages using selected Andean LAB strains. Food Microbiol. 77, 61–68 (2019).
Kim, J. Y. et al. Probiotic potential of a novel vitamin B2-overproducing lactobacillus Plantarum strain, HY7715, isolated from Kimchi. Appl. Sci. 11, 5765 (2021).
Thakur, K. & Tomar, S. K. Exploring indigenous Lactobacillus species from diverse niches for riboflavin production. J. Young Pharm. 7, 126–131 (2015).
doi: 10.5530/jyp.2015.2.11
Burgess, C. M., Smid, E. J., Rutten, G. & van Sinderen, D. A general method for selection of riboflavin-overproducing food grade micro-organisms. Microb. Cell Fact 5, 24 (2006).
Ripa, I. et al. A single change in the aptamer of the Lactiplantibacillus plantarum rib operon riboswitch severely impairs its regulatory activity and leads to a vitamin B2- overproducing phenotype. Micro. Biotechnol. 15, 1253–1269 (2022).
doi: 10.1111/1751-7915.13919
Subramanian, V. S. et al. Differential expression of human riboflavin transporters -1, -2, and -3 in polarized epithelia: a key role for hRFT-2 in intestinal riboflavin uptake. Biochim. Biophys. Acta Biomembr. 1808, 3016–3021 (2011).
doi: 10.1016/j.bbamem.2011.08.004
Nel, I., Bertrand, L., Toubal, A. & Lehuen, A. MAIT cells, guardians of skin and mucosa? Mucosal Immunol. 14, 803–814 (2021).
Hinks, T. S. C. et al. Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality. Cell Rep. 28, 3249–3262.e5 (2019).
Wang, H. et al. MAIT cells protect against pulmonary Legionella longbeachae infection. Nat. Commun. 9, 3350 (2018).
Vorkas, C. K. et al. Mucosal-associated invariant and γδ T cell subsets respond to initial Mycobacterium tuberculosis infection. JCI Insight 3, e121899 (2018).
Oh, S. F., Jung, D.-J. & Choi, E. Gut microbiota-derived unconventional T cell ligands: contribution to host immune modulation. Immunohorizons 6, 476–487 (2022).
pubmed: 35868838
doi: 10.4049/immunohorizons.2200006
Van Wilgenburg, B. et al. MAIT cells are activated during human viral infections. Nat. Commun. 7, 11653 (2016).
Jouan, Y. et al. Phenotypical and functional alteration of unconventional T cells in severe COVID-19 patients. J. Exp. Med. 217, e20200872 (2020).
Parrot, T. et al. MAIT cell activation and dynamics associated with COVID-19 disease severity. Sci. Immunol. 5, eabe1670 (2020).
Kuri-Cervantes, L. et al. Comprehensive mapping of immune perturbations associated with severe COVID-19. Sci. Immunol. 5, eabd7114 (2020).
Flament, H. et al. Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity. Nat. Immunol. 22, 322–335 (2021).
pubmed: 33531712
doi: 10.1038/s41590-021-00870-z
Godfrey, D. I., Koay, H. F. & McCluskey, J. The biology and functional importance of MAIT cells. Nat. Immunol. 20, 1110–1128 (2019).
pubmed: 31406380
doi: 10.1038/s41590-019-0444-8
Klenerman, P., Hinks, T. S. C. & Ussher, J. E. Biological functions of MAIT cells in tissues. Mol. Immunol. 130, 154–158 (2021).
pubmed: 33358567
doi: 10.1016/j.molimm.2020.12.017
du Halgouet, A. et al. Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing. Immunity 56, 78–92.e6 (2023).
pubmed: 36630919
pmcid: 9839364
doi: 10.1016/j.immuni.2022.12.004
Constantinides, M. G. et al. MAIT cells are imprinted by the microbiota in early life and promote tissue repair. Science 366, eaax6624 (2019).
Legoux, F. et al. Microbial metabolites control the thymic development of mucosal-associated invariant T cells. Science 366, 494–499 (2019).
Ciobanu, L. et al. Effect of Lactobacillus plantarum ACTT 8014 on 5-fluorouracil induced intestinal mucositis in Wistar rats. Exp. Ther. Med. 20, 1–1 (2020).
doi: 10.3892/etm.2020.9339
Levit, R., Savoy de Giori, G., de Moreno de LeBlanc, A. & LeBlanc, J. G. Protective effect of the riboflavin-overproducing strain Lactobacillus plantarum CRL2130 on intestinal mucositis in mice. Nutrition 54, 165–172 (2018).
pubmed: 29982144
doi: 10.1016/j.nut.2018.03.056
Perez Visñuk, D. et al. Neuroprotective effect of riboflavin producing lactic acid bacteria in parkinsonian models. Neurochem. Res. 47, 1269–1279 (2022).
pubmed: 35113305
doi: 10.1007/s11064-021-03520-w
Hardy, A. et al. Guidance on the assessment of the biological relevance of data in scientific assessments. EFSA J. 15, e04970 (2017).
Sharma, V. et al. B-vitamin sharing promotes stability of gut microbial communities. Front. Microbiol. 10, 1485 (2019).
Soto-Martin, E. C. et al. Vitamin biosynthesis by human gut butyrate-producing bacteria and cross-feeding in synthetic microbial communities. mBio. 11, 1–18 (2020).
doi: 10.1128/mBio.00886-20
Buckel, W. & Thauer, R. K. Flavin-based electron bifurcation, a new mechanism of biological energy coupling. Chem. Rev. 118, 3862–3886 (2018).
pubmed: 29561602
doi: 10.1021/acs.chemrev.7b00707
Tejedor-Sanz, S. et al. Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism. Elife 11, e70684 (2022).
Wang, W. et al. Bacterial extracellular electron transfer occurs in mammalian gut. Anal. Chem. 91, 12138–12141 (2019).
pubmed: 31512863
doi: 10.1021/acs.analchem.9b03176
Oña, L. & Kost, C. Cooperation increases robustness to ecological disturbance in microbial cross-feeding networks. Ecol. Lett. 25, 1410–1420 (2022).
pubmed: 35384221
doi: 10.1111/ele.14006
Canon, F., Nidelet, T., Guédon, E., Thierry, A. & Gagnaire, V. Understanding the mechanisms of positive microbial interactions that benefit lactic acid bacteria co-cultures. Front. Microbiol. 11, 1–16 (2020).
doi: 10.3389/fmicb.2020.02088
Fassarella, M. et al. Gut microbiome stability and resilience: elucidating the response to perturbations in order to modulate gut health. Gut 70, 595–605 (2021).
pubmed: 33051190
doi: 10.1136/gutjnl-2020-321747
Bourgonje, A. R. Microbial riboflavin biosynthesis associates with response to dietary fiber consumption: time to personalize adjunct therapy in patients with inflammatory bowel disease? Gastroenterology 165, 515–516 (2023).
Haggarty, P. et al. Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet 367, 1513–1519 (2006).