Longitudinal liquid biopsy predicts clinical benefit from immunotherapy in advanced non-small cell lung cancer.


Journal

NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166

Informations de publication

Date de publication:
17 Oct 2024
Historique:
received: 09 01 2024
accepted: 11 09 2024
medline: 18 10 2024
pubmed: 18 10 2024
entrez: 17 10 2024
Statut: epublish

Résumé

High heterogeneity in clinical benefit characterizes the use of immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC). We prospectively enrolled 113 advanced NSCLC patients treated with ICIs and performed liquid biopsy at the time of ICI start (T1), after 3 weeks (T2) and at the time of radiological evaluation (T3). Molecular variables were associated with outcome endpoints: cfDNA quantification, its dynamic change (∆T2-T1), variant allele frequency (VAF) of the gene with the highest frequency detected at baseline with NGS (maxVAF) and its dynamic change (∆T2-T1). At multivariate analysis, PD-L1 negativity, T1 cfDNA, cfDNA increase (∆T2-T1), and T2 VAF were significantly associated with shorter progression-free survival (PFS); PD-L1 negativity, squamous histology, T1 cfDNA, cfDNA (∆T2-T1) increase, and T2 maxVAF affected overall survival (OS). Among high PD-L1 expressing patients treated in first-line, elevated T2 maxVAF and cfDNA increase (∆T2-T1) correlated with worse PFS; higher T2 maxVAF and cfDNA increase (∆T2-T1) with worse OS. Derived integrated models were used to build nomograms and categorize different risk groups.

Identifiants

pubmed: 39420036
doi: 10.1038/s41698-024-00704-9
pii: 10.1038/s41698-024-00704-9
doi:

Types de publication

Journal Article

Langues

eng

Pagination

234

Informations de copyright

© 2024. The Author(s).

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Auteurs

Andrea Boscolo Bragadin (A)

Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Paola Del Bianco (P)

Clinical Research Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Elisabetta Zulato (E)

Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Ilaria Attili (I)

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Alberto Pavan (A)

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Jessica Carlet (J)

Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Ludovica Marra (L)

Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Valentina Guarneri (V)

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Stefano Indraccolo (S)

Basic and Translational Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.

Laura Bonanno (L)

Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy. laura.bonanno@unipd.it.
Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. laura.bonanno@unipd.it.

Classifications MeSH