In Situ Expression of TNF-α and IL-10 in Human Dermatophytosis Lesions due to Trichophyton rubrum.
T. rubrum
Dermatophytosis
IL-10
Immune response
TNF-α
Journal
Mycopathologia
ISSN: 1573-0832
Titre abrégé: Mycopathologia
Pays: Netherlands
ID NLM: 7505689
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
14
09
2023
accepted:
13
09
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
17
10
2024
Statut:
epublish
Résumé
Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-α and IL-10 in human dermatophytosis. Expression of TNF-α and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-α and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response.
Identifiants
pubmed: 39420083
doi: 10.1007/s11046-024-00895-6
pii: 10.1007/s11046-024-00895-6
doi:
Substances chimiques
Interleukin-10
130068-27-8
Tumor Necrosis Factor-alpha
0
IL10 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2018/16146-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2018/24175-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2017/26208-8
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2016/16369-1
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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