The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system of
C. elegans
GABA
developmental biology
excitation/inhibition balance
ketone bodies
neurodevelopment
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
18
10
2024
Statut:
epublish
Résumé
A finely tuned balance between excitation and inhibition (E/I) is essential for proper brain function. Disruptions in the GABAergic system, which alter this equilibrium, are a common feature in various types of neurological disorders, including autism spectrum disorders (ASDs). Mutations in To work optimally, the brain needs to delicately balance excitation and inhibition – that is, it must precisely control exactly when and how excitatory neurons (which activate the system) or inhibitory ones (which counteract these activating signals) are switched on. Neurological disorders can arise when this equilibrium is disrupted, for example when defects are present in an inhibitory signalling system that relies on a molecule known as GABA. More recently, a gene known as
Autres résumés
Type: plain-language-summary
(eng)
To work optimally, the brain needs to delicately balance excitation and inhibition – that is, it must precisely control exactly when and how excitatory neurons (which activate the system) or inhibitory ones (which counteract these activating signals) are switched on. Neurological disorders can arise when this equilibrium is disrupted, for example when defects are present in an inhibitory signalling system that relies on a molecule known as GABA. More recently, a gene known as
Identifiants
pubmed: 39422188
doi: 10.7554/eLife.94520
pii: 94520
doi:
pii:
Substances chimiques
Caenorhabditis elegans Proteins
0
PTEN Phosphohydrolase
EC 3.1.3.67
3-Hydroxybutyric Acid
TZP1275679
DAF-18 protein, C elegans
0
Forkhead Transcription Factors
0
daf-16 protein, C elegans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : PUE- N22920170100017CO
Organisme : Consejo Nacional de Investigaciones Científicas y Técnicas
ID : PIP No. 11220200101606CO
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT 2019-0480
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT-2021-I-A-00052
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT-2017-0566
Organisme : Agencia Nacional de Promoción Científica y Tecnológica
ID : PICT-2020-1734
Organisme : Universidad Nacional del Sur
ID : PGI: 24/B291
Organisme : Universidad Nacional del Sur
ID : PGI: 24/B261
Informations de copyright
© 2024, Giunti et al.
Déclaration de conflit d'intérêts
SG, MB, MD, DR No competing interests declared