Exploring the potential therapeutic benefits of 7-methoxy coumarin for neuropathy pain: an in vivo, in vitro, and in silico approach.
7-methoxycoumarin
Gene expression
Molecular docking
Peripheral neuropathic pain
Voltage-gated calcium channel subunit alpha-2/delta-1
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
04
07
2024
accepted:
06
10
2024
medline:
18
10
2024
pubmed:
18
10
2024
entrez:
18
10
2024
Statut:
epublish
Résumé
7-Methoxycoumarin (7-MC) is well recognized for its anti-inflammatory and anti-nociceptive actions. Its capacity to lessen neuropathic pain hasn't been documented yet. Hence the impact of 7-MC on vincristine-induced peripheral neuropathic pain in rodents was investigated. The investigation also looked at the impact of 7-MC in reducing neuropathic pain via voltage-gated calcium channels and phospholipase enzyme inhibition using pertinent in vitro and in silico methods. Vincristine (0.1 mg/kg, i.p., daily) was administered continuously for 7 days to induce peripheral neuropathic pain in mice, with cold allodynia and thermal hyperalgesia and evaluated on the 8th day using the acetone bubble test and hot water tail immersion test. In order to derive the mechanistic approach for ameliorating neuropathic pain, the role of 7-MC in the inhibition of the phospholipase enzyme, gene expression studies on voltage-gated calcium channels using mouse BV2 microglial cells and in silico studies for its calcium channel binding affinity were also performed. The test compounds reduced vincristine-induced cold allodynia and thermal hyperalgesia in mice in a dose-dependent experiments. In vitro studies on phospholipase inhibition by 7-MC showed an IC The compound 7-MC has shown promise in alleviating vincristine-induced peripheral neuropathicin mice. Studies conducted in parallel, both in silico and in vitro have demonstrated that 7-MC effectively reduces neuropathic pain. This pain reduction is achieved through two mechanisms: inhibiting the phospholipase enzyme and blocking voltage-gated calcium channels.
Identifiants
pubmed: 39422771
doi: 10.1007/s11033-024-09991-8
pii: 10.1007/s11033-024-09991-8
doi:
Substances chimiques
Coumarins
0
Vincristine
5J49Q6B70F
Analgesics
0
Calcium Channels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1066Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
Références
IASP (2020) IASP Announces Revised Definition of Pain - International Association for the Study of Pain (IASP). https://www.iasp-pain.org/wp-content/uploads/2022/04/revised-definition-flysheet_R2-1-1-1.pdf
Murnion BP (2018) Neuropathic pain: current definition and review of drug treatment. Aust Prescr 41(3):61–63. https://doi.org/10.18773/austprescr.2018.022
doi: 10.18773/austprescr.2018.022
Trivedi S, Pandit A, Ganguly G, Das S (2017) Epidemiology of peripheral neuropathy: an Indian perspective. Ann Indian Acad Neurol 20(3):173–184. https://doi.org/10.4103/aian.AIAN_470_16
doi: 10.4103/aian.AIAN_470_16
pubmed: 28904445
pmcid: 5586108
Patel S, Gururani R, Smita J, Paliwal V et al (2024) Therapeutic efficacy of Digoxin in Oxaliplatin and Chronic Constriction Injury Model of Neuropathic Pain in rats. J Biol Regul Homeost Agents 38:5343–5357. https://doi.org/10.23812/j.biol.regul.homeost.agents.20243806.427
doi: 10.23812/j.biol.regul.homeost.agents.20243806.427
Albin B, Adhikari P, Tiwari AP, Qubbaj K, Yang IH (2024) Electrical stimulation enhances mitochondrial trafficking as a neuroprotective mechanism against chemotherapy-induced peripheral neuropathy. iScience. 30;27(3):109052. https://doi.org/10.1016/j.isci.2024.109052
Lolignier S, Eijkelkamp N, Wood JN (2015) Mechanical allodynia. Pflugers Arch 467(1):133–139. https://doi.org/10.1007/s00424-014-1532-0
doi: 10.1007/s00424-014-1532-0
pubmed: 24846747
Waxman SG, Zamponi GW (2014) Regulating excitability of peripheral afferents: emerging ion channel targets. Nat Neurosci 17(2):153–163. https://doi.org/10.1038/nn.3602
doi: 10.1038/nn.3602
pubmed: 24473263
Kartha S, Ghimire P, Winkelstein BA (2021) Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling. Mol Pain 17:1–15. https://doi.org/10.1177/17448069211066221
doi: 10.1177/17448069211066221
Kartha S, Yan L, Ita ME, Amirshaghaghi A et al (2020) Phospholipase A2 inhibitor-loaded Phospholipid Micelles Abolish Neuropathic Pain. ACS Nano 14(7):8103–8115. https://doi.org/10.1021/acsnano.0c00999
doi: 10.1021/acsnano.0c00999
pubmed: 32484651
pmcid: 7438274
Cruccu G (2007) Treatment of painful neuropathy. Curr Opin Neurol 20(5):531–535. https://doi.org/10.1097/WCO.0b013e328285dfd6
doi: 10.1097/WCO.0b013e328285dfd6
pubmed: 17885440
Petroianu GA, Aloum L, Adem A (2023) Neuropathic pain: mechanisms and therapeutic strategies. Front Cell Dev Biol 11:1072629. https://doi.org/10.3389/fcell.2023.107262
doi: 10.3389/fcell.2023.107262
pubmed: 36727110
pmcid: 9884983
Fornasari D (2017) Pharmacotherapy for Neuropathic Pain: a review. Pain Ther 6(1):25–33. https://doi.org/10.1007/s40122-017-0091-4
doi: 10.1007/s40122-017-0091-4
pubmed: 29178034
pmcid: 5701897
Forouzanfar F, Hosseinzadeh H (2018) Medicinal herbs in the treatment of neuropathic pain: a review. Iran J Basic Med Sci Apr 21(4):347–358. https://doi.org/10.22038/IJBMS.2018.24026.6021
doi: 10.22038/IJBMS.2018.24026.6021
Hu N, Liu J, Luo Y, Li Y (2024) A comprehensive review of traditional Chinese medicine in treating neuropathic pain. Heliyon. 3;10(17):e37350. https://doi.org/10.1016/j.heliyon.2024.e37350
Uddin MS, Al Mamun A, Rahman MA, Kabir MT, Alkahtani S, Alanazi IS, Perveen A, Ashraf GM, Bin-Jumah MN, Abdel-Daim MM (2020) Exploring the promise of flavonoids to combat neuropathic pain: from molecular mechanisms to therapeutic implications. Front Neurosci 14:4781–4716. https://doi.org/10.3389/fnins.2020.00478
doi: 10.3389/fnins.2020.00478
Pereira TM, Franco DP, Vitorio F, Kummerle AE (2018) Coumarin compounds in Medicinal Chemistry: some important examples from the last years. Curr Top Med Chem 18(2):124–148. https://doi.org/10.2174/1568026618666180329115523
doi: 10.2174/1568026618666180329115523
pubmed: 29595110
Zang Y (2020) Pharmacological activities of Coumarin compounds in Licorice: a review. Nat Prod Commun 15(9). https://doi.org/10.1177/1934578X20953954
Li R, Zhao C, Yao M, Song Y, Wu Y, Wen A (2017) Analgesic effect of coumarins from Radix Angelicae Pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain. J Ethnopharmacol 195:81–88. https://doi.org/10.1016/j.jep.2016.11.046
doi: 10.1016/j.jep.2016.11.046
pubmed: 27915078
Ghosh R, Singha PS, Das LK, Ghosh D (2023) Anti-inflammatory activity of natural coumarin compounds from plants of the Indo-Gangetic plain. AIMS Mol Sci 10(2):79–98. https://doi.org/10.3934/molsci.2023007
doi: 10.3934/molsci.2023007
Abdelaziz E, El-Deeb NM, Zayed MF, Hasanein AM, El Sayed ET, Elmongy EI, Kamoun EA (2023) Synthesis and in-vitro anti-proliferative with antimicrobial activity of new coumarin containing heterocycles hybrids. Sci Rep 13(1):22791. https://doi.org/10.1038/s41598-023-50170-9
doi: 10.1038/s41598-023-50170-9
pubmed: 38123695
pmcid: 10733349
Suja G, Vinoth Kumar T, Suganya P (2019) Evaluation of phytochemicals and in vitro anticancer activity of Eupatorium triplinerve. Int J Sci Res Biol Sci 6(5):15–18. https://doi.org/10.26438/ijsrbs/v6i5.1518
doi: 10.26438/ijsrbs/v6i5.1518
Li R, Dang S, Yao M, Zhao C, Zhang W, Cui J, Wang J, Wen A (2020) Osthole alleviates neuropathic pain in mice by inhibiting the P2Y1-receptor-dependent JNK signaling pathway. Aging 12(9):7945–7962. https://doi.org/10.18632/aging.103114
doi: 10.18632/aging.103114
pubmed: 32365053
pmcid: 7244062
Usman M, Malik H, Tokhi A, Arif M, Huma Z, Rauf K, Sewell RDE (2023) 5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines. Front Pharmacol 14:1213763. https://doi.org/10.3389/fphar.2023.1213763
doi: 10.3389/fphar.2023.1213763
pubmed: 37920212
pmcid: 10619918
Chaurasiya ND, Leon F, Muhammad I, Tekwani BL (2022) Natural products inhibitors of monoamine oxidases—potential new drug leads for neuroprotection, neurological disorders, and neuroblastoma. Molecules 27(13):4297. https://doi.org/10.3390/molecules27134297
doi: 10.3390/molecules27134297
pubmed: 35807542
pmcid: 9268457
Keri RS, Budagumpi S, Somappa SB (2022) Synthetic and natural coumarins as potent anticonvulsant agents: a review with structure–activity relationship. J Clin Pharm Ther 47(7):915–931. https://doi.org/10.1111/jcpt.13644
doi: 10.1111/jcpt.13644
pubmed: 35288962
Cheriyan BV, Kadhirvelu P, Nadipelly J, Shanmugasundaram J, Sayeli V, Subramanian V (2017) Anti-nociceptive effect of 7-methoxy coumarin from Eupatorium Triplinerve vahl (Asteraceae). Pharmacogn Mag 13(49):81–84. https://doi.org/10.4103/0973-1296.197650
doi: 10.4103/0973-1296.197650
pubmed: 28216887
pmcid: 5307919
Katsuyama S, Aso H, Otowa A, Yagi T et al (2014) Antinociceptive Effects of the Serotonin and Noradrenaline Reuptake Inhibitors Milnacipran and Duloxetine on Vincristine-Induced Neuropathic Pain Model in Mice. ISRN Pain. 2014:915464,1–7 https://doi.org/10.1155/2014/915464
Waszkielewicz AM, Gunia A, Sloczynska K, Marona H (2011) Evaluation of anticonvulsants for possible use in neuropathic pain. Cur Med Chem 18(28):4344–4358. https://doi.org/10.2174/092986711797200408
doi: 10.2174/092986711797200408
Vasudevan R, Batool S, Kandasamy G, Saeed SF, Saleh N, Mohammed M, Awad AG (2019) Anti-nociceptive effect of gabapentin in mouse models of acute and chronic painTrop. J Pharm 18(7):1475–1480. https://doi.org/10.4314/tjpr.v18i7.16
doi: 10.4314/tjpr.v18i7.16
Flatters SJL, Bennett GJ (2004) Ethosuximide reverses paclitaxel- and vincristine-induced painful peripheral neuropathy. Pain 109(1–2):150–161. https://doi.org/10.1016/j.pain.2004.01.029
doi: 10.1016/j.pain.2004.01.029
pubmed: 15082137
Shanmugasundaram JNadipelly JS, Kathirvelu P, Revathi K, Vijayakumar S, Subramanian VManoharan R (2020) Ameliorative effect of 5-methoxyflavone on vincristine induced peripheral neuropathy in mice. Ann Rom Soc Cell Biol 24(1):364–370. http://annalsofrscb.ro/index.php/journal/article/view/9673
Lauren TE, Low PA, Windebank AJ (2009) Mice with cisplatin and oxaliplatin-induced painful neuropathy develop distinct early responses to thermal stimuli. Mol Pain 5(9):1–9. https://doi.org/10.1186/1744-8069-5-9
doi: 10.1186/1744-8069-5-9
Kammoun M, Miladi S, Ali YB, Damak M, Gargouri Y, Bezzine S (2011) In vitro study of the PLA2 inhibition and antioxidant activities of Aloe vera leaf skin extracts. Lipids Health Dis 10:301–307. https://doi.org/10.1186/1476-511X-10-30
doi: 10.1186/1476-511X-10-30
Jin CY, Lee JD, Park C, Choi YH, Kim GY (2007) Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacol Sin 28(10):1645–1651. https://doi.org/10.1111/j.1745-7254.2007.00651.x
doi: 10.1111/j.1745-7254.2007.00651.x
pubmed: 17883952
Saddala MS, Lennikov A, Mukwaya A, Yanf Y, Hill MA, Lagali N, Huang H (2020) Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis. J Neuroinflammation 17(1):132. https://doi.org/10.1186/s12974-020-01801-9
doi: 10.1186/s12974-020-01801-9
pubmed: 32334630
pmcid: 7183139
Gee NS, Brown JP, Dissanayake VU, Offord J, Thurlow R, Woodruff GN (1996) The novel anticonvulsant drug, gabapentin (neurontin), binds to the α2δ subunit of a calcium channel. J Biol Chem 271(10):5768–5776. https://doi.org/10.1074/jbc.271.10.5768
doi: 10.1074/jbc.271.10.5768
pubmed: 8621444
Sayers EW, Bolton EE, Brister JR, Canese K, Chan J, Comeau DC, Connor R, Funk K, Kelly C, Sunghwan K, Madej T, Marchler-Bauer A, Lanczycki C, Lathrop S, Lu Z, Thibaud-Nissen F, Murphy T, Phan L, Skripchenko Y, Tse T, Wang J, Williams R, Trawkick BW, Pruitt KD, Sherry ST (2022) Database resources of the national center for biotechnology information. Nucleic Acids Res 50(D1):D20-D-26. https://doi.org/10.1093/nar/gkab1112
Duhovny D, Nussinov R, Wolfson HJ (2002) Efficient unbound docking of rigid molecules. In: Guigó R, Gusfield D (eds) Algorithms in Bioinformatics. WABI 2002. Lecture Notes in Computer Science, vol 2452. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45784-4_14
doi: 10.1007/3-540-45784-4_14
Schneidman-Duhovny D, Inbar Y, Nussinov R, Wolfson H (2005) PatchDock and SymmDock: servers for rigid and symmetric docking. Nucleic Acids Res 33(Web Server Issue):W363-367. https://doi.org/10.1093/nar/gki481
doi: 10.1093/nar/gki481
pubmed: 15980490
pmcid: 1160241
Park SH, Sim YB, Kang YJ, Kim SS et al (2013) Antinociceptive profiles and mechanisms of orally administered coumarin in mice. Biol Pharm Bull 36(6):925–930. https://doi.org/10.1248/bpb.b12-00905
doi: 10.1248/bpb.b12-00905
pubmed: 23727914
Cavaletti G, Marmiroli P (2015) Chemotherapy-induced peripheral neurotoxicity. Curr Opin Neurol 28(5):500–507. https://doi.org/10.1097/WCO.0000000000000234
doi: 10.1097/WCO.0000000000000234
pubmed: 26197027
Scripture CD, Figg WD, Sparreboom A (2006) Peripheral neuropathy induced by paclitaxel: recent insights and future perspectives. Curr Neuropharmacol 4(2):165–172. https://doi.org/10.2174/157015906776359568
doi: 10.2174/157015906776359568
pubmed: 18615126
pmcid: 2430667
Goyal SN, Reddy NM, Patil KR, Nakhate KT et al (2016) Challenges and issues with streptozotocin-induced diabetes – a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics. ChemBiol Interact 244:49–63. https://doi.org/10.1016/j.cbi.2015.11.032
doi: 10.1016/j.cbi.2015.11.032
Colleoni M, Sacerdote P (2010) Murine models of human neuropathic pain Biochim Biophys Acta. 1802(10):924–933. https://doi.org/10.1016/j.bbadis.2009.10.012
Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F (2003) An animal model of vincristine-induced nociceptive peripheral neuropathy. Neurotoxicology 24(6):797–805. https://doi.org/10.1016/s0161-813x(03)00043-3
doi: 10.1016/s0161-813x(03)00043-3
pubmed: 14637374
Aley KO, Reichling DB JD (1996) Levine,Vincristine hyperalgesia in the rat: a model of painful vincristine neuropathy in humans. Neuroscience 73(1):259–265. https://doi.org/10.1016/0306-4522(96)00020-6
Authier N, Gillet JP, Fialip J, Eschalier A, Coudore F (2003) An animal model of peripheral neuropathy induced by repeated administration of vincristine. Pain 104(1–2):203–212
Usman M, Malik H, Ahmed Z, Tokhi A, Arif, Mehreen, Huma, Zilli, Rauf, Khalid, Sewell R (2023) 6,7,8-Trimethoxycoumarin attenuates vincristine induced peripheral neuropathic pain, potential role of 5HT3 and opioid receptors and monoamines. Journal of Xi’an Shiyou University, Natural Science Edition 19(6):425–464. http://xisdxjxsu.asia
Coudoré F, Chemaly N, Balayssac D, Ravaux P, André V, Delpierre S (2013) Behavioral assessment of vincristine-induced neuropathy and effects of duloxetine and gabapentin in rats. Neuroscience 231:129–139
Muthuraman A, Singh N (2011) Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats. J Nat Med 65(3–4):480–487. https://doi.org/10.1007/s11418-011-0525-y
doi: 10.1007/s11418-011-0525-y
pubmed: 21404093
Greeshma N, Prasanth KG, Balaji B (2015) Tetrahydrocurcumin exerts protective effect on vincristine induced neuropathy: behavioral, biochemical, neurophysiological and histological evidence. Chem Biol Interact 238:118–128. https://doi.org/10.1016/j.cbi.2015.06.025
doi: 10.1016/j.cbi.2015.06.025
pubmed: 26102012
Sommer C, Leinders M, Üçeyler N (2017) Inflammation in the pathophysiology of neuropathic pain. Pain 159(3):595–602. https://doi.org/10.1097/j.pain.0000000000001122
doi: 10.1097/j.pain.0000000000001122
Xie H, Chen Y, Du K, Wu W, Feng X (2020) Puerarin alleviates vincristine-induced neuropathic pain and neuroinflammation via inhibition of nuclear factor-κB and activation of the TGF-β/Smad pathway in rats. Int Immunopharmacol 89pt B:107060. https://doi.org/10.1016/j.intimp.2020.107060
doi: 10.1016/j.intimp.2020.107060
Chinnasamy S, Selvaraj G, Selvaraj C, Kaushik AC et al (2020) Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2). Int J Biol Macromol 1144:53–66. https://doi.org/10.1016/j.ijbiomac.2019.12.091
doi: 10.1016/j.ijbiomac.2019.12.091
Titsworth WL, Cheng X, Ke Y, Deng L, Burckardt KA, Pendleton C, Liu NK, Shao H, Cao QL, Xu XM (2009) Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. Glia 57(14):1521–1537. https://doi.org/10.1002/glia.20867
doi: 10.1002/glia.20867
pubmed: 19306380
pmcid: 4461868
Chacur M, Milligan ED, Sloan EM, Wieseler-Frank J et al (2004) Snake venom phospholipase A2s (Asp49 and Lys49) induce mechanical allodynia upon peri-sciatic administration: involvement of spinal cord glia, proinflammatory cytokines and nitric oxide. Pain 108(1–2):180–191. https://doi.org/10.1016/j.pain.2003.12.023
doi: 10.1016/j.pain.2003.12.023
pubmed: 15109522
Quan L, Uyeda A, Muramatsu R (2022) Central nervous system regeneration: the roles of glial cells in the potential molecular mechanism underlying remyelination. Inflamm Regen 42(7):1–12. https://doi.org/10.1186/s41232-022-00193-y
doi: 10.1186/s41232-022-00193-y
La Torre ME, Cianciulli A, Monda V (2023) α-Tocopherol Protects Lipopolysaccharide-Activated BV2 Microglia. Molecules 10;28(8):3340. https://doi.org/10.3390/molecules28083340
Calvo M, Bennett DL (2012) The mechanisms of microgliosis and pain following peripheral nerve injury. Exp Neurol 234(2):271–282. https://doi.org/10.1016/j.expneurol.2011.08.018
doi: 10.1016/j.expneurol.2011.08.018
pubmed: 21893056
Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 2 40(2):133–139. https://doi.org/10.1002/glia.10154
doi: 10.1002/glia.10154
Suter MR, Wen YR, Decosterd I, Ji RR (2007) Do glial cells control pain? Neuron Glia Biol 3(3):255–268. https://doi.org/10.1017/S1740925X08000100
doi: 10.1017/S1740925X08000100
pubmed: 18504511
pmcid: 2394739
Ji RR, Suter MR (2007) p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain 3:331–339. https://doi.org/10.1186/1744-8069-3-33
doi: 10.1186/1744-8069-3-33
Von Hehn CA, Baron R, Woolf CJ (2012) Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron 73(4):638–652. https://doi.org/10.1016/j.neuron.2012.02.008
doi: 10.1016/j.neuron.2012.02.008
Clark AK, Staniland AA, Marchand F, Kaan TKY, McMahon SB, Malcangio M (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30(2):573–582. https://doi.org/10.1523/JNEUROSCI.3295-09.2010
doi: 10.1523/JNEUROSCI.3295-09.2010
pubmed: 20071520
pmcid: 2880485
Wen YR, Tan PH, Cheng JK, Liu YC, Ji RR (2011) Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc 110(8):487–494. https://doi.org/10.1016/S0929-6646(11)60074-0
doi: 10.1016/S0929-6646(11)60074-0
pubmed: 21783017
pmcid: 3169792
Echeverry S, Shi XQ, Zhang J (2008) Characterization of cell proliferation in rat spinal cord following peripheral nerve injury and the relationship with neuropathic pain. Pain 135(1–2):37–47. https://doi.org/10.1016/j.pain.2007.05.002
doi: 10.1016/j.pain.2007.05.002
pubmed: 17560721
Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87(2):149–158. https://doi.org/10.1016/s0304-3959(00)00276-1
doi: 10.1016/s0304-3959(00)00276-1
pubmed: 10924808
Li GZ, Hu YH, Li DY, Zhang Y, Guo HL, Li YM, Chen F, Xu J (2020) Vincristine-induced peripheral neuropathy: a mini-review. Neurotoxicology 81:161–171. https://doi.org/10.1016/j.neuro.2020.10.004
doi: 10.1016/j.neuro.2020.10.004
pubmed: 33053366
Sharma J, Maslov LN, Singh N, Jaggi AS (2020) Pain attenuating actions of vincristine preconditioning in chemotherapeutic agent-induced neuropathic pain: key involvement of T-type calcium channels.FundamClin. Pharmacol 34(3):336–344. https://doi.org/10.1111/fcp.12519
doi: 10.1111/fcp.12519
Jarvis MS, Scott VE, McGaraughty S, Chu KL, Xu J, Niforatos W, Milicic I, Joshi S, Zhang Q, Xia Z (2014) A peripherally acting, selective T-type calcium channel blocker, ABT-639, effectively reduces nociceptive and neuropathic pain in rats. Biochem Pharmacol 89(4):536–544. https://doi.org/10.1016/j.bcp.2014.03.015
doi: 10.1016/j.bcp.2014.03.015
pubmed: 24726441
Muthuraman AAS, Jaggi NS, Singh N, Singh D (2008) Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats. Eur J Pharmacol 587(1–3):104–111. https://doi.org/10.1016/j.ejphar.2008.03.042
doi: 10.1016/j.ejphar.2008.03.042
pubmed: 18486127
Siau C, Bennett GJ (2006) Dysregulation of cellular calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth Analg 102(5):1485–1490. https://doi.org/10.1213/01.ane.0000204318.35194.ed
doi: 10.1213/01.ane.0000204318.35194.ed
pubmed: 16632831
pmcid: 1805480
Sulova Z, Orlicky J, Fiala R, Dovinova I, Uhrik B, Seres M, Gibalova L, Breier A (2005) Expression of P-glycoprotein in L1210 cells is linked with rise in sensitivity to Ca2+. Biochem Biophys Res Commun 335(3):777–784. https://doi.org/10.1016/j.bbrc.2005.07.144
doi: 10.1016/j.bbrc.2005.07.144
pubmed: 16098480
Qin J, Ma Z, Chen X, Shu S (2023) Microglia activation in central nervous system disorders: a review of recent mechanistic investigations and development efforts. Front Neurol 7:14:1103416. https://doi.org/10.3389/fneur.2023.1103416
doi: 10.3389/fneur.2023.1103416
Giulian D, Li J, Li X, George J, Rutecki PA (1994) The impact of Microglia-derived cytokines upon gliosis in the CNS. Dev Neurosci 16(3–4):128–136. https://doi.org/10.1159/00011209
doi: 10.1159/00011209
pubmed: 7535679
Zielasek J, Hartung HP (1996) Molecular mechanisms of microglial activation. Adv Neuroimmunol 6(2):191–222. https://doi.org/10.1016/0960-5428(96)00017-4
doi: 10.1016/0960-5428(96)00017-4
pubmed: 8876774
Luo C, Jian C, Liao Y, Huang Q, Wu Y, Liu X, Zou D, Wu Y (2017) The role of microglia in multiple sclerosis. Neuropsychiatr Dis Treat 13:1661–1667. https://doi.org/10.2147/NDT.S140634
doi: 10.2147/NDT.S140634
pubmed: 28721047
pmcid: 5499932
Navarro V, Sanchez-Mejias E, Jimenez S, Munoz-Castro C, Sanchez Varo R, Davila JC, Vizuete M, Gutierrez, Vitorica J (2018) Microglia in Alzheimer’s disease: activated, dysfunctional or degenerative. Front Aging Neurosci 10:140. https://doi.org/10.3389/fnagi.2018.00140
doi: 10.3389/fnagi.2018.00140
pubmed: 29867449
pmcid: 5958192
Stebbing MJ, Cottee JM, Rana I (2015) The role of ion channels in microglial activation and proliferation - a complex interplay between ligand-gated ion channels, K + channels, and intracellular Ca2+. Front Immunol 6:497. https://doi.org/10.3389/fimmu.2015.00497
doi: 10.3389/fimmu.2015.00497
pubmed: 26557116
pmcid: 4617059
Saegusa H, Tanabe T (2014) N-type voltage-dependent Ca2 + channel in non-excitable microglial cells in mice is involved in the pathophysiology of neuropathic pain. Biochem Biophys Res Commun 450(1):142–147. https://doi.org/10.1016/j.bbrc.2014.05.103
doi: 10.1016/j.bbrc.2014.05.103
pubmed: 24887565
Gazulla J, Tintoré M (2007) Canales De Calcio dependientes de voltaje de tipo P/Q en neurología. Neurologia 22(8):511–516
pubmed: 17573560
Prathap L, Jayaraman S, Roy A, Santhakumar P, Jeevitha M (2021) Molecular docking analysis of stachydrine and sakuranetin with IL-6 and TNF-α in the context of inflammation. Bioinformation 17(2):363–368. https://doi.org/10.6026/97320630017363
doi: 10.6026/97320630017363
pubmed: 34234397
pmcid: 8225604
Roy A (2021) Molecular docking analysis of compounds from Andrographis paniculata with EGFR. Bioinformation 17(1):23–28. https://doi.org/10.6026/97320630017023
doi: 10.6026/97320630017023
pubmed: 34393414
pmcid: 8340687
Sukumaran G, Ezhilarasan D, Ramani P, Merlin RJ (2022) Molecular docking analysis of syringic acid with proteins in inflammatory cascade. Bioinformation 18(3):219–225. https://doi.org/10.6026/97320630018219
doi: 10.6026/97320630018219
pubmed: 36518124
pmcid: 9722417