Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.

Animals Astrocytes / metabolism Homeostasis Glucose / metabolism Glucose Transporter Type 1 / metabolism Mice Brain / metabolism Energy Metabolism Insulin / metabolism Signal Transduction Adenosine Triphosphate / metabolism Mice, Knockout Obesity / metabolism Receptor, Insulin / metabolism

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
18 Oct 2024
Historique:
medline: 18 10 2024
pubmed: 18 10 2024
entrez: 18 10 2024
Statut: ppublish

Résumé

Astrocytes are considered an essential source of blood-borne glucose or its metabolites to neurons. Nonetheless, the necessity of the main astrocyte glucose transporter, i.e., GLUT1, for brain glucose metabolism has not been defined. Unexpectedly, we found that brain glucose metabolism was paradoxically augmented in mice with astrocytic GLUT1 reduction (GLUT1

Identifiants

DOI: 10.1126/sciadv.adp1115 PMID: 39423276
pubmed: 39423276
doi: 10.1126/sciadv.adp1115
doi:

Substances chimiques

Glucose IY9XDZ35W2
Glucose Transporter Type 1 0
Slc2a1 protein, mouse 0
Insulin 0
Adenosine Triphosphate 8L70Q75FXE
Receptor, Insulin EC 2.7.10.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp1115

Auteurs

Carlos G Ardanaz (CG)

Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0001-5328-2986

Aida de la Cruz (A)

Laboratory of Local Translation in Neurons and Glia, Achucarro Basque Centre for Neuroscience, 48940 Leioa, Spain.
ORCID: 0000-0002-6039-8263

Paras S Minhas (PS)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-7741-3327

Nira Hernández-Martín (N)

Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.
PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
ORCID: 0009-0009-3933-1804

Miguel Ángel Pozo (MÁ)

Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Unidad de Cartografía Cerebral, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain.
ORCID: 0000-0001-9303-0513

M Pilar Valdecantos (MP)

Instituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid 28029, Spain.
Universidad Francisco de Vitoria, Faculty of Experimental Sciences, Pozuelo de Alarcon, Madrid, Spain.
ORCID: 0000-0002-3239-4898

Ángela M Valverde (ÁM)

Instituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid 28029, Spain.
ORCID: 0000-0003-1192-9045

Palmira Villa-Valverde (P)

ICTS Bioimagen Complutense, Universidad Complutense de Madrid, Madrid, Spain.
ORCID: 0000-0001-9054-9176

Marcos Elizalde-Horcada (M)

Institut d'Investigació Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain.

Elena Puerta (E)

Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0001-5695-5787

María J Ramírez (MJ)

Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Jorge E Ortega (JE)

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Department of Pharmacology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Biobizkaia Health Research Institute, 48903 Barakaldo, Spain.
ORCID: 0000-0001-8188-874X

Ainhoa Urbiola (A)

IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain.

Cristina Ederra (C)

IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain.
ORCID: 0009-0003-9876-4657

Mikel Ariz (M)

IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain.
Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, 31006 Pamplona, Spain.
ORCID: 0000-0002-7328-1582

Carlos Ortiz-de-Solórzano (C)

IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain.
ORCID: 0000-0001-8720-0205

Joaquín Fernández-Irigoyen (J)

Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain.
ORCID: 0000-0001-5072-4099

Enrique Santamaría (E)

Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain.
ORCID: 0000-0001-8046-8102

Gerard Karsenty (G)

Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY, USA.
ORCID: 0000-0002-9253-7627

Jens C Brüning (JC)

Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, 50931 Cologne, Germany.
Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany.
Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.
National Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
ORCID: 0000-0002-6619-0092

Maite Solas (M)

Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.
IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.
ORCID: 0000-0001-7670-3237

Articles similaires

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de glucose par diffusion facilitée › Transporteur de glucose de type 1 › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › Adénosine triphosphate › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Astrocytic GLUT1 reduction paradoxically...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteur à l'insuline › Astrocytic GLUT1 reduction paradoxically...