Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: A multicentric propensity score-based analysis.

Facial nerve Parotid cancer Surgery propensity score

Journal

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
ISSN: 1532-2157
Titre abrégé: Eur J Surg Oncol
Pays: England
ID NLM: 8504356

Informations de publication

Date de publication:
10 Oct 2024
Historique:
received: 28 03 2024
revised: 01 10 2024
accepted: 04 10 2024
medline: 19 10 2024
pubmed: 19 10 2024
entrez: 18 10 2024
Statut: aheadofprint

Résumé

The management of the facial nerve (FN) is a major issue in parotid cancer, especially when there is no preoperative facial palsy and FN invasion is discovered intraoperatively. The aim of this study was to assess the impact of FN resection in patients with parotid cancer abutting the FN, without pretreatment facial palsy, using a propensity score matching. Data from all patients treated between 2009 and 2020 for a primary parotid cancer abutting or invading the FN but without pretreatment facial palsy were extracted from the national multicentric REFCOR database. Three different definitions of tumors abutting the FN were used for sensitivity analyses, in a retrospective setting. Propensity score matching was used to assess the impact of FN resection on disease-free survival (DFS), overall survival (OS) and locoregional recurrence-free survival (LRRFS). A total of 163 patients with parotid cancer abutting or invading the FN without pretreatment facial palsy were included. Among them, 99 patients (61 %) underwent FN resection. After overlap weighting and multiple imputation, no benefit of FN resection over preservation was found in terms of OS (HR = 1.21, p = 0.6), DFS (HR = 0.88, p = 0.5) and LRRFS (HR = 0.99, p = 1). Sensitivity analyses revealed similar results, and no significant efficacy was found in the subgroup analyses. In this retrospective study with propensity score analysis, FN resection did not improve survival outcomes in patients without preoperative facial palsy treated surgically for a primary parotid cancer abutting the FN. In line with recent guidelines, the results of this study suggest that FN preservation should be considered whenever possible in this specific group of patients.

Identifiants

DOI: 10.1016/j.ejso.2024.108746 PMID: 39424524
pubmed: 39424524
pii: S0748-7983(24)00803-5
doi: 10.1016/j.ejso.2024.108746
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108746

Investigateurs

C Ala-Eddine (C)
K Aubry (K)
E Babin (E)
C Bach (C)
C Badoual (C)
A C Baglin (AC)
B Barry (B)
V Bastit (V)
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Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have declared no conflict of interest.

Auteurs

Florian Chatelet (F)

Université Paris Cité, ENT - Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM UMR 1153 ECSTRRA team, F-75010, Paris, France. Electronic address: florian.chatelet@aphp.fr.

Sylvie Chevret (S)

Université Paris Cité, SBIM AP-HP Hôpital Saint Louis, INSERM UMR 1153 ECSTRRA Team, F-75010, Paris, France.

Nicolas Fakhry (N)

Department of Otolaryngology - Head and Neck Surgery, Universitary Hospital of la Conception, 147 Boulevard Baille, F-13005, Marseille, France.

Caroline Even (C)

Head and Neck Oncology Department, Gustave Roussy Cancer Campus, 114 Rue Edouard Vaillant, F-94807, Villejuif, France.

Olivier Malard (O)

ENT and Head and Neck Department, CHU Nantes, 1 place A. Ricordeau Hôtel Dieu, F-44093, Nantes cedex, INSERM U1229-RMeS, France.

Erwan de Monès (E)

University of Bordeaux, ENT and Head and Neck Department, CHU Bordeaux, F-33000, Bordeaux, France.

Nicolas Saroul (N)

ENT and Head and Neck Department, CHU Clermont-Ferrand, Clermont Ferrand University, F-63000, Clermont-Ferrand, France.

François Mouawad (F)

ENT and Head and Neck Department, Huriez Hospital, Lille University, CHU Lille, rue Michel Polonovski, F-59037, Lille cedex, France.

Marie de Boutray (M)

Department of ENT, Neck Surgery and Maxillofacial Surgery, Gui de Chauliac University Hospital, Montpellier University, Montpellier, France.

Olivier Mauvais (O)

ENT and Head and Neck Department, CHU Besancon, 3 boulevard Alexandre Fleming, F-25030, Besançon Cedex, France.

Sébastien Vergez (S)

Head and Neck Surgery Department, University Hospital of Toulouse-Larrey, 24 chemin de Pouvourville, F-31059, Toulouse, cedex9, France.

Diane Evrard (D)

Université Paris Cité, ENT and Head and Neck Surgery Department, AP-HP, Hôpital Bichat, France.

Christian Righini (C)

Head and Neck Surgery, University Hospital of Grenoble Alpes, UGA/UMR/CNRS 5309/Inserm 1209, groupe 5, Grenoble, France.

Philippe Schultz (P)

ENT and Head and Neck Department, Hautepierre Hospital, CHU Strasbourg, Avenue Molière, F-67098, Strasbourg cedex, France.

Robin Baudouin (R)

ENT and Head and Neck Department, Foch Hospital, 40 rue Worth, F-92150, Suresnes, France; Paris Saclay University, France.

Gilles Poissonnet (G)

Face and Neck University Institute, 31 Av. de Valombrose, F-06103, Nice, France; Antoine Lacassagne Center, 33 Av. de Valombrose, F-06189, Nice, France.

Sarah Atallah (S)

Sorbonne University, APHP, Department of ENT-Head and Neck Surgery, Tenon Hospital, 4 rue de la chine, F-75020, Paris, France; Doctoral School of Public Health, CESP, University of Paris Sud, 16 Avenue Paul Vaillant Couturier, F-94807, Villejuif, France.

Fabienne Haroun (F)

ENT and Head and Neck Department, Université Paris Cité, HEGP, AP-HP, 20-40, rue Leblanc, F-75015, Paris, France.

Sylvain Morinière (S)

ENT and Head and Neck Department, CHU Tours, 2, boulevard Tonnellé, F-37044, Tours, France; Université François-Rabelais, 10 boulevard Tonnellé, F-37000, Tours, France.

Camille Evrard (C)

Department of Medical Oncology, CHU, Université de Poitiers, Poitiers, France.

Pierre Philouze (P)

Department of Otolaryngology-Head Neck Surgery, Croix-Rousse Hospital, Hospices Civils de Lyon, Lyon, France; Claude Bernard University Lyon 1, France.

Agnès Paasche (A)

Department of Maxillofacial Surgery, CHU Amiens, CHIMERE team UR 7516 UPJV Amiens, France.

Maria Lesnik (M)

Department of ENT Surgery, Institute Curie, F-75005, Paris, France.

Yann Lelonge (Y)

ENT and Head and Neck Department, CHU Saint-Étienne, Avenue Albert Raimond, F-42270, Saint-Priest en Jarez, France.

Philippe Herman (P)

Université Paris Cité, ENT - Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM U1141, F-75010, Paris, France.

Benjamin Verillaud (B)

Université Paris Cité, ENT - Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM U1141, F-75010, Paris, France.

Classifications MeSH