Comparison of the quantitative contrast sensitivity function between early keratoconus and normal eyes.
Keratoconus
Quantitative contrast sensitivity
Visual acuity
Journal
BMC ophthalmology
ISSN: 1471-2415
Titre abrégé: BMC Ophthalmol
Pays: England
ID NLM: 100967802
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
19
02
2024
accepted:
23
09
2024
medline:
19
10
2024
pubmed:
19
10
2024
entrez:
18
10
2024
Statut:
epublish
Résumé
To compare the characteristics of the quantitative contrast sensitivity function (qCSF) in eyes with early keratoconus (Early-KC) and normal control (NC) eyes and investigate the associated factors. A cross-sectional study. This study included 43 eyes of 43 patients with Early-KC (including subclinical keratoconus [SKC] and forme fruste keratoconus [FFKC]) and 77 NC eyes of 77 participants with corrected distance visual acuity (CDVA) all ≥ 20/20. Contrast sensitivity (CS) was assessed using the qCSF tests. Subgroup analysis was performed according to keratoconus type(SKC and FFKC) and astigmatism(cylindrical refraction >-1.0D or ≤-1.0D). Sex ratio, spherical refraction, and spherical equivalent (SE) varied significantly between the two groups (all P < 0.01). The area under log CSF (AULCSF), CSF Acuity, and CS at low (1.0 and 1.5 cycles per degree [cpd]) and high (12.0 and 18.0 cpd) spatial frequencies decreased significantly in the Early-KC group than that in the NC group (all P < 0.05). The subgroup analysis revealed a similar decrease in the SKC group (all P < 0.05). AULCSF, CSF Acuity, and CS at high spatial frequencies of patients with cylindrical refraction ≤-1.0D in the Early-KC group decreased significantly (all P < 0.05) than those in the NC group. The index of vertical asymmetry and index of height decentration correlated negatively with CS at 1.5 cpd (r= -0.321 and -0.306; both P < 0.05). CS decreased significantly at low and high spatial frequencies in Early-KC, though with normal CDVA. The qCSF test can sensitively reflect visual performance in early keratoconus.
Identifiants
pubmed: 39425133
doi: 10.1186/s12886-024-03695-0
pii: 10.1186/s12886-024-03695-0
doi:
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
458Subventions
Organisme : Project of Shanghai Science and Technology
ID : 20410710100
Organisme : Clinical Research Plan of SHDC
ID : SHDC2020CR1043B
Organisme : Project of Shanghai Xuhui District Science and Technology
ID : XHLHGG202104
Organisme : National Natural Science Foundation of China
ID : 82271119
Organisme : Shanghai Rising-Star Program
ID : 23QA1401000
Organisme : Healthy Young Talents Project of Shanghai Municipal Health Commission
ID : 2022YQ015
Informations de copyright
© 2024. The Author(s).
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