Drug retention after intradiscal administration.

Animals Rats Intervertebral Disc Degeneration / drug therapy Drug Delivery Systems / methods Microspheres Intervertebral Disc / drug effects Polyesters / chemistry Male Peptides / chemistry Rats, Sprague-Dawley Hydrophobic and Hydrophilic Interactions
Drug retention intervertebral disk degeneration peptide polyester amide microsphere small molecule

Journal

Drug delivery
ISSN: 1521-0464
Titre abrégé: Drug Deliv
Pays: England
ID NLM: 9417471

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 20 10 2024
pubmed: 20 10 2024
entrez: 20 10 2024
Statut: ppublish

Résumé

Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release and retention of an inactive hydrophilic fluorine-19 labeled peptide ( Tissue degeneration alters molecule retention in tissues with a low fluid clearanceExtrapolating retention between different anatomical locations is not recommendedDrug delivery platforms should be customized to anatomical locationDrug delivery platforms should be customized to existing pathophysiology.

Autres résumés

Type: plain-language-summary (eng)
Tissue degeneration alters molecule retention in tissues with a low fluid clearanceExtrapolating retention between different anatomical locations is not recommendedDrug delivery platforms should be customized to anatomical locationDrug delivery platforms should be customized to existing pathophysiology.

Identifiants

DOI: 10.1080/10717544.2024.2415579 PMID: 39427239
pubmed: 39427239
doi: 10.1080/10717544.2024.2415579
doi:

Substances chimiques

Polyesters 0
Peptides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2415579

Auteurs

Imke Rudnik-Jansen (I)

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Department Anesthesiology and Pain Management, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands.
Department Translational Neuroscience, School of Mental Health and Neuroscience (MHeNs), University of Maastricht, Maastricht, The Netherlands.

Jie Du (J)

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

Nina Karssemakers-Degen (N)

DSM Biomedical, Geleen, The Netherlands.

Anna R Tellegen (AR)

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Parvesh Wadhwani (P)

Institute of Biological Interfaces (IBG2) and Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

Daniele Zuncheddu (D)

AO Research Institute Davos, Davos, Switzerland.

Björn P Meij (BP)

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Jens Thies (J)

DSM Biomedical, Geleen, The Netherlands.

Pieter Emans (P)

Department of Orthopaedics, Maastricht University Medical Center, Joint-Preserving Clinic Maastricht, The Netherlands.

Fetullah C Öner (FC)

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

George Mihov (G)

DSM Biomedical, Geleen, The Netherlands.

Joao Pedro Garcia (JP)

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

Anne S Ulrich (AS)

Institute of Biological Interfaces (IBG2) and Institute of Organic Chemistry (IOC), Karlsruhe Institute of Technology (KIT), Karlsruhe, Germany.

Sibylle Grad (S)

AO Research Institute Davos, Davos, Switzerland.

Marianna A Tryfonidou (MA)

Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Hugo van Ingen (HV)

NMR Group, Bijvoet Centre for Biomolecular Research, Utrecht University, Utrecht, The Netherlands.

Laura B Creemers (LB)

Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Drug retention after intradiscal administration.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Drug retention after intradiscal administration.
questionsmedicales.fr › Maladies ostéomusculaires › Maladies osseuses › Maladies du rachis › Dégénérescence de disque intervertébral › Drug retention after intradiscal administration.
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Drug retention after intradiscal administration.
questionsmedicales.fr › Équipement et fournitures › Microsphères › Drug retention after intradiscal administration.
questionsmedicales.fr › Tissus › Tissu conjonctif › Cartilage › Fibrocartilage › Disque intervertébral › Drug retention after intradiscal administration.
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Drug retention after intradiscal administration.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Drug retention after intradiscal administration.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Drug retention after intradiscal administration.
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Drug retention after intradiscal administration.