Design of experiments optimization of N,N,N-trimethyl chitosan synthesis using N,N-diisopropylethylamine base.

This study presents a novel synthesis method of N,N,N-trimethyl chitosan (TMC) by using a non-nucleophilic base and optimizing the solvent system for enhanced scalability, while addressing critical factors such as viscosity management and stirring efficiency. The study objectives also included achieving high N,N,N-trimethylation without O-methylation while minimizing reagent use. Eight bases, three solvent systems, and varying levels of dilution were explored to mitigate viscosity challenges and gas evolution.

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Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Vivien Nagy reports financial support was provided by The Icelandic Centre for Research. Helene Liette Lauzon reports a relationship with Primex ehf. that includes: employment. Mar Masson has patent #Chitosan derivatives and methods for preparing the same issued to Primex ehf. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.