Acute transcutaneous auricular vagus nerve stimulation modulates presynaptic SV2A density in healthy rat brain: An in vivo microPET study.
PET
[11C]UCB‐J, [18F]FDG
glucose metabolism
synaptic vesicle glycoprotein 2A (SV2A)
transcutaneous auricular vagus nerve stimulation
Journal
Psychophysiology
ISSN: 1469-8986
Titre abrégé: Psychophysiology
Pays: United States
ID NLM: 0142657
Informations de publication
Date de publication:
20 Oct 2024
20 Oct 2024
Historique:
revised:
01
10
2024
received:
31
03
2024
accepted:
04
10
2024
medline:
21
10
2024
pubmed:
21
10
2024
entrez:
21
10
2024
Statut:
aheadofprint
Résumé
Vagus nerve stimulation (VNS) is the subject of exploration as an adjunct treatment for neurological disorders such as epilepsy, chronic migraine, pain, and depression. A non-invasive form of VNS is transcutaneous auricular VNS (taVNS). Combining animal models and positron emission tomography (PET) may lead to a better understanding of the elusive mechanisms of taVNS. We evaluated the acute effect of electrical stimulation of the left vagus nerve via the ear on brain synaptic vesicle glycoprotein 2A (SV2A) as a measure of presynaptic density and glucose metabolism in naïve rats. Female Sprague-Dawley rats were imaged with [
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14709Subventions
Organisme : Fabrikant Vilhelm Pedersen og Hustrus Legat
Organisme : Fonden til Lægevidenskabens Fremme
Organisme : Graduate School of Health, Aarhus University
Organisme : Danmarks Frie Forskningsfond
Informations de copyright
© 2024 The Author(s). Psychophysiology published by Wiley Periodicals LLC on behalf of Society for Psychophysiological Research.
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